Stefan Ruhl

Stefan Ruhl

Stefan Ruhl

Professor, DDS, PhD

Department of Oral Biology

School of Dental Medicine

Specialty/Research Focus

Operative Dentistry; Oral Biology; Pediatric Dentistry; Periodontics

Contact Information
Department of Oral Biology
University at Buffalo
Foster Hall, Room 213A
Buffalo, NY 14214-3092
Phone: (716) 829-6073
Fax: (716) 829-3942
shruhl@buffalo.edu
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Overview Research Publications Activities Latest News

Professional Summary:

My laboratory investigates the molecular mechanisms of initial bacterial attachment to teeth, tissue, or biomaterial surfaces in the mouth. We try to unravel the molecular mechanisms of how glycoproteins in saliva or on host cells are recognized by glycan-binding microbial adhesins. It is our long-term goal to better understand the modulating role of saliva in supporting colonization of the human oral cavity by a benign commensal microbiota, and in host defense against pathogenic microorganisms. More recently, our research involves the investigation of evolutionary mechanisms that have shaped host-microbial interactions in the human mouth.

A more detailed description of our current research activities can be found on the following website: www.ruhl-lab.org

Education and Training:
  • Professor (C3), Operative Dentistry and Periodontology, Universität Regensburg (2004)
  • Privatdozent, venia legendi, Operative Dentistry and Periodontology, Universität Regensburg, (venia legendi) (2000)
  • PhD, Dr. med. dent., Georg-August-Universität Göttingen, Magna Cum Laude (1988)
  • DDS, Dentistry, Georg-August-Universität Göttingen (1984)

Employment:
  • Associate Chair, Oral Biology, University at Buffalo (2019-present)
  • Adjunct Professor, Microbiology and Immunology, University at Buffalo (2016-present)
  • Professor, Oral Biology, University at Buffalo (2015-present)
  • Acting Chair, Oral Biology, University at Buffalo (2019–2020)
  • Adjunct Associate Professor, Microbiology and Immunology, University at Buffalo (2011–2016)
  • Associate Professor, Oral Biology, University at Buffalo (2011–2015)
  • Assistant Professor, Oral Biology, University at Buffalo (2007–2011)
  • Adjunct Assistant Professor, Microbiology and Immunology, University at Buffalo (2008–2010)
  • Professor (C3) Germany, Department of Operative Dentistry and Periodontology, University of Regensburg, Medical/Dental School, Germany (2004–2007)
  • Associate Professor (C2) Germany, Department of Operative Dentistry and Periodontology, Universität Regensburg, Germany (2000–2004)
  • Assistant Professor (C1) Germany, Operative Dentistry and Periodontology, University of Regensburg, Medical/Dental School, Germany (1995–2000)
  • Visiting Associate, Laboratory of Microbial Ecology, National Institute of Dental Research, NIH (1991–1994)
  • Visiting Associate, Division of Cytokine Biology, Center for Biologics Evaluation and Research, FDA (1989–1991)
  • Guest Researcher, Laboratory of Immunology, National Institute of Dental Research, NIH (1988–1989)
  • Dentist, Private practice in Germany, Germany (1986–1988)
  • Doctoral Candidate, Institute of Medical Microbiology and Immunology, Georg-August-University, Göttingen, Germany, Medical School, Germany (1985–1986)
  • Military Service, Hochgebirgszug, Gebirgsjäger, Bad Reichenhall, German Military, Germany (1978–1979)
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Awards and Honors:
  • AAAS Fellow, American Association for the Advancement of Science (2020)
  • UB Exceptional Scholar Award for Sustained Achievement (2020)
  • IADR Distinguished Scientist Award in Salivary Research (2020)
  • Salivary Researcher of the Year Award (2015)
  • Omicron Kappa Upsilon, National Dental Honor Society (2014)
  • UB-SDM Society for the Advancement of Dental Research Award (2011)
  • WALKHOFF Award (2007)
  • WRIGLEY Award (2007)
  • Dentsply Award (2005)
  • Dentsply Award (1999)
  • CORSODYL Research Award (1998)
  • Poster Award, 17th International Lectin Conference (1997)
  • Poster Award, German Society for Operative Dentistry (1996)
  • Postdoctoral Fellowship, German Research Foundation (DFG) (1988)
  • Postgraduate Fellowship (GradFöG), Universität Göttingen (1985)

Research Expertise:
  • Bacterial adhesion to biomaterials
  • Evolution of saliva and salivary proteins
  • Glycobiology of microbial adhesion
  • Saliva proteomics

