Ashu Sharma
Ashu Sharma
Education and Training:
- PhD, University of Delhi, India (1988)
- MS, Biochemistry/Endocrinology, University of Delhi, India (1983)
- BS, Zoology, University of Delhi, India (1979)
Employment:
- Professor, Oral Biology, University at Buffalo (2011-present)
- Associate Professor, Oral Biology, University at Buffalo, Oral Biology (2005–2011)
- Assistant Professor (Tenure Track), Oral Biology, State University of New York at Buffalo (1999–2005)
- Assistant Professor (Research), Oral Biology, State University of New York at Buffalo (1994–1998)
- Post Doctoral Fellow, Roswell Park Cancer Institute (1988–1991)
Awards and Honors:
- Advancement for the Dental Research Award, University at Buffalo (2012)
- Principle Investigator Award, University at Buffalo (2005)
- M.Sc. Prakash Memorial Gold Medal, University of Delhi, Delhi (1981)
Grants and Sponsored Research:
- December 2019–November 2024
A role for immune cell plasticity in commensal survival and escalation of inflammation
NIH/NIDCR
Role: Co-Investigator
$1,952,242 - September 2018–August 2023
The role of oral spirochete virulence factors in the impairment of neutrophil response
NIH
Role: Co-Investigator
$1,894,065 - April 2019–April 2021
Oral microbiome in HIV+ opiate users with Thrush
University at Buffalo, BlueSky
Role: Co-Principal Investigator
$5,000 - February 2018–January 2020
Gliding motility in Tannerella forsythia
NIDCR
Role: Principal Investigator
$275 - July 2014–July 2019
T. forsythia TLR2 ligands and surface glycans coordinate periodontal inflammation
NIH/NIDCR
Role: Principal Investigator
$1,250,000 - May 2017–June 2017
GloTran TM plasma cleaner and disinfection testing
YouFirst Inc.
Role: Principal Investigator
$16,629 - May 2014–May 2016
Novel mechanisms of peptidoglycan synthesis in T. forsythia
NIH/NIDCR
Role: Principal Investigator
$325,000 - July 2010–June 2015
Microbial recognition of sialic acid diversity in the salivary proteome
NIH
Role: Contributor - April 2008–March 2013
Tannerella forsythia interactions with host cells and other bacteria
NIH
Role: Principal Investigator
$1,958,980 - April 2003–April 2007
Bacteroides forsythus BspA protein: Role in Virulence.
NIH
Role: Principal Investigator
$700,000 - April 2003–April 2007
B. forsythus BspA protein: Role in Virulence
NIH
Role: Principal Investigator
$175,000 - June 2006–December 2006
Molecular genetic analysis of S. mutans cariogenicity
NIH
Role: Principal Investigator - June 2006–December 2006
Oral Spirochetes-Molecular Genetic Analysis
NIH
Role: Principal Investigator - December 1986–June 2006
Molecular Aspects of PMN Function in Dental Disease
NIH
Role: Co-Investigator
$180,000 - September 1997–September 2002
Streptococcus gordonii as a vector for Porphyromonas gingivalis fimbrillin.
NIH
Role: Principal Investigator
$527,542 - August 1998–July 2000
P. gingivalis fimbrillin expression in S. gordonii.
Siga Pharmaceuticals, New York, NY
Role: Principal Investigator
Journal Articles:
- Dong Y, Zhang C, Frye M, Yang W, Ding D, Sharma A, Guo W, Hu BH. Differential fates of tissue macrophages in the cochlea during postnatal development. Hear Res. 2018; 365.
- Settem RP, Honma K, Shankar M, Li M, LaMonte M, Xu D, Genco RJ, Browne RW, Sharma A. Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes. Mol Oral Microbiol. 2018; 33(4).
- Ruscitto A, Sharma A. Peptidoglycan synthesis in Tannerella forsythia: Scavenging is the modus operandi. Mol Oral Microbiol. 2018; 33(2).
- Honma K, Ruscitto A, Sharma A. β-glucanase activity of the oral bacterium Tannerella forsythia contributes to the growth of a partner species, Fusobacterium nucleatum, in co-biofilms. Appl Environ Microbiol. 2018.
- Ruscitto A, Honma K, Veeramachineni VM, Nishikawa K, Stafford GP, Sharma A. Regulation and Molecular Basis of Environmental Muropeptide Uptake and Utilization in Fastidious Oral Anaerobe Tannerella forsythia. Front Microbiol. 2017; 8.
- Friedrich V, Janesch B, Windwarder M, Maresch D, Braun ML, Megson ZA, Vinogradov E, Goneau MF, Sharma A, Altmann F, Messner P, Schoenhofen IC, Schäffer C. Tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications. Glycobiology. 2017; 27(4).
- Chinthamani S, Settem RP, Honma K, Kay JG, Sharma A. Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia. PLoS One. 2017; 12(3).
- Vinogradov E, St Michael F, Homma K, Sharma A, Cox AD. Structure of the LPS O-chain from Fusobacterium nucleatum strain 10953, containing sialic acid. Carbohydr Res. 2017; 440-4.
