N.I.H. Physician Scientist Award, SUNY at Buffalo (1984)
N.I.H. Training Grant, Harvard University (1981)
American College of Dentists Award, SUNY at Buffalo (1981)
Senior Dental Student Award, SUNY at Buffalo (1981)
William Tucker Dental Scholarship, SUNY at Buffalo (1981)
American Institute of Chemists Award, Buffalo State College (1971)
New York State Regents Scholarship, Buffalo State College (1967)
Research Expertise:
Clinical research-periodontal disease
Surface antigens of porphyromonas gingivalis
Grants and Sponsored Research:
January 2016–January 2021 Pilot Study of the Oral Microbiome in Subjects with Type 2 Diabetes and Periodontal Disease Sunstar Incorporated Role: Co-Investigator
September 2010–September 2016 Biomarkers of Periodontal Disease Progression NIH Role: Co-Investigator $1,135,851
April 2008–March 2013 Tannerella forsythia interactions with host cells and other bacteria NIH Role: Co-Investigator $1,958,980
October 2011–October 2012 Effects of a Mouthwash Containing Chlorine Dioxide on Bacterial Plaque BASF Venture Capital America Inc. Role: Co-Investigator $187,853
January 2010–June 2011 Screening of Patients in a Dental Setting for Undiagnosed Diabetes Mellitus and Prediabetes Delta Dental of Rhode Island Role: Co-Investigator $237,142
October 2005–December 2010 A 9-month Clinical Trial of Treatment with Periocline 2 Minocycline for Adjunctive Use to Scaling - Training and Calibration Sunstar Role: Co-Investigator $84,520
December 2007–November 2010 A comparison of tghe Systemic Exposure of Subgingivally Applied Periocline Gel as an Adjunct to Scaling and Root Planing Sunstar Role: Co-Investigator $111,636
March 2008–December 2009 Effect of Chewing Gum on Gingivitis and Inflammatory Markers Wrigley Role: Co-Investigator $166,580
December 1996–November 1997 Clinical Evaluation of Bleaching Agents. Den-Mat Corporation Role: Co-Investigator $29,000
August 1995–July 1997 P. gingivalis LPS: Serology and function USPHS Role: Principal Investigator $50,000
April 1991–March 1997 B gingivalis polysaccharides: structure and function USPHS Role: Principal Investigator $459,571
October 1995–January 1996 A dose ranging study to evaluate the local effects of various dosage regimens of beclomethasone dipropionate on recurrent apthous ulcers versus kenalog in orabase ALZA Corporation Role: Co-Investigator
December 1984–November 1989 Bacteroides gingivalis antigens and periodontal disease USPHS Role: Principal Investigator $350,000
Sahingur SE, Xia XJ, Schifferle RE. Oral Bacterial DNA Differ in Their Ability to Induce Inflammatory Responses in Human Monocytic Cell Lines. Journal of Periodontology. 2012.
Hajishengallis H, Martin M, Sojar H, Sharma A, Schifferle R, DeNardin E, Russell MW, Genco RJ. Dependence of Bacterial Protein Adhesion on Toll-Like Receptors for Proinflammatory Cytokine Induction. Clin Diagn Lab Immunol. 2002; 9.
Hajishengallis G, Martin M, Schifferle RE, Genco RJ. Counteracting Interactions Between Lipolysaccharide Molecules with Differential Activation of Toll-Like Receptors. Infection and Immunity. 2002; 70.
Sims, TJ, Lenmark A, Mancl LA, Schifferle RE, Page, RC, Persson, RG. Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.. J Clin Periodontol. 2002; 29.
Sims TJ, Schifferle RE, Ali RW, Skaug N, Page RC. Immunoglobulin G response of periodontitis patients to Porphyromonas gingivalis capsular carbohydrate and lipopolysaccharide antigens.. Oral Microbiol Immunol. 2001; 16(4).
Califano JV, Schifferle RE, Gunsolley JC, Best AM, Schenkein HA, Tew JG. Antibody reactive with Porphyromonas gingivalis serotypes K1-6 in adult and generalized early-onset periodontitis.. J Periodontol. 1999; 70(7).
Preshaw PM, Schifferle RE, Walters JD. Porphyromonas gingivalis lipopolysaccharide delays human polymorphonuclear leukocyte apoptosis in vitro.. J Periodontal Res. 1999; 34(4).
Choi J-I, Yoshimura F, Schifferle RE, Okuda K. IgG subclass-dependent recognition of Prophyromonas gingivalis antigens in the early-onset periodontitis.. J Korean Acad Periodontol.. 1999; 29.