Grants and Sponsored Research:
  • July 2018–June 2023
    Microbial Recognition of Sialic Acid Diversity in the Oral Cavity
    NIDCR
    Role: Principal Investigator
  • July 2018–June 2020
    Glycan binding of oral streptococci and its impact on phagocyte activation
    NIDCR
    Role: Contributor
  • July 2017–June 2020
    Harnessing the Oral Microbiome to Create Novel Glycan-Binding Probes
    NCI
    Role: Principal Investigator
  • February 2019–January 2020
    2019 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar
    NIDCR
    Role: Co-Principal Investigator
  • July 2016–June 2018
    Mechanisms of Streptococcus gordonii survival within phagocytes.
    NIH/NIDCR
    Role: Contributor
    $239,250
  • August 2015–July 2017
    Mining the oral Microbiome for novel glycan-binding molecules
    NIDCR
    Role: Principal Investigator
  • July 2013–July 2015
    Supplement to: Microbial recognition of sialic acid diversity in the salivary proteome
    NIH/NIDCR
    Role: Principal Investigator
  • July 2010–June 2015
    Microbial recognition of sialic acid diversity in the salivary proteome
    NIH
    Role: Principal Investigator
  • April 2014–April 2015
    The functional & biomedical implications of the unusual genetic variation in the salivary MUC7 protein
    UB-IMPACT
    Role: Co-Principal Investigator
  • July 2011–June 2012
    Saliva Spectral Analysis for New Fertility Diagnosis
    NYSTAR / UB-CAT
    Role: Principal Investigator
  • July 2007–July 2009
    Charged dendrimers as an antibacterial coating for biomaterial surfaces
    German Research Foundation (DFG)
    Role: Co-Principal Investigator
  • February 2006–July 2007
    Identification of receptors in human saliva for the adhesins of Actinomyces viscosus T14V
    German Society for Dental and Cranio-mandibular Science (DGZMK)
    Role: Principal Investigator
  • January 2002–December 2005
    Interactions of Helicobacter pylori with salivary glycoproteins
    German Research Foundation (DFG)
    Role: Principal Investigator
  • January 1999–December 2000
    Salivary proteins and glycoproteins in children with nursing bottle caries
    German Research Foundation (DFG)
    Role: Principal Investigator
  • June 1998–June 1998
    Travel grant
    German Society for Dental and Cranio-mandibular Society (DGZMK)
    Role: Principal Investigator
  • January 1997–December 1997
    ReForM-A
    University of Regensburg
    Role: Principal Investigator
  • March 1996–March 1996
    Travel grant
    German Research Foundation (DFG)
    Role: Principal Investigator
  • July 1988–June 1990
    Immunologic, microbiologic aspects of the caries process / periodontal diseases
    German Research Foundation (DFG)
    Role: Principal Investigator
  • July 1985–April 1986
    Characterization of human dendritic cells and their functions
    State of Niedersachsen
    Role: Principal Investigator
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Journal Articles:

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Books and Book Chapters:

  • Scannapieco FA, Ruhl S. The Oral Environment. 2019.
  • Ruhl S, Moder D, Schmalz, G. Pathophysiologie der entzüdlichen Parodontalerkrankungen. Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 2: Spezielle Pathophysiologie. 2007; 2(2).
  • Ruhl S, Begley CG, Bickel M, Pluznik DH. Interleukin-2 receptors on monocytes and their relation to the process of monocytic cell differentiation. Experimental Hematology Today-1989. 1989.

Abstracts:

  • Thamadilok S, Khedri Z, Deng L, Gill A, Lettrichova I, Diaz S, Gill S, Varki A, Ruhl S. Human oral streptococci that bind to a non-human sialic acid. J. Dent. Res.. 2017; 96(A).
  • Xu D, Pavlidis P, Flanagan C, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O. Evolution of MUC7: Insights into human salivary adaptation.. Am. J. Phys. Anthropol.. 2016; 159.
  • Thamadilok S, Roche-Håkansson H, Hakånsson AP, Ruhl S. Glycan-mediated binding of Streptococcus pneumoniae to salivary mucin MUC7.. J. Dent. Res.. 2016; 95(A).
  • Ruhl S. Salivary control of oral microflora. J. Dent. Res.. 2015; 94(B).
  • Di Pirro C, Ruhl S. Activation of host neutrophils through sialic acid binding by Streptococcus gordonii. J Dent Res. 2015; 94(A).
  • Lettrichova I, Anderson R, Goldman D, Butler WR, Ruhl S. Salivary sialic acid: a potential marker of ovulation?. J Dent Res. 2015; 94(A).
  • Thamadilok S, Choi K-S, Ruhl L, Reddy MS, Kazim AL, Ruhl S. Sialic acid-binding oral streptococci isolated from humans and great apes. J Dent Res. 2015; 94(A).
  • Wu S, White G, Müller R, Ruhl S. Chemical surface modifications influence salivary protein adsorption to biomaterials. J Dent Res. 2015; 94(A).
  • Heo SM, Choi K-S, Kazim AL, Haase EM, Reddy MS, Scannapieco FA, Ruhl S. Host Defense Proteins Derived from Human Saliva Bind to Staphylococcus aureus.. Adv Dent Res. 2014; 26.
  • Di Pirro C, Ruhl S. Role of sialic acid binding in activation of host neutrophils by Streptococcus gordonii. Adv Dent Res. 2014; 26.
  • Lettrichova I, Anderson R, Goldman D, Butler WR, Ruhl S. Salivary parameters during the estrous cycle in cows. Adv Dent Res. 2014; 26.
  • Thamadilok S, Choi K-S, Ruhl L, Reddy MS, Kazim AL, Ruhl S. Comparing human, chimpanzee, and gorilla salivas: a proteomic perspective. Adv Dent Res. 2014; 26.
  • Lettrichova I, Anderson R, Nguyen P, Goldman D, Butler WR, Ruhl S. Salivary parameters during the estrous cycle in domestic cows. J Dent Res. 2014; 93.
  • Thamadilok S, Anderson R, Roche-Håkansson H, Hakansson AP, Ruhl S. Binding of salivary sialoglycoproteins by streptococci carrying serine-rich repeat adhesins. J Dent Res. 2014; 93.
  • Heit SH, Thamadilok S, Deng L, Varki A, Ruhl S. Sialoglycan binding specificities of oral streptococci. J Dent Res. 2014; 93.
  • Thamadilok S, Choi K-S, Ruhl L, Reddy MS, Kazim AL, Ruhl S. Human lineage-specific traits in the salivary proteome. J Dent Res. 2014; 93.
  • Thamadilok S, Choi K-S, Ruhl L, Reddy MS, Kazim AL, Ruhl S. Comparison of the human, chimpanzee, and gorilla salivary proteomes. J Dent Res. 2013; 92.
  • Deng L, Bensing BA, Thamadilok S, Yu H, Chen X, Ruhl S, Sullam PM, Varki A. Exploring the sialoglycan binding properties of a family of bacterial adhesins containing a novel Siglec-like domain that contributes to bacterial virulence. Glycobiology. 2013; 23.
  • Thamadilok S, Roche-Håkansson H, Schwartz R, Hakansson AP, Ruhl S. Binding of Streptococcus pneumoniae to salivary glycoproteins. J Dent Res. 2012; 91.
  • Thamadilok S, Choi K-S, Ruhl L, Reddy MS, Kazim AL, Ruhl S. Comparative proteomic analysis of saliva from hominids. J Dent Res. 2011; 90(A).
  • White GD, Katzur V, Reddy MS, Muller R, Ruhl S. Human salivary protein adsorption onto chemically modified silica beads. J Dent Res. 2011; 90(A).
  • Müller R, Eidt A, Hiller KA, Katzur V, Eichler M, Rupp F, Geis-Gerstorfer J, Ruhl S, Schmalz G, Schweikl H. Bakterienadhäsion auf Modelloberflächen beschichtet mit Polyamidoamindendrimeren unterschiedlicher Ladung. Biomaterialien. 2011; 79.
  • Müller R, Katzur V, Eichler M, Schweikl H, Hiller KA, Schmalz G, Ruhl S, Scheideler L, Geis-Gerstorfer J, Rupp F. Eignen sich geladene Dendrimere als antiadhäsive und/oder antimikrobielle Beschichtung von Biomaterialoberflächen?. Biomaterialien. 2011; 12.
  • Eidt A, Lee DH, Heo SM, Haase EM, Reischl U, Cisar JO, Scannapieco FA, Ruhl S. Coadhesion Partners for Helicobacter pylori Among Oral Biofilm Microbiota. J Dent Res. 2010; 89.
  • Ruhl S, Eidt A, Reischl U, Cisar JO. Coadhesion Partners for Actinomyces naeslundii from Dental Biofilm Microbiota. J Dent Res. 2010; 89.
  • Ruhl S. Helicobacter pylori in the Oral Cavity and the Role of Saliva. J Dent Res. 2009; 88.
  • Palmer R, Ruhl S, Kolenbrander PE, Cisar JO. Veillonellae selectively recognize streptococcal Galb1-3GalNAc-containing receptor polysaccharides. J. Dent. Res.. 2007.
  • Muller R, Hiller KA, Schmalz G, Ruhl S. Chemiluminescence-based method for quantification of adsorbed proteins on material surfaces. J. Dent. Res.. 2007.
  • Walz A, Stuehler K, Wattenberg A, Hawranke E, Meyer HE, Schmalz G, Blueggel M, Ruhl S. Consistency and variance in human saliva 2-D proteome. J Dent Res. 2006; 85(A).