- Stafford GP, Chaudhuri RR, Haraszthy V, Friedrich V, Schäffer C, Ruscitto A, Honma K, Sharma A. Draft Genome Sequences of Three Clinical Isolates of Tannerella forsythia Isolated from Subgingival Plaque from Periodontitis Patients in the United States. Genome Announc. 2016; 4(6).
- Ruscitto A, Hottmann I, Stafford GP, Schäffer C, Mayer C, Sharma A. Identification of a Novel N-Acetylmuramic Acid Transporter in Tannerella forsythia. J Bacteriol. 2016; 198(22).
- Honma K, Ruscitto A, Frey AM, Stafford GP, Sharma A. Sialic acid transporter NanT participates in Tannerella forsythia biofilm formation and survival on epithelial cells. Microb Pathog. 2016; 94.
- Zheng W, Tsompana M, Ruscitto A, Sharma A, Genco R, Sun Y, Buck MJ. An accurate and efficient experimental approach for characterization of the complex oral microbiota. Microbiome. 2015; 3.
- Settem RP, Honma K, Sharma A. Neutrophil mobilization by surface-glycan altered Th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss. PLoS One. 2014; 9(9).
- Amano A, Chen C, Honma K, Li C, Settem RP, Sharma A. Genetic characteristics and pathogenic mechanisms of periodontal pathogens. Adv Dent Res. 2014; 26(1).
- Settem RP, Honma K, Nakajima T, Phansopa C, Roy S, Stafford GP, Sharma A. A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression. Mucosal Immunol. 2013; 6(2).
- Myneni SR, Settem RP, Sojar HT, Malone JP, Loimaranta V, Nakajima T, Sharma A. Identification of a unique TLR2-interacting peptide motif in a microbial leucine-rich repeat protein. Biochem Biophys Res Commun. 2012; 423(3).
- Settem RP, El-Hassan AT, Honma K, Stafford GP, Sharma A. Fusobacterium nucleatum and Tannerella forsythia Induce Synergistic Alveolar Bone Loss in a Mouse Periodontitis Model. Infect Immun. 2012; 80(7).
- Roy S, Phansopa C, Stafford P, Honma K, Douglas CW, Sharma A, Stafford GP. Beta-hexosaminidase activity of the oral pathogen Tannerella forsythia influences biofilm formation on glycoprotein substrates. FEMS Immunol Med Microbiol. 2012; 65(1).
- Stafford G, Roy S, Honma K, Sharma A. Sialic acid, periodontal pathogens and Tannerella forsythia: stick around and enjoy the feast! Mol Oral Microbiol. 2012; 27(1).
- Sharma A. Streptococcus cristatus ArcA interferes with Porphyromonas gingivalis pathogenicity in mice. J Periodontal Res. 2012.
- Roy S, Honma K, Douglas CW, Sharma A, Stafford GP. Role of sialidase in glycoprotein utilization by Tannerella forsythia. Microbiology. 2011; 157(Pt 11).
- Mishima E, Sharma A. Tannerella forsythia invasion in oral epithelial cells requires phosphoinositide 3-kinase activation and clathrin-mediated endocytosis. Microbiology. 2011; 157(Pt 8).
- Myneni SR, Settem RP, Connell TD, Keegan AD, Gaffen SL, Sharma A. TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. J Immunol. 2011; 187(1).
- Hall LM, Dunford RG, Genco RJ, Sharma A. Levels of Serum IgG Specific to the BspA Protein of Tannerella Forsythia are Related to the Periodontal Status. J Periodontol. 2011.
- Honma K, Mishima E, Sharma A. Role of Tannerella forsythia NanH sialidase in epithelial cell attachment. Infect Immun. 2011; 79(1).
- Sharma A. Virulence mechanisms of Tannerella forsythia. Periodontol 2000. 2010; 54(1).
- Sahingur, S.E., Xia, X. J, Alamgir, S, Honma, K., Sharma, A, Schenkein, H. DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines. Mol Oral Microbiol. 2010; 25(2).
- Honma K, Mishima E, Inagaki S, Sharma A. The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. Microbiology. 2009; 155(Pt 6).
- Loimaranta V, Hytonen J, Pullianen AT, Sharma A, Tenovuo J, Stromberg N, Finne J. Leucine rich repeats of bacterial surface proteins serve as common pattern recognition motifs of human scavenger receptor Gp340 J Biol Chem. 2009; 284.
- Morozumi T, Sharma A, DeNardin E. The functional effects of the -455G/A polymorphism on the IL-6-induced expression of the beta-fibrinogen gene may be due to linkage disequilibrium with other functional polymorphisms. Immunol Invest. 2009; 38(3-4).
- Morotsumi T, Sharma A, DeNardin E. The effect of gene polymorphisms on the interleukin 6-induced transcriptional activity the β-fibrinogen promoter region. Thrombosis Research. 2008.
- Onishi S, Honma K, Liang S, Stathopoulou P, Kinane D, Hajishengallis G, Sharma A. TLR2-Mediated Interleukin-8 Expression in Gingival Epithelial Cells by the Tannerella forsythia Leucine-Rich Repeat BspA Protein. Infect Immun. 2008; 76.