Choi JI, Schifferle RE, Yoshimura F, Kim BW. Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes.. Infect Immun. 1998; 66(1).
Machtei EE, Hausmann E, Schmidt M, Grossi S, Dunford R, Schifferle RE, Munoz K, Davies G, Chandler J, Genco RJ. Radiographic and Clinical Response to Periodontal Therapy. J Periodontol. 1998; 69.
Schifferle RE, Promsudthi, A, Elvebak, L, Wrona, CT, Beanan JM. Isolation and characterization of K5 polysaccharide antigen of porphyromonas gingivalis strain E20-1. Int J Oral Biol. 1998; 23.
Grossi S, Zambon JJ, Machtei EE, Schifferle R, Andreana S, Genco RJ, Cummins D, Harrap G. Effects of Smoking on Healing After Mechanical Periodontal Therapy.. J Am Dent Assoc. 1997; 128(5).
Shibly O, Schifferle RE, Ciancio SG, Tarakji M, Mather ML. A clinical comparison of two electric toothbrush designs.. J Clin Periodontol. 1997; 24(4).
Schifferle RE, Shostad SA, Bayers-Thering MT, Dyer DW, Neiders M. Effect of protoporphyrin IX limitation on porphyromonas gingivalis.. J Endo. 1996; 22(7).
Schifferle RE. Maintenance of periodontal attachment with non-surgical periodontal therapy: A case report. Periodontal Insights. 1996; 3.
Pecora G, Andreana S, Covani U, De Leonardis D, Schifferle RE. New Directions in Surgical Endodontics: Immediate Implantation into an Extraction Socket. J Endod. 1996; 22(3).
Genco CA, Schifferle RE, Njoroge T, Forng RY, Cutler CW. Resistance of a Tn4351-generated polysaccharide mutant of Porphyromonas gingivalis to polymorphonuclear leukocyte killing.. Infect Immun. 1995; 63(2).
Schifferle RE, Chen PB, Davern LB, Aguirre A, Genco RJ, Levine MJ,. Modification of experimental Porphyromonas gingivalis murine infection by immunization with a polysaccharide-protein conjugate.. Oral Microbiol Immunol. 1993; 8(5).
Schifferle RE. Activation of serum complement by polysaccharide-containing antigens of Porphyromonas gingivalis. J. Periodont. Res. 1993; 28.
Wilson ME, Schifferle RE. Evidence that the serotype b antigenic determinant of Actinobacillus actinomycetemcomitans Y4 resides in the polysaccharide moiety of lipopolysaccharide.. Infect Immun. 1991; 59(4).
Schifferle RE, Reddy MS, Zambon JJ, Genco RJ, Levine MJ. Purification and immunochemical characterization of a polysaccharide antigen from Bacteroides gingivalis strain A7A1-28. J Immunol. 1989; 143.
Schifferle RE, Reddy MS, Zambon JJ, Genco RJ, Levine MJ. Characterization of a polysaccharide antigen from Bacteroides gingivalis.. J Immunol. 1989; 143.
Schifferle RE, Jennings HJ, Wessels MR, Katzenellenbogen E, Roy R, Kasper DL. Immunochemical characterization of the types la and Ib group B streptococcal polysaccharides. J Immunol. 1985; 135.
Merrick J, Schifferle RE, Zadarlik, K, Kano, K, Milgrom, F. Isolation and partial purification of the heterophile antigen of infectious mononucleosis from bovine erythrocytes.. J Supramol Struct. 1977; 6.
Schifferle RE, Mealy BL, Rose LF. Medical and Dental History. Periodontics: Medicine, Sugery and Implants. 2004.
Schifferle R. Bacterial polysaccharides as microbial virulence factors. Molecular pathogenesis of periodontal disease. 1994.
Abstracts:
Park Y, Parthasarthy K, Margarone III J, Schifferle R, Perinpanayagam H, Dziak R. Effects of EMD on Cytokine Production by Human PDL Fibroblasts. J Dent Res. 2007.
Hajishengallis, G, Sojar H, Sharma A, Martin, M, Schifferle R, DeNardin E, Genco RJ. Host Regulatory Interactions Between P. gingivalis Fimbriae and LPS. IADR Meeting in Chiba, Japan. J Dent Res. 2001.
Sims TJ, Lernmark LA, Mancl RE, Schifferle RE, Page RC, Persson RG. Serum autoantibody titers predict treatment outcome in IDDM periodontitis. J Dent Res. 2001; 80.