  • Ruhl S, Ganga-Raju P, Langenfelder S, Horl D, Lehn N, Schmalz G, Hiller K-A, Durchschlag H. Sterlization of human saliva by irradiation or filtration. J Dent Res. 2006; 85(A).
  • Hiller K-A, Dorner S, Kaes C, Schmalz G, Ruhl S. Quantification of adsorbed salivary proteins on dental biomaterial surfaces. J Dent Res. 2006; 85(A).
  • Muller R, Ruhl S, Hiller K-A, Schmalz G, Schweikl H. Fibronectin enhances cell adhesion on a hydrophobic fluorocarbon surface. Biomaterialien. 2006.
  • Walz A, Wattenberg A, Schmalz G, Blueggel M, Ruhl S. Proline-rich proteins as major part of the human saliva proteome. J Dent Res. 2005; 84(A).
  • Ruhl S, Eidt A, Cisar JO. A bacteria overlay method for detecting specific interbacterial adhesion. J Dent Res. 2005; 84(A).
  • Muller R, Ruhl S, Englert C, Nerlich M, Groger G, Hiller K-A, Schmalz G, Schweikl H. Different adhesion behavior of bacteria and eukaryotic cells on model surfaces. Biomaterialien. 2005; 6(3).
  • Ruhl S. Adhasion von Bakterien auf Oberflachen zahnarztlicher Werkstoffe. Dtsch Zahnarztl. 2005; Z(A).
  • Walz A, Ruhl S. Rezeptoren fur H. pylori im Speichel. Dtsch Zahnarztl. 2005; Z(D).
  • Engel K, Aspholm M, Walz A, Ruhl S, Faller G, Haas R, Boren T, Odenbreit S. Interrelations between AlpAB-,BabA- and SabA-dependent adherence activities of Helicobacter pylori. Biospektrum. 2005; GIV.
  • Muller R, Thalmaier U, Schmalz G, Ruhl S. Bacterial adhesion to surfaces of defined polarity in relation to previous protein adsorption. Eur Cell Mater. 2004; 7(1).
  • Burgers R, Schneider-Brachert W, Reischl U, Schmalz G, Hiller K-A, Ruhl S. Helicobacter pylori in human oral cavity and stomach. J Dent Res. 2004; 83(B).
  • Walz A, Odenbreit S, Schmalz G, Ruhl S. Characterisation of binding specificities of Helicobacter pylori adhesins by glycoconjugate arrays. Glycoconj J. 2004; 21.
  • Ruhl S, Hamberger S, Betz R, Sukkar T, Schmalz G, Seymour RA, Hiller K-A, Thomason JM. Cytokines and growth factors in saliva of patients with cyclosporin-induced gingival overgrowth. J Dent Res. 2003; 82(B).
  • Ruhl S, Schmalz G, Seymour RA, Betz R, Hamberger S, Hiller K-A, Thomason JM. Salivary proteins and glycoproteins in patients with cyclosporin-induced gingival overgrowth. J Dent Res. 2003; 82(C).
  • Ruhl S, Rayment SA, Schmalz G, Troxler RF. Expression of salivary mucins during the first year of infancy. J Dent Res. 2002; 81(A).
  • Ruhl S, Heep M, Schneider-Brachert W, Schmalz G. Adhasion von Helicobacter pylori an Speichelproteinen. Dtsch Zahnarztl Z. 2002; (D).
  • Ruhl S, Schmalz G, Hamberger S, Thomason JM, Hiller K-A, Seymour RA. Salivary cytokines in patients with cyclosporin-induced gingival overgrowth. J Dent Res. 2000; 79.
  • Ruhl S, Betz R, Hamberger S, Schmalz G. Influence of storage and centrifugation on the electrophoretic pattern of salivary proteins. J Dent Res. 2000; 79.
  • Heep M, Ruhl S, Wehrl W, Senzenberger S, Lehn N, Schmalz G. Adhesion of different strains of H. pylori to salivary glycoproteins. Gut 47. 2000; 47(A).
  • Ruhl S, Schmalz G. Salivary proteins and glycoproteins during the first year of infancy. J Dent Res. 1999; 78.
  • Ruhl S, Schmalz G. Analysis of donor-specific salivary glycoprotein profiles by lectin blotting. J Dent Res. 1998; 77.
  • Ruhl S, Sandberg AL, Cisar JO. Lectin-mediated binding of streptococci and actinomyces to granulocyte glycoprotein receptors. J Dent Res. 1997; 76.
  • Ruhl S, Sandberg AL, Cisar JO. Lectin-mediated binding of streptococci and actinomyces to leukosialin and leukocyte common antigen on granulocytes. Eur J Cell Biol. 1997; 74(46).
  • Ruhl S, Sandberg AL, Cisar JO. Salivary proteins and glycoproteins recognized by actinomyces and streptococcal adhesins. J Dent Res. 1996; 75.
  • Ruhl S, Cisar JO, Cole M, Sandberg AL. Recognition of IgA by oral bacterial lectins. Adv Dent Res. 1996; 11.
  • Ruhl S, Sandberg AL, Cole MF, Cisar JO. Surface-associated IgA1 as an attachment receptor for oral bacterial lectins. Immunobiol. 1996; 196.
  • Takahashi Y, Cisar JO, Ruhl S, Sandberg AL. A Streptococcus gordonii DL1 antigen with sialic acid lectin reactivity. J Dent Res. 1995; 74.
  • Ruhl S, Sandberg AL, Cisar JO. Leukosialin (CD43), a granulocyte receptor for streptococcal and actinomyces lectins. J Dent Res. 1994; 73.
  • Ruhl S, Sandberg AL, Cisar JO. Binding of actinomyces and streptococci to HL-60 cells during differentiation towards granulocytes. J Dent Res. 1993; 72.
  • Ruhl S, Cohen B, Pluznik DH. Transcription is a major mechanism regulating the synergistic action of IL-6 and IL-1 on interleukin-2 receptor expression during myeloid differentiation. J Cell Biochem. 1991; 15(F).