- Honma K, Inagaki S, Okuda K, Kuramitsu HK, Sharma A. Role of a Tannerella forsythia Exopolysaccharide Synthesis Operon in Biofilm Development. Microbial Pathogenesis. 2007; 42.
- Sahingur SE, Boehm TK, Sojar H, Sharma A, DeNardin E. Fibrinogen-neutrophil Interactions in Response to fMLP and Porphyromonas gingivalis Fimbrial Peptides. Immunol Invest. 2006; 35.
- Chen W, Honma K, Sharma A, Kuramitsu HK. A Universal Stress Protein of Porphyromonas gingivalis is Involved in Stress Responses and Biofilm Formation. FEMS Microbiol Letter. 2006; 264.
- Inagaki S, Onishi S, Kuramitsu H, Sharma A. Porphyromonas gingivalis Vesicles Enhance Attachment and the Leucine-Rich Repeat BspA Protein is Required for Invasion of Epithelial Cells by Tannerella forsythia. Infect Immun. 2006; 74.
- Inagaki S, Kuramitsu H, Sharma A. Contact Dependent Regulation of a Tannerella forsythia Virulence Factor, BspA, in Biofilms. FEMS Microbiol Letters. 2005; 249.
- Sharma A, Inagaki S, Honma K, Sfintescu C, Baker P, Evans R. Alveolar Bone Loss in Mice Involves Leucine-Rich Repeat BspA Protein. J Dent Res. 2005; 84.
- Sharma A, Inagaki S, Sigurdson W, Kuramitsu H. Synergy Between Tannerella forsythia and Fusobacterium nucleatum in Biofilm Formation. Oral Microbiol Immunol. 2005; 20.
- Sojar HT, Sharma A, Genco RJ. Porphyromonas gingivalis Fimbriae Binds to Neoglycoproteins: Evidence for a Lectin-Like Interaction. Biochimie. 2004; 86(4-5).
- Ruddy MJ, Shen F, Smith JB, Sharma A, Gaffen S. Interleukin-17 Regulates Expression of the CXC Chemokine LIX/CXCL5 in Osteoblasts: Implications for Inflammation and Neutrophil Recruitment.. J Leukoc Biol. 2004; 6.
- Sojar H, Sharma A, Genco RJ. Porphyromonas gingivalis fimbriae binds neoglycoproteins: Evidence for a lectin like interaction. Bochimie. 2004; 86.
- Ikegami A, Honma K, Sharma A, Kuramitsu H. Multiple Functions of the Leucine-Rich Repeat Protein (LrrA) of Treponema denticola. Infect Immun. 2004; 72.
- Sojar H, Sharma A, Genco RJ. Porphyromonas gingivalis Fimbriae Binds to Neoglycoproproteins: Evidence for a Lectin-Like Interaction. Biochimie. 2004; 86.
- Sahingur SE, Sharma A, Genco RJ, DeNardin E. Association of Increased Levels of Fibrinogen and the -455G/A Fibrinogen Gene Polymorphism with Chronic Periodontitis. J Periodontol. 2003; 74.
- Sahingur SE, Sharma A, Genco RJ, DeNardin E. Association of Increased Levels of Fibrinogen and the -455G/A Fibrinogen Gene Polymorphism with Chronic Periodontitis. J Periodontol. 2003; 74.
- Hajishengallis G, Sharma A, Russell MW, Genco RJ. Interactions of Oral Pathogens with Toll-Like Receptors: Possible Role in Atherosclerosis. Ann Periodontol. 2002; 27(1).
- Hajishengallis G, Martin M, Sojar H, Sharma A, Schifferle R, DeNardin E, Russell MW, Genco RJ. Dependence of Bacterial Protein Adhesins on Toll-Like Receptors for Proinflammatory Cytokine Induction. Clinical and Diagnostic Laboratory Immunology. 2002; 9(2).
- Sojar H, Sharma A, Genco RJ. Porphyromonas gingivalis Fimbriae Bind to Cytokeratin of Epithelial Cells. Infection and Immunity. 2002; 70(01).
- Hajishengallis G, Martin M, Sojar H, Sharma A, Schifferle R, DeNardin E, Russell MW, Genco RJ. Dependence of bacterial protein adhesin on toll-like receptors and proinflammatory cytokine induction. Clin Diagn Lab Immunol. 2002; 9(2).
- Sojar H, Sharma A, Genco RJ. Porphyromonas gingivalis fimbriae bind to cytokeratin of epithelial cells. Infect Immun. 2002; 70.
- Hajishengallis H, Sharma A, Russell MW, Genco R. Interactions of Oral Pathogens With Toll-Like Receptors: Possible Role in Atherosclerosis. Ann Periodontol. 2002; 7.
- Hajishengallis H, Martin M, Sojar H, Sharma A, Schifferle R, DeNardin E, Russell MW, Genco RJ. Dependence of Bacterial Protein Adhesion on Toll-Like Receptors for Proinflammatory Cytokine Induction. Clin Diagn Lab Immunol. 2002; 9.