Schifferle RE, Beanan JM. Purification of a new polysaccharide serotype from Porphyromonas gingivalis.. J Dent Res. 2000; 79.
Sims TJ, Schifferle RE, Ali N, Skaug N, Page RC. IgG response to lipopolysaccharide and capsular antigens of Porphyromonas gingivalis in periodontitits.. J Dent Res. 2000; 79(speci).
Schifferle RE, Beanan JM. O-antigenic serotypes of P. gingivalis LPS.. J Dent Res. 1999; 78(speci).
Sims T, Schifferle RE, Ali RW, Skaug N, Page RC. Serum IgG reactivity of periodontitis patients to K antigens of Porphyromonsa gingivalis.. J Dent Res. 1999; 78(speci).
Preshaw PM, Schifferle RE, Walters JD. Porphyromonas gingivalis lipopolysaccharide delays apoptosis in vitro.. J Dent Res. 1999; 78(speci).
Califano JV, Schifferle RE, Gunsolley JC, Schenkein HA, Tew JG. Antibody reactive with Porphyromonsa gingivalis Serotypes K1-6 in adult and generalized early onset periodontitis.. J Dent Res. 1998; 77(speci).
Schifferle RE, Beanan JM, Leigh DF. Complement activation by Porphyromonas gingivalis polysaccharide and LPS.. J Dent Res. 1998; 77(speci).
Schifferle RE, Wieczkowski G, Ciancio SG, Andreana S, Mather M, Ho A. Clinical Evaluation of Whitening Toothpastes. J Dent Res. 1998; 77.
Shibly O, Ciancio SG, Schifferle RE, Tarakji M, Mather ML, Bessinger MA. Clinical comparison between two electric toothbrush designs.. J Periodontol. 1997; 68.
Choi J-I, Yoshimura F, Schifferle RE, O‘Kuda K. IgG subclass-dependent recognition of P. gingivalis antigens in early-onset periodontitis.. J Dent Res. 1997; 76(speci).
Schifferle RE, Leigh DF, Beanan JM. Purification of P. gingivalis polysaccharide and LPS.. J Dent Res. 1997; 76(speci).
Schifferle RE. O-Antigenic serotypes of P. gingivalis LPS. J Dent Res. 1996; 75.
Ciancio SG, Mather M, Bessinger M, Bush P, Schifferle RE. Pressure and motion requirements of a powered toothbrush. J Dent Res. 1996; 75(1416).
Schifferle RE, Promsudthi A, Wrona CT. Isolation of polysaccharide and lipopolysaccharide from P. gingivalis strains A7436 and E20-1.. J Dent Res. 1995; 74.
Grossi S, Zambon JJ, Machtei E, Schifferle RE, Andreana S, Cummins D, Harrap G, Genco RJ. Effect of Smoking on Healing After Mechanical Periodontal Treatment. J Dent Res. 1995; 74.
Schifferle RE, Wrona CT. Differential extraction of polysaccharide-containing antigens from P. gingivalis. J Dent Res. 1994; 73.
Nisengard R, Mikulski L, McDuffie D, McHenry K, Schifferle RE, Zambon JJ. Ligature-induced periodontitis following immunization with a B. macacae capsular function. J Dent Res. 1994; 73(2625).
Njoroge T, Cutler CW, Schifferle RE, Lassiter MO, Genco CA. Resistance of a Tn4351 capsule mutant of Porphyromonas gingivalis to PMN killing. J Dent Res. 1994; 73.
Schifferle RE, Wilson M, Levine MJ, Genco RJ. Serum complement activation by polysaccharide-containing Porphyromonas gingivalis antigens.. J Dent Res. 1993; 72.
Schifferle RE, Aguirre A, Genco RJ, Levine MJ. Polysaccharide-protein conjugate modifies experimental P. gingivalis murine infection.. J Dent Res. 1992; 71.
Schifferle RE, Chen PB, Davern LB, Aguirre A, Genco RJ. Immunogenicity of Polysaccharide from Bacteroides gingivalis. J Dent Res. 1990; 69.
Schifferle RE, Reddy MS, Levine MJ, Genco RJ. Immunochemical characterization of Bacteroides gingivalis polysaccharide.. J Dent Res. 1989; 68.
Reynolds HS, Van Winkelhoff AJ, Schifferle RE, Chen PB, Zambon JJ. Relationship of encapsulation of Bacteroides gingivalis to invasiveness. J Dent Res. 1989; 68(1171).