  • Ruhl S, Feldman GM, Finbloom DS, Pluznik DH. Regulation of interleukin-4 receptor expression on primitive and mature myeloid cells by the hematopoietic growth factor interleukin-6. Exp Hematol. 1991; 19.
  • Ruhl S, Bickel M, Pluznik DH. Differential regulation of leukemia inhibitory factor-and interleukin-6-induced expression of surface markers in differentiating myeloid cells. J Cell Biochem Suppl. 1990; 14(B).
  • Ruhl S, Pluznik DH. Early and late events during myeloid differentiation can be distinguished by use of interleukin-6 and interferon-gamma. Exp Hematol. 1990; 18.
  • Ruhl S, Schwabe M, Pluznik DH. Interleukin-1 augments interleukin-2 receptors on differentiating macrophages. Lymphokine Res. 1990; 9.
  • Feldman GM, Ruhl S, Pluznik DH, Finbloom DS, Bickel M. Mechanism of interleukin-4 receptor regulation during macrophage activation by IL-6. Lymphokine Res. 1990; 9.
  • Ruhl S, Begley CG, Bickel M, Pluznik DH. Interleukin-2 receptor (IL2R) on murine myeloid leukemia cells is induced by leukemia inhibitory factor (LIF) and interleukin-6 (IL6) and represents an early marker of myeloid differentiation. Exp Hematol. 1989; 17.
  • Dieffenbach CW, Dveksler G, Ruhl S, Bickel M, Pluznik. Interferon and 2‘5‘A synthetase mRNA levels in murine monocytic leukemia cells (M1) after induction of differentiation. J Interferon Res. 1989; 9.
  • Ruhl S, Begley CG, Bickel M, Pluznik DH. Transient expression of interleukin-2 receptors during early stages of interleukin-6 and leukemia inhibitory factor induced murine myeloid cell differentiation. Cytokine. 1989; 1.
  • Peters JH, Ruhl S, Friedrichs D, Saur T. Veiled accessory (dendritic cells) deduced from monocytes. Immunobiol. 1987; 175.
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Professional Memberships:
  • International Society for Evolution, Medicine & Public Health (ISEMPH) (2015–present)
  • American Association for the Advancement of Science (AAAS) (2014–present)
  • American Society for Microbiology (ASM) (2013–present)
  • Central European Division of the IADR (CED) (2013–present)
  • Society for Glycobiology (2008–present)
  • Consortium for Functional Glycomics (2008–present)
  • American Association for Dental Research (AADR) (2008–present)
  • German Society for Biochemistry and Molecular Biology (GBM); • Studygroup Glycobiology (1997–present)
  • International Association of Dental Research (IADR); , Salivary Research Group, Microbiology and Immunology Interest Group (1995–present)
  • German Society of Dental, Oral, and Craniomandibular Sciences (DGZMK); • German Society for Operative Dentistry (DGZ) • German Society for Pediatric Dentistry and Prophylaxis (DGK) • Studygroup for Basic Science (AfG) (1995–present)
  • German Society for Immunology (1995–present)
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Presentations:
  • "Etiology and Risk Assessment for Dental Caries" Best Practices in UB School of Dental Medicine Clinics, School of Dental Medicine (2017)
  • "Salivary Glycoproteins as a First Line Oral Host Defense" American Association of Immunologists Annual Meeting (2017)
  • "Diagnostic Potential of Bacterial Glycan Recognition at the Salivary Proteome - Oral Microbiome Interface" IADR/AADR/CADR General Session (2017)
  • "Sweet Spots at the Salivary Proteome - Oral Microbiome Interface" Invited Seminar Lecture, The Ohio State University, The Research Institute at Nationwide Children‘s Hospital (2016)
  • "Diagnostic Potential of Bacterial Glycan Recognition in Saliva" Invited Seminar Lecture, University of Rochester, Center for Oral Biology (2016)
  • "Human Lineage-Specific Footprints in the Salivary Proteome" Invited Seminar Lecture, The Forsyth Institute, The Forsyth Institute (2015)
  • "Sweet Spots at the Salivary Proteome - Oral Microbiome Interface" Invited Seminar Lecture, Boston University, Henry M. Goldman School of Dental Medicine (2015)
  • "Salivary Control of Oral Microflora" 47th Meeting of the Continental European Division of the IADR (CED-IADR) (2015)
  • "Diagnostic Potential of Bacterial Glycan Recognition in Saliva" International Symposium on Oral-Systemic Health "The Oral-Systemic Connection", West China School of Stomatology (2015)
  • "The Salivary Proteome – Oral Microbiome Interface" Göttingen Spirit Summer School, University of Göttingen (2015)
  • "A Slippery Path to a Career in Oral Biology" UB BIO-STEM / CLIMB-UP Scientific Discovery Series, University at Buffalo (2015)
  • "Mining the Oral Microbiome for Novel Glycan-Binding Molecules" NIH Common Fund Glycoscience Kick-off Meeting, NIH (2015)
  • "Activation of host neutrophils through sialic acid binding by Streptococcus gordonii" IADR General Session & Exhibition, IADR (2015)
  • "Human lineage-specific traits in the salivary proteome" Inaugural Meeting of the International Society for Evolution, Medicine & Public Health, International Society for Evolution, Medicine & Public Health (2015)