- Sojar H, Sharma A, Genco RJ. Porphyromonas gingivalis Fimbriae Bind to Cytokeratin of Epithelial Cells. Infect Immun. 2002; 70.
- Honma K, Kuramitsu H, Genco RJ, Sharma A. Development of a Gene Inactivation System for Bacteroides forsythus Construction and Characterization of a BspA Mutant. Infection and Immunity. 2001; 69(07).
- Sharma A, Kiyonobu H, Evans R, Hruby DE, Genco RJ. Oral Immunization with Recombinant Streptococcus gordonii Expressing Porphyromonas gingivalis FimA Domains. Infection and Immunity. 2001; 69(05).
- Honma K, Kuramitsu H, Genco RJ, Sharma A. Development of a Gene Inactivation System for Bacteroides forsythus: Construction and Characterization of a BspA Mutant. Infect Immun. 2001; 69.
- Sharma A, Honma K, Evans R, Hruby DE, Genco RJ. Oral Immunization with Recombinant Streptococcus gordonii Expressing Porphyromonas gingivalis FimA Domains. Infect Immun. 2001; 69.
- Katancik JA, Sharma A, de Nardin E, DeNardin E. Interleukin 8, neutrophil-activating peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR2. Cytokine. 2000; 12(10).
- Sharma A, Novak EK, Sojar H, Swank RT, Kuramitsu H, Genco RJ. Porphromonas gingivalis Platelet Aggregation Activity: Outer Membrane Vesicles Are Potent Activators. Oral Microbiology and Immunology. 2000; 15.
- Sharma A, Novak EK, Sojar H, Swank RT, Kuramitsu HK, Genco RJ. Porphyromonas gingivalis platelet aggregation activity: outer membrane vesicles are potent activator. Oral Microbiol Immunol. 2000; 15.
- Sharma A, Novak EK, Sojar H, Swank RT, Kuramitsu H, Genco RJ. Porphyromonas gingivalis Platelet Aggregation Activity: Outer Membrane Vesicles are Potent Aggregates of Murine Platelets. Oral Microbiol Immunol. 2000; 15.
- Katancik JA, Sharma A, DeNardin E. Interleukin-B, Neutrophil-Activating Peptide-2, and GRO-a Bind to Elicit Cell Activation Via Specific and Different Amino Acid Residues of CXCR. Cytokine. 2000; 12.
- Guo M, Han Y, Sharma A, DeNardin E. Identification and Characterization of Human Immunoglobulin G Fc Receptors of Fusobacterium nucleatum. Oral Microbiol Immunol. 2000; 15.
- Sojar H, Yiping H, Hamada N, Sharma A, Genco RJ. Role of the Amino-Terminal Region of Porphyromonas gingivalis Fimbriae in Adherence to Epithelial Cells. Infection and Immunity. 1999; 67(11).
- Sojar H, Hany Y, Hamada N, Sharma A, Genco RJ. Role of amino-terminal region of Porphyromonas gingivalis fimbriae in adherence to epithelial cells. Infect Immun. 1999; 67.
- Sharma A, Honma K, Sojar H, Hruby D, Kuramitsu H, Genco RJ. Expression of saliva-binding epitopes of porphyromonas gingivalis fimA protein on the surface of streptococcus gordinii. Biochem Biophys Res Commun. 1999; 258.
- Sharma A, Sojar H, Hruby DE, Kuramitsu H, Genco R. Expression of Saliva-Binding Epitopes of the Porphyromonas gingivalis FimA Protein on the Surface of Streptococcus gordonii. Biochem Biophys Res Comm. 1999; 258.
- Sojar H, Han Y, Hamada N, Sharma A, Genco RJ. Role of Amino Terminal Region of Porphyromonas gingivalis Fimbriae in Adherence of Epithelial Cells. Infect Immun. 1999; 67.
- Gwinn M, Sharma A, DeNardin E. Single Nucleotide Polymorphisms of the N-Formyl Peptide Receptor in Localized Juvenile Periodontitis. J Periodontol. 1999; 70.
- Sharma A, Sojar H, Glurich I, Honma K, Kuramitsu H, Genco RJ. Cloning, Expression, and Sequencing of a Cell Surface Antigen Containing a Leucine-Rich Repeat Motif from Bacteroides forsythus ATCC 43037. Infection and Immunity. 1998; 66(12).
- Sharma A, Sojar H, Glurich I, Honma K, Kuramitsu HK, Genco RJ. Cloning, expression and sequencing of a cell-surface antigen containin a leucine-rich repeat motf from Bacteroides forsythus ATCC43037.. Infect Immun. 1998; 66.
- Sharma A, Sojar H, Glurich I, Honma K, Kuramitsu H, Genco RJ. Cloning, Expression, and Sequencing of a Cell Surface Antigen Containing a Leucine-Rich Repeat Motif from Bacteroides forsythus ATCC 43037. Infect Immun. 1998; 66.
- Amano A, Fujiwara T, Nagata H, Kuboniwa M, Sharma A, Sojar H, Genco RJ, Hamada S, Shizukuishi S. Porphyromonas gingivalis Fimbriae Mediate Coaggregation with Streptococcus oralis Through Specific Domains. J Dent Res. 1997; 76(4).