Schifferle RE, Levine MJ, Zambon JJ, Genco RJ. Characterization of polysaccharide antigens from Bacteroides gingivalis.. J Dent Res. 1988; 67(1019).
Schifferle RE. Immunochemical studies of a capsular polysaccharide. J Periodontol. 1986; 57.
Schifferle RE, Millar SJ, Levine MJ, Zambon JJ, Genco RJ. Isolation of a high-molecular weight component of Bacteroides gingivalis.. J Dent Res. 1986; 65.
Chen P, Dickenson DP, Millar RE, Schifferle RE, Levine MJ. Characterization of Bacteroides gingivalis antigens using monoclonal antibodies.. J Dent Res. 1986; 65.
Umemoto T, Bonta Y, Schifferle RE, Zambon JJ, Genco RJ. Variation in Colony Morphology Correlates with Firmbriation in A. actinomycetemcomitans. J Dent Res. 1986; 35(314).
Schifferle RE, Zambon JJ, Yoshimura F, Genco RJ. Immunological Response to Fimbriae From Bacteroides gingivalis. J Dent Res. 1985; 64(201).
Zambon JJ, Schifferle RE, Reynolds HS, Genco RJ. Serological Studies of Oral Bacteroides intermedius. J Dent Res. 1985; 64(534).
Schifferle RE, Bahl V, Tabak LA, Levine MJ. Crossed immunoelectrophoresis of human parotid and submandibular-sublingual saliva.. J Dent Res. 1981; 60.
American Association for the Advancement of Science (1982–2002)
American Academy of Periodontology (1981–2019)
American Association for Dental Research (1981–2019)
International Association for Dental Research (1981–2019)
American Dental Association (1978–2019)
American Dental Assocaition (1978–2016)
Presentations:
"Crown Lengthening and Local Antimicrobial Therapy" Inservice Lecture, School of Dental Medicine, Restorative Dentistry (2105)
"Nutrition and Dental Health" Summer Gateway Program for Native American students, School of Dental Medicine (2019)
"Nutrition in Dentistry" University at Buffalo (2018)
"Nutrition and Dental Disease" WNY Dental Assistant Association (2016)
"Periodontal Therapy: An Update" Erie County Medical Center, Erie County Medical Center, Dental Residents (2013)
"Relationship Between Periodontal Disease and Systemic Health" Chinese Stomatological Association (2012)
"Managing the Periodontal Patient...Tales & Tidbits" University at Buffalo - CE (2010)
"Screening of Patients in a Dental Setting for Undiagnosed Diabetes and Pre-Diabetes: A Groundbreaking Study" Delta Dental of Rhode Island Study Initiation, Delta Dental of Rhode Island (2010)
"Periodontal Update - 3 hr" C.E. SUNY at Buffalo (2009)
"Contemporary Periodontics" Three-hour lecture, SUNY at Buffalo, SUNY at Buffalo (2002)
"Redefining Periodontal Disease Management" One hour lecture, SUNY at Buffalo, SUNY at Buffalo (2000)
"Controlled Release Devices in Collagenolytic Enzyme Suppression" Erie Community College Dental Hygiene Program, Erie Community College Dental Hygiene Program (1999)
"Periodontal Disease and Antimicrobials" Erie Community College Dental Hygiene Program, Erie Community College Dental Hygiene Program (1999)
"Advances in Dental Hygiene" Three-hour lecture, SUNY at Buffalo, SUNY at Buffalo (1999)
"Periodontal Therapy Overview" 9th Annual I.L. Kerr memorial Lecture (1998)
"Dental Pharmacology and Actisite Fiber Therapy" Erie Community College Dental Hygiene Program, Erie Community College Dental Hygiene Program (1998)
"Advanced Program in Dental Hygiene" Three-hour lecture, SUNY at Buffalo, SUNY at Buffalo (1998)
"A Concise Review of Current Periodontal Therapy" Course Director, 1.5 hour lecture, SUNY at Buffalo, SUNY at Buffalo (1997)
"Advances in Dental Hygiene" Three hour lecture, SUNY at Buffalo, SUNY at Buffalo (1997)
"Dental Pharmacology and Actisite Fiber Therapy" Erie Community College Dental Hygiene Program, Erie Community College Dental Hygiene Program (1997)
"Current Concepts in Periodontal Therapy" 5 hour of lecture and 3-hour of clinical instruction for Italian dental hygienists, SUNY at Buffalo, SUNY at Buffalo (1996)
"Bacterial Aspects of Periodontal Diseases" Annual Symposium for Dental Hygienists (1996)