  • "Salivary Control of Oral Microflora" IADR General Session, IADR, Unilever Oral Care Sponsored Symposium "Saliva – Natural Defence for the Oral Cavity" (2015)
  • "Human Lineage-Specific Traits in the Salivary Proteome" Gordon Research Conference "Salivary Glands and Exocrine Biology, Gordon Research Conferences (2015)
  • "Custom-Designed Biomaterial Surface Coatings to Minimize Bacterial Colonization" Invited Seminar Lecture, Ivoclar Vivadent (2014)
  • "The Magical Properties of Spit" Biosciences Lecture (UB iSEED Recruitment), SUNY Geneseo (2014)
  • "A Slippery Path to a Career in Oral Biology" UB BIO-STEM / CLIMB-UP Scientific Discovery Series (2014)
  • "Human Lineage Specific Traits in the Salivary Proteome" IADR General Session & Exhibition, IADR (2014)
  • "The Diagnostic Potential of Bacterial Glycan Recognition in Saliva" 2013 SPIE DSS (Defense + Security, Sensing + Technology) Meeting (2014)
  • "Keynote: Studies on the Salivary Proteome - Oral Microbiome Interface" 43rd Annual Meeting & Exhibition of the AADR, AADR, Salivary Research Group (2014)
  • "The Salivary Proteome - Oral Microbiome Interface" Invited Seminar Lecture, University of Minnesota, School of Dentistry (2013)
  • "How I Became a Research Scientist" UB BioSTEM Lecture Series - CLIMB UP (2013)
  • "The Salivary Proteome - Oral Microbiome Interface" 50th Anniversary, UB Oral Biology Graduate Program (2013)
  • "The Importance of Saliva for a Healthy Mouth" UB Discovery Seminar - Oral Biology, University at Buffalo (2013)
  • "How does the Salivary Proteome Modulate Bacterial Adhesion?" Bagel Talk, University of Rochester, Center for Oral Biology, University of Rochester, URMC - Center for Oral Biology (2012)
  • "The Importance of Saliva for a Healthy Mouth - from a Glycobiologist's Perspective" SACNAS National Conference, SACNAS (2012)
  • "New Aspects in Cariology" UB SDM Back-to-School Conference, Pediatric Dentistry (2012)
  • "Binding between Human Salivary Components and Staphylococcus aureus" 41st Annual Meeting of the AADR, AADR (2012)
  • "Control of Oral Biofilm Formation on Biomaterials" UB Department of Chemistry (2012)
  • "Control of Oral Biofilm Formation on Biomaterials" UB Integrated Nanoscience Workshop (2012)
  • "How Saliva Mediates Bacterial Adhesion" The New Jersey Dental School (2011)
  • "The Importance of Saliva for the Dentist" UB-SDM Continuing Education (2011)
  • "It's in the Spit:: The Diagnostic Potential of Saliva" Buffalo Niagara Dental Meeting (2009)
  • "The Diagnostic Potential of Saliva" Continuing Dental Education, UB School of Dental Medicine (2008)
  • "A proteomics-based search for bacterial recognition sites in human saliva" Invited lecture, Department of Microbiology and Immunology, University at Buffalo, Department of Microbiology and Immunology (2008)
  • "A proteomics-based search for bacterial recognition sites in human saliva" Rochester Oral Biology Research Conference (2008)
  • "Bakterielle Erkennungsstrukturen im menschlichen Speichelproteom" Invited lecture, Medical Faculty, University of Gottingen, Germany, University of Gottingen (2007)
  • "Das menschliche Speichelproteom als Grundlage fur zukunftige Diagnostik" Deutscher Zahnarztetag 2007 (2007)
  • "Kinderzahnheilkunde und Alterszahnmedizin - Ein Gegensatz" Invited lecture, Medical Faculty, University of Gottingen, Germany, University of Gottingen, Medical Faculty (2007)
  • "Sticky spots in spit - a proteomics-based search for bacterial recognition sites in human saliva" Invited Lecture, Umea University, Sweden, Umea University, Department of Medical Biochemistry and Biophysics (2006)
  • "Adsorption of proteins and attachment of bacteria to biomaterial surfaces" International Symposium Material - Tissue Interactions (2006)
  • "The importance of saliva" Visit of the Academia Conservativa Italiana, University of Regensburg (2006)
  • "Spot Spitting and Spit Spotting: A Proteomics-Based Search for Functional Aspects in Saliva" Invited lecture, University of Buffalo, Department of Oral Biology (2006)
  • "Wissenswertes fur den Zahnarzt uber Speichel" Workshop: Speichel - "ein ganz besonderer Saft", Jahrestagung der Deutschen Gesellschaft fur Zahnerhaltung (2006)
  • "Adsorption von Proteinen und Adhasion von Bakterien auf Modelloberflachen und klinischen Werkstoffen" Medizinische Fakultat, Universitat Regensburg (2005)
  • "Adhasion von Bakterien auf Oberflachen zahnarztlicher Werkstoffe" Symposium der Arbeitsgemeinschaft fur Grundlagenforschung in der DGZMK (2005)
  • "Bedeutung des Speichels fur ein gesundes Mundmillieu" Klinischer Arbeitskreis im Qualitatszirkel des ZBV Oberpfalz (2005)