- Nagata H, Sharma A, Sojar HT, Amano A, Levine MJ, Genco RJ. Role of carboxyl-terminal region of Porphyromonas gingivalis fimbrillin in the binding to salivary proteins.. Infect Immun. 1997; 65(2).
- Sharma A, Sojar H, Hruby DE, Kuramitsu H, Genco RJ. Secretion of Porphyromonas gingivalis Fimbrillin Polypeptides by Recombinant Streptococcus gordonii. Biochemical and Biophysical Research Communications. 1997; 238.
- Sharma A, Sojar H, Hruby DE, Kuramitsu H, Genco R. Secretion of Porphyromonas gingivalis Fimbrillin Polypeptides by Recombinant Streptococcus gordonii. Biophys Res Commun. 1997; 238.
- Katancik JA, Sharma A, Radel SJ, DeNardin E. Mapping of the Extracellular Binding Region of the Human Interleukin-8 Receptor. Biochem Biophys Res Commun. 1997; 232.
- Amano A, Fujiwara T, Nagata H, Kuboniwa M, Sharma A, Sojar H, Genco RJ. Porphyromonas gingivalis Fimbriae Mediate Coaggregation with Streptococcus oralis Through Specific Domains. J Dent Res. 1997; 76.
- Sharma A, Nagata H, Hamada N, Sojar H, Hruby DE, Kuramitsu H, Genco RJ. Expression of Functional Porphyromonas gingivalis Fimbrillin Polypeptide Domains on the Surface of Streptococcus gordonii. Applied and Environmental Microbiology. 1996; 62(11).
- Amano A, Sharma A, Lee J-Y, Sojar H, Periathamby A, Genco RJ. Structural Domains of Porphyromonas gingivalis Recombinant Fimbrillin that Mediate Binding to Salivary Proline-Rich and Statherin. Infection and Immunity. 1996; 64(5).
- Sharma A, Nagata H, Hamada N, Sojar H, Hruby DE, Kuramitsu H, Genco R. Expression of Functional Porphyromonas gingivalis Fimbrillin Polypeptide Domains on the Surface of Streptococcus gordonii. Appl Environ Microbiol. 1996; 62.
- Sharma A, O‘Connell BC, Tabak LA, Bedi GS. Expression of a Functional Rat Salivary Cystatin Polypeptide in Escherichia coli. Arch Oral Biol. 1995; 40.
- Sharma A, Ahmed H, Allen HJ. Isolation of a Melibiose-Binding Protein from Human Spleen. Glycoconjugate. 1995; 12.
- Brant E, Sojar H, Sharma A, Bedi GS, Genco RJ, DeNardin E. Identification of Linear Antigenic Sites on the Porphyromonas gingivalis 43 kDa Fimbrillin Subunit. Oral Microbiology and Immunology. 1995; 14.
- Amano A, Sojar HT, Lee J-Y, Sharma A, Levine MJ, Genco RJ. Salivary receptors for recombinant fimbrillin of Porphyromonas gingivalis.. Infect Immun. 1994; 62(8).
- Amano A, Sharma A, Sojar H, Kuramitsu H, Genco RJ. Effects of Temperature Stress on Expression of Fimbriae and Superoxide Dismutase by Porphyromonas gingivalis. Infection and Immunity. 1994; 62.
- Brant EE, Sojar H, Sharma A, Bedi GS, Genco RJ, DeNardin E. Identification of Linear Antigenic Sites on the Porphyromonas gingivalis 43-kDA Fimbrillin Subunit. Oral Microbiol Immunol. 1994; 9.
- Amano A, Sharma A, Sojar H, Kuramitsu H, Genco RJ. Effect of Temperature Stress on the Expression of Fimbriae and Superoxide Dismutase in Porphyromonas gingivalis. Infect Immun. 1994; 62.
- Sharma A, Sojar H, Lee J-Y, Genco RJ. Expression of Functional Porphyromonas gingivalis Fimbrillin Polypeptide in E. coli: Purification, Physiochemical & Immunochemical Characterization, and Binding Characteristics. Infection and Immunity. 1993; 61(8).
- Lala A, Sharma A, Sojar H, Radel SJ, Genco RJ, DeNardin E. Recombinant Expression and Partial Characterization of the Human Formyl Peptide Receptor. Biochimica et Biophysica Acta. 1993.
- Allen HJ, Sharma A, Ahmed H, Piver MS, Gammara M. Galaptin and Galaptin-Binding Conjugates in Sera and Effusions of Carcinoma Patients. Tumour Biol. 1993; 14.
- Lala A, Sharma A, Sojar H, Radel RJ, Genco RJ, DeNardin E. Recombinant Expression and Partial Characterization of the Human Formyl Peptide Receptor. Biochimica et Biophysica Acta. 1993; 1178.
- Sharma A, Sojar H, Lee J-Y, Genco RJ. Expression of a Functional Porphyromonas gingivalis Fimbrillin Polypeptide in E. coli: Purification, physicochemical and Immunochemical Characterization, and Binding Characteristics. Infect Immun. 1993; 61.
- Lee J-Y, Sojar H, Sharma A, Bedi GS, Genco RJ. Active Domains of Fimbrillin Involved in Adherence of Porphyromonas gingivalis. J Periodont Res. 1993; 28.
- Allen HJ, Ahmed H, Sharma A. Isolation of Lactose-Binding Lectins from Axolotl (Ambystoma mexicanum). Comp Biochem Physiol. 1992; 103B.
- Ahmed H, Sharma A, DiCioccio RA, Allen HJ. Lymphoblastoid Cell Adhesin Mediated by a Dimeric and Polymeric Endogenous B-Galactoside-Binding Lectin (Galaptin). J Molec Recog. 1992; 5.
- Sharma A, DiCioccio RA, Allen HJ. Isolation and Characterization of a Novel 15 kD B-Galactoside Binding Lecin from Human Spleen. Glycobiology. 1992; 2.
- Sharma A, Malhotra P, Duraiswami S. Ind J Biochem Biophys. 1991; 28.
- Allen HJ, Gottestine S, Sharma A, DiCioccio R, Swank RT, Li H. Synthesis, Isolation and Characterization of Endogenous B-Galactoside Binding Lectin in Human Leucocytes. Biochemistry. 1991; 30.
- Allen HJ, Gammara M, Piver MS, Sharma A, Ahmed H, Johnson AJ. Synthesis and Release of Cell Surface Derived and Sulfated Lactosaminoglycans by Human Ovarian Carcinoma Cells. Cancer Biochem Biophys. 1991; 12.
- Allen HJ, Sharma A, Matta AK. Synthesis and Carbohydrate-Binding Activity of Polyethyleneglycol-Ricinus Cummunis Agglutintin I Conjugates. Carbohydrate Res. 1991; 213.
- Ahmed H, Allen HJ, Sharma A, Matta KL. Human Splenic Galaptin: Carbohydrate-Binding Specificity and Characterization of the Combining Site. Biochemistry. 1990; 29.
- Sharma A, Chemelli R, Allen HJ. Human Splenic Galaptin: Physicochemical Characterization. Biochemistry. 1990; 29.
- Allen HJ, Sucato D, Woynmarowska B, Gottstine S, Sharma A, Bernacki RJ. Role of Galaptin in Ovarian Carcinoma Adhesion to Extracellular Matrix In Vitro. J Cell Biochem. 1990; 43.
- Allen HJ, Sucato D, Woynarowska B, Gottstine S, Sharma A, Bernacki RJ. Role of Galaptin in Ovarian Carcinoma Adhesion to Extracellular Matrix In vitro.. Glycobiology. 1990; 111.
Books and Book Chapters:
- Genco RJ, Sojar H, Lee J-Y, Sharma A, Bedi G, Cho M, Dyer DW. Porphyromonas gingivalis Fimbriae: Structure, Function, and Insertional Inactivational Mutants. In: Molecular Pathogenesis of Periodontal Diseases. 1994.
- Genco RJ, Sojar H, Lee, J-Y, Sharma A, Bedi, GS, Cho M, Dyer, DW. Porphyromonas gingivalis. Fimbriae: Structure, Function and Insertional Inactivation Mutants.. Molecular Pathogenesis of Periodontal Disease. 1994; (2).
- Allen HJ, Sharma A, Kisailus EC. Isolation of Galaptin, SDS-PAGE, Peptide Preparation and Binding Site Specificity.. Lectins in Cell Biology..
Abstracts:
- Rogers SC, Keinan D, Baier R, Mang T, Honma K, Sharma A. Examination of periodontal pocket biofilm growth and effects of PDT for perio-infection control. J Dent Res. 2013.
- Hall L, Dunford R, Genco RJ, Sharma A. Humoral Immune Response to Tannerella Forsythia's Virulence Factor BspA. J Dent Res. 2010.
- Mishima E, Sharma A. Molecular mechanisms of Tannerella forsythia invasion into epithelial cells. J Dent Res. 2010; 89.
- Myeni Venkatasatya S, Settem P, Sojar HT, Sharma A. Functional epitopes of Tannerella forsythia BspA protein in TLR2 activation. J Dent Res. 2010; 89.
- Sahingur SE, Alamgir S, Honma K, Sharma A, Schenkein HA. Periodontal bacterial DNA-mediated cytokine induction from human monocytic cells. J Dent Res. 2009; 88.
- Onishi S, Honma K, Sharma A. TLR2-mediated epithelial cell activation by the Tannerella forsythia BspA protein. J Dent Res. 2008; 87.
- Honma K, Perry MJ, Sharma A. Characterization of OxyR homologue of Tannerella forsythia. J Dent Res. 2008; 87.
- Sharma A, Onishi, S, Inagaki, S, Honma, K. Toll-Like Receptor 2 Activation by Tannerella forsythia BspA Protein: Structure. Gordon Conference on Periodontal Disease, Italy. J Dent Res. 2006.
- Inagaki S, Kuramitsu H, Sharma A. Contact-Dependent Regulation of Leucine-Rich Repeat BspA Protein of Tannerella forsythia. IADR/AADR/CADR 83rd General Session (March 9-12, 2005). J Dent Res. 2005.