  • "Bestandteile des menschlichen Speichels und ihre Bedeutung" Institut fur Physikalische und Theroetische Chemie, Universitat Regensburg (2005)
  • "Speichel-'ein ganz besonderer Saft" Medizinische Fakultat, Universitat Leipzig (2005)
  • "Der Speichel als diagnostische Flussigkeit" Medizinische Facultat, Universitat Regensburg (2003)
  • "Speichel als diagnostische Flussigkeit" 2.Regionalkonferenz des Vereins zur Forderung der wissenschaftlichen Zahnheilkunde in Bayern, Kloster Seeon (2003)
  • "Adhasin-vermittelte Interaktionen oraler Midroorganismen mit Strukturen der Mundhohle" Institut fur Medizinische Mikrobiologie, Friedrich-Schiller-Universitat Jena (2003)
  • "Grundlagen und Stategien zahnarztlicher Prophylaxe" Klinischer Arbeitskreis im Qualitatszirkel des ZBV Oberpfalz (2003)
  • "Prophylaxe, mehr als nur Einfarben. Individualprophylaxe-Theorie und Praxis" 43. Bayerischer Zahnarztetag (2002)
  • "Moderne Prophlyaxe: Moglichkeiten, Chancen, Grenzen. Bleichung von Zahnen. Kinderzahnheilkunde:Endodontologie" Zahnarztlicher Fortbildungskreis, Rottal-Inn e.V. (2002)
  • "Adhasin-vermittelte Interaktionen von oralen Bakterien mit Strukturen der Mundhohle" Mikrobiologisch-Immunologisches Kolloquium, Univeritat Ulm, Abteilung fur Immunlogie (2002)
  • "Der diagnostische Stellenwert des Speichels fur die Kinderzahnheilkunde" Medizinische Fakultat, Christian-Albrechts-Universitat zu Kiel (2002)
  • "Immunologie der Mundhohle" Vorlesung Immunologie fur Zahnmediziner, Universitat Ulm, Abteilung fur Immunologie (2002)
  • "Proteine und Glykoproteine im Speichel: Funktionen und mogliche klinische Bedeutung" Zahn-, Mund- und Kieferklinik, Ludwig-Maximilians-Universitat Munchen (2001)
  • "Der Speichel als eine diagnostische Flussigkeit" Zentrum fur Zahn-, Mund- und Kieferheilkunde, Rheinische Friedrich-Wilhelms-Universitat Bonn (2001)
  • "Bleichung von Zahnen: Moglichkeiten und Grenzen" Klinischer Arbeitskreis im Qualitatszirkel des ZBV Oberpfalz (2001)
  • "Moderne Prophylaxe: Moglichkeiten, Chancen, Grenzen" 15. Oberpfalzer Zahnarztetag (2001)
  • "Adhasin-vermittelte Interaktionen oraler Mikroorganismen mit Strukturen der Mundhohle" Zentrum fur Biomaterialien an der Universitat Regensburg (2001)
  • "Adhasin-vermittelte Interaktionen von oralen Bakterien mit Strukturen der Mundhohle" Medizinische Fakultat, Rheinisch-Westfalische Technische Hochschule (2001)
  • "Salivary Proteins and Glycoproteins: Interactions with the Oral Microbial Flora and Possible Clinical Relevance" Oral Infection and Community Branch, National Institute of Dental and Craniofacial Research, NIH (2000)
  • "Kinderbehandlung: Milchzahnendodontie" Klinischer Arbeitskreis im Qualitatszirkel des ZBV Oberpfalz (1998)
  • "Proteine und Glykoproteine im Speichel: Funktion und klinische Relevanz" 39. Bayerischer Zahnarztetag 1998 (1998)
  • "Role of Sialic Acids in the Adhesion of Oral Bacteria" Sialinsaure-Workshop, Biochemisches Institute, Christian-Albrechts-Universitat zu Kiel, Gesellschaft zur Erforschung der Sialinsauren e.V. (1997)
  • "Salivary and Cell Surface Glycoprotein Receptors for Oral Bacterial Lectins as Mediators of Host-Microbial Interactions" ERGOB Meeting 1996 (1996)
  • "Nomenklatur, Atiologie und Pthogenese der marginalen Parodontopathien" 3. Zliner Zhnarztetag (1996)
  • "Lektin-vermittelte Interaktion von oralen Bakterien mit granulozytaren Glykoproteinrezeptoren" Mikroibiologisch-Immunologisches Kolloquium, Hygiene-Institut der Universitat Gottingen (1995)
  • "Bacterial Lectin-Receptors on Human Granulocytes" The Procter & Gamble Company, Worldwide Clinical Investigation - Oral, Regulatory and Clinical Development (1994)
  • "Polymorphonuclear Leukocyte Receptors for Oral Bacterial Lectins" Research Center in Oral Biology, University of Pennsylvania (1994)
  • "Leukosialin: A Granulocyte Receptor for Streptococcal and Actinomyces Lectins" NIH-Interinstitute Glycobiology Interest Group, National Institutes of Health (1994)
  • "Der Interleukin-2 Rezeptor" Klinik fur Zahnarztliche Prothetik, Universitat Bern (1991)
  • "Regulation of IL-2 Receptor Expression on Differentiating Macrophages" Forsyth Dental Center (1991)
  • "Regulation von Interleukin-2 Receptoren vahrend der Makrophagen-Differnzierung" Mikrobiologisch-Immunologisches Kolloquium, Hygiene-Institut der Universitat Gottingen (1991)
  • "The Interleukin-2 Receptor on Haematopoietic Cells" Laboratory of Immunology, National Institute of Dental Research, NIH (1991)
  • "Der Interleukin-2 Rezeptor und seine Rolle im Prozeb der Differenzierung myeloider Zellen" Poliklinik fur Zahnarztliche Chirurgie U. Parodontologie, Eberhard-Karls-Universitat Tubingen (1989)
See all (71 more)