- Honma K, Inagaki S, Ishihara K, Okuda K, Kuramitsu H, Sharma A. Analyses of Tannerella forsythia Genes Involved in Biofilm Growth. IADR/AADR/CADR 83rd General Session (March 9-12, 2005). J Dent Res. 2005.
- Onishi S, Inagaki S, Honma K, Sharma A. TLR2 Activation by Tannerella forsythia BspA Protein; Role of TLR1. IADR/AADR/CADR 83rd General Session (March 9-12, 2005). J Dent Res. 2005.
- Sharma A, Kuramitsu H. Synergistic Oral Biofilm Formation by Periodontopathic Fusobacterium nucleatum and Bacteroides forsythus. American Society for Microbiology Conference on Biofilms. Victoria, British Columbia, Canada. 2003.
- Ovrutsky D, Genco RJ, Sharma A. The Leucine-Rich Repeat Domain (LRR) of Bacteroides forsythus BspA Protein is Responsible for Activation on Monocyctic Cells. IADR Meeting, San Diego, CA. J Dent Res. 2002.
- Sharma A, Neelamegham HT, Sojar H, Genco RJ. The Leucine-Rich Repeat Domain of Bacteroides forsythus (Tannerella forsythensis) BspA Protein Binds A- and B-Chains of Fibrinogen: Role in Platelet Function. IADR Meeting, San Diego, CA. J Dent Res. 2002.
- Hajishengallis G, Sojar H, Sharma A, Martin M, DeNardin E, Genco RJ. TLR-4 Dependent Upregulation of Costimulatory Molecules in Macrophages by P. gingivalis FimA. IADR Meeting, San Diego, CA. J Dent Res. 2002.
- Sojar H, Sharma A, Martin, M., Schifferle R, DeNardin E, Genco RJ. Host Regulatory Interactions Between P. gingivalis Fimbriae and LPS.. J Dent Res. 2001; 80SI(578).
- Hajishengallis, G, Sojar H, Sharma A, Martin, M, Schifferle R, DeNardin E, Genco RJ. Host Regulatory Interactions Between P. gingivalis Fimbriae and LPS. IADR Meeting in Chiba, Japan. J Dent Res. 2001.
- Sharma A, Sojar H, Novak EK, Swank RT, Kuramitsu H, Genco RJ. Identification of a Putative Gene Encoding Porphyromonas gingivalis Platelet-Aggregation Associated Protein (PgPAAP). IADR Meeting at Vacouver, Canada. J Dent Res. 1999.
- Honma K, Sharma A, Sojar H, Genco RJ. Purification of Cell Surface Associated Protein of Bacteroides forsythus. J Dent Res. 1999; 78.
- Ming G, Han Y, Sharma A, DeNardin E. Characterization of the Human IgG Fc Receptor of Fusobacterium nucleatum. IADR Meeting at Vancouver, Canada. J Dent Res. 1999; 78.
- Sojar H, Han Y, Hamada N, Sharma A, DeNardin E. Role of the Amino Terminal Region of Porphyromonas gingivalis Fimbriae in Adherence to Epithelial Cells.. J Dent Res. 1999; 78.
- Gwinn M, Lewins MR, Sharma A, DeNardin E. Sequence Analysis of the Interleukin-8 (IL-8) Receptor in Localized Juvenile Periodontitis. J Dent Res. 1999; 78.
- Sahingur SE, Gwinn MR, Sharma A, DeNardin E. Restriction Fragment Length Polymorphism in the Promoter Region of B-Fibrinogen Gene in Adult Periodontitis Patients and Healthy Subjects. J Dent Res. 1999; 78.
- Katancik JA, Sharma A, DeNardin E. Point Mutagenesis Studies of the Human Neutrophil CXC Chemokine Receptor-2. J Dent Res. 1999; 78.
- Guo, M, Han, YP, Sharma A, DeNardin E. Characterization of the Human IgG Fc Receptors of Fusobacterium nucleatum. J Dent Res. 1999; 78.
- Katancik, JA, Sharma A, DeNardin E. Point Mutagenesis Studies of the Human Neutrophil CXC Chemokine Receptor-2. J Dent Res. 1999; 78.
- Gwinn, MR, Lewins, SN, Sharma A, DeNardin E. Sequence Analysis of the Interleukin-8 (IL-8) Receptor in Localized Juvenile Periodontitis. J Dent Res. 1999; 78.
- Sahingur, SE, Gwinn, MR, Sharma A, DeNardin E. Restriction Fragment Length Polymorphisms in the Promoter Region of the B-Fibrinogen Gene in Adult Periodontitis Patients and Healthy Subjects. J Dent Res. 1999; 78.
- Sharma A, Sojar H, Hruby DE, Kuramitsu H, Evans R, Genco RJ. Recombinants of Streptococcus gordonii Express Functional Domains of Porphyromonas gingivalis Fimbrillin. 76th IADR Meeting, Nice, France. J Dent Res. 1998; 77.
- Sharma A, Novak, E, McGarry, M, Swank, RT, Kuramitsu H, Genco RJ. Characterization of Porphyromonas gingivalis-Induced Platelet Aggregation. ASM Conference on Microbes, Haemostasis and Vascular Biology, March 29 - April 1, 1998 at Gaveston, TX. 1998.
- Gwinn M, Sharma A, DeNardin E. Sequence Analysis of Chemotactic Receptor DNA in Localized Juvenile Periodontitis. IADR Meeting in Nice, France. J Dent Res. 1998.
- Katancik, JA, Sharma A, DeNardin E. Point Mutagenesis Studies of the Human Interleukin-8 Type B Receptor. AADR Minneapolis Meeting. J Dent Res. 1998.
- Gwinn M, Sharma A, DeNardin E. Sequence Analysis of FMLP Receptor DNA in LJP. J Dent Res. 1998.
- Sharma A, Hamada N, Sfintescu C, Nagata N, Sojar H, Kuramitsu H, Evans R, Genco RJ. Recombinant S. gordonii Expressing P. gingivalis Fimbrillin as Vectors for Immunization Against Periodontal Disease. AADR Meeting, Orlando, FL. J Dent Res. 1997.
- Gwinn, M, Sharma A, DeNardin E. Single Strand Conformation Polymorphism Analysis of FMLP Receptor-Encoding DNA. J Dent Res. 1997; 76.
- Gwinn, M, Sharma A, DeNardin E. Single Strand Conformation Polymorphism Analysis of the FMLP Receptor. J Dent Res. 1996; 75.
- Gwinn, M, Sharma A, DeNardin E. Single Strand Conformation Polymorphism Analysis of FMLP Receptor DNA. 22nd Annual Maine Biological and Medical Sciences Symposium. The University of Maine at Orono. 1996.
- Lala, A, Sharma A, Sojar H, Radel, SJ, Genco RJ, DeNardin E. Cloning and Expression of FMLP Receptor in E. coli. International Association for Dental Research, Chicago, IL. J Dent Res. 1993.
- Amano A, Sojar H, Lee JY, Sharma A, Levine MJ, Genco RJ. Salivary components promote the attachment of p.gingivalis recombinant fimbrillin protein to hydroxyapatite.. J Dent Res. 1993.
Professional Memberships:
- Member, American Association for the Advancement of Science (AAAS) (2006–present)
- Member of Advisory Group, Oralgen Data Base at the Los Alamos National Laboratories; This is a consortium formed by the NIDCR (NIH) and the Los Alamos Labs to advise on genomic approaches for the study of oral bacteria and their role in pathogenesis. (2005–present)
- Member, American Association for Dental Research (2000–present)
- Member, American Society for Microbiology and AAAS (2000–present)
Presentations:
- "T. forsythia surface layer glycosylation and BspA modulate host immunity" First International conference on P. gingivalis and related bacterial species, Nagasaki University (2013)
- "Tannerella forsythia surface glycosylation: a strategy for manipulating host immunity" Oral Microbiome, Immunity & Chronic Disease, University at Buffalo (2013)
- "The role of Tannerella forsythia leucine-rich-repeat BspA protein in epithelial cell interactions" Gordon Conference on Periodontal Disease (2006)
- "Invited Speaker" Houston Medical Sciences Center, University of Texas at Houston, Dental Division (1999)
- "Novel oral streptococccal vaccine vectors" (1999)
Service Activities:
- School of Dental Medicine Promotion and Tenure Committee; Member (2014–2015)
- Oral Biology, School of Dental Medicine Graduate Committee, D.D.S./Ph.D.; Director (2010–2015)
- School of Dental Medicine Student Research and Honors Committee; Member (2002–2015)
- Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (1999–2001)
- Oral Biology, School of Dental Medicine Graduate Committee, Thesis; Member (1999)
- Oral Biology, School of Dental Medicine Graduate Committee, D.D.S./Ph.D.; Member (1998)
- Oral Biology, School of Dental Medicine Graduate Committee, Admissions; Member
- Judge; Poster Judging at UB Postdoc symposium (2015)
- Reviewer/multiple journals; Manuscript reviewing; Reviewer (2015)
- Ad Hoc Reviewer, Archives of Oral Biology; Ad Hoc Reviewer (2008–present)
- Ad Hoc Reviewer, Journal of Clinical Periodontology; Ad Hoc Reviewer (2008–present)
- Ad Hoc Reviewer, Gene; Ad Hoc Reviewer (2007–present)
- Ad Hoc Reviewer, Journal of Thrombosis and Haemostasis; Ad Hoc Reviewer (2007–present)
- Ad Hoc Reviewer, Odontology; Ad Hoc Reviewer (2007–present)
- Ad Hoc Reviewer, Journal of Periodontology; Ad Hoc Reviewer (2006–present)
- Journal Reviewer, FEMS Microbiology & Immunology; Reviewer (2006–present)
- Journal Reviewer, Microbiology; Reviewer (2006–present)
- Journal Reviewer, Vaccine Journal; Reviewer (2006–present)
- IGBBS-member; recruit students for program; Member (2002–2005)