Service Activities:
  • School of Dental Medicine Student Research and Honors Committee; Chair (2015–2018)
  • Oral Biology, School of Dental Medicine Graduate Committee, D.D.S./Ph.D.; Member (2009–2014)
  • Oral Biology, School of Dental Medicine Graduate Committee, Admissions; Member (2009)
  • Oral Biology, School of Dental Medicine Graduate Committee, D.D.S./Ph.D.; Director (2009)
  • School of Dental Medicine Student Research and Honors Committee; Chair (2008–2018)
  • School of Dental Medicine Admissions Committee; Member (2007–2013)
  • Clinical Oral Investigations; Editor-In-Chief (2020–present)
  • Journal of Dental Research; Editorial Board Member (2020–present)
  • Symposium "Preventing Oral Disease at the Intersection of Microbiome and Salivary Proteome"; Chair (2017)
  • Gordon Research Conference on Salivary Glands & Exocrine Secretions; Vice-Chair (2017)
  • GRC Session "Functional Relevance of Mucins and Salivary Proteins"; Chair (2017)
  • Clinical Oral Investigations; Editorial Board Member (2017–present)
  • Buffalo Symposium "Innovations and Controversies in Oral Health...Connecting the Dots from Research to Practice"; Chair (2016)
  • IADR Symposium "Salivary Secretion of the Developing Gland"; Chair (2015)
  • Oral Biology Ph.D. Program; Chair (2015–present)
  • Past President, IADR Salivary Research Group; Past President (2014–2015)
  • IADR Keynote Address; Salivary Gland Organogenesis, Engineering and Evolution; Chair (2014)
  • IADR Symposium: Current Updates on Dry Mouth Diagnosis and Management: Where Are We?; Chair (2014)
  • Organizer and Chair: IADR Salivary Research Group Business Meeting, Cape Town, SA; Chair (2014)
  • IADR/AADR Salivary Research Group; President (2013–2014)
  • IADR Symposium: Novel Approaches to Functional Regeneration of the Salivary Gland; Chair (2013)
  • Organizer: IADR Symposium "Novel Approaches to Functional Regeneration of the Salivary Gland"; Coordinator (2013)
  • Resarch Panel, UB Pre-Health Symposium; Panel Member (2013)
  • Research Panel, UB Prehealth Symposium; Panel Member (2013)
  • IADR/AADR Salivary Research Group; Vice President (2012–2013)
  • AADR Saliva in Health and Disease; Chair (2012)
  • AADR Oral Biology (Seq. #38); Chair (2010)
  • AADR Fellowship Committee; Member (2010–2014)
  • AADR/IADR Salivary Research Group; Committee Member (2010–2012)
  • Organizer of the Department's Seminar Series in Oral Biology Seminar; Coordinator (2009–2012)
  • Salivary Research, Keynote Address and Normal Homeostasis; Co-Chair (2008)
  • Saliva - Biomarkers / Structure and Function; Rochester Oral Biology Research Conference; Co-Chair (2008)
  • Symposium "Saliva - Diagnostic Medium of the Future"; Annual meeting of the German Dental Association, November 22, Dusseldorf, Germany; Chair (2007–2008)
  • Study Group of Basic Sciences; AfG, DGZMK, Mainz, Germany; Chair (2006)
  • Adherence/Adhesion (Seqq. #301.0); 83rd General Session and Exhibition of the International, American and Canadian Associations for Dental Research, Baltimore, MD; Chair (2005)
  • Editorial Board of the Journal of Dental Research; Editorial Board Member (2005–2007)
  • Committee for Therapeutical Drugs; Member (2005–2007)
  • Study Group of Basic Sciences; AfG, DGZMK, Mainz, Germany; Chair (2005)
  • Training for University Teachers in Pediatric Dentistry; Germany; Chair (2004)
  • Caries Risk Management; ConsEuro, Munich, Germany; Chair (2003)
  • Gingival Overgrowth (Seq. #254); 81st General Session and Exhibition of the International Association for Dental Research, Goteborg, Sweden; Chair (2003)
  • Study Group of Basic Sciences; Scientific Program, AfG, DFZMK, Hannover, Germany; Chair (2002)
  • 6th European Symposium on Saliva,; Egmond aan Zee, The Netherlands; Chair (2002)
  • Mechanism of Secretion/Protein Expression (Seq. #45),; 80th General Session and Exhibition of the International Association for Dental Research, San Diego, CA; Chair (2002)
  • Oral Biology of the Child, 8; Jahrestagung der Gesellschaft fur Kinderzahnheilkunde und primarprophyaxe (GKP) in der DGZMK; Chair (2001)
  • Board of Examiners; Final exam for D.D.S. degree; Board Member (2001–2007)
  • Salivary Proteins/Molecules (Seq. #45); 77th General Session and Exhibition of the International Association for Dental Research, Vancouver, Canada; Chair (1999)
  • Microbiology/Immunology I (Seq. #3); 3rd CED/NOF Joint Meeting, Berlin, Germany; Chair (1996)
  • German Research Foundation (DFG); Two article reviews; External Reviewer (1995–2007)
  • Review Activities; Reviewer for the Following Scientific Journals: Clinical Oral Investigation Deutsche Zahnarztliche Zeitschrift Journal of Dental Research European Journal of Oral Sciences Archives of Oral Biology Oral Diseases Caries Research Anatomia Histologia Embryologia J. of Veterinary Medicine Proteomics Planta Medica-Natural Products and Medicinal Plant Research Journal of Pharmacological Sciences Oral Biosciences and Medicine Biomacromolecules Drug Discovery Today Immunological Investigations Journal of Anatomy Journal of Nanoscience and Nanotechnology Journal of Proteome Research; Reviewer (1995–present)

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Contact Information

Department of Oral Biology
University at Buffalo
Foster Hall, Room 213A
Buffalo, NY 14214-3092
Phone: (716) 829-6073
Fax: (716) 829-3942
shruhl@buffalo.edu
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