Praveen R. Arany
Praveen R. Arany
Assistant Professor
Specialty/Research Focus
Oral Biology; Oral Pathology
Professional Summary:
My major interest is focused on clinical translation of biological mechanisms for wound healing and tissue regeneration. Our group uses cell-molecular biology, biomaterials and biomedical technologies to explore biological regulation and use this information for therapeutics to control favorable clinical outcomes.
Education and Training:
- Postdoctoral Fellow, Bioengineering, Harvard School of Engineering and Applied Sciences (2012)
- PhD, Biological Sciences in Dental Medicine, Harvard University (2011)
- MDent, Oral Biology, Harvard University (2011)
- Residency, Oral and Maxillofacial Pathology, Harvard School of Dental Medicine (2011)
- Cert, Clinical translational research, Harvard Medical School (2011)
- Cert, Clinical research curriculum, National Institutes of Health (2007)
- Postdoctoral Fellow, Cancer biology, Radiation biology, National Cancer Institute, National Institutes of Health (2006)
- Postdoctoral Fellow, Growth factor biology, Indian Institutes of Sciences (2003)
- MDent, Oral and Maxillofacial Pathology, Rajiv Gandhi University of Health Sciences (2001)
- DDS, General Dental surgery, Dharwad University (1999)
Employment:
- Assitant Professor, Tenure-Track, Oral Biology, School of Dental Medicine, University at Buffalo (2015-present)
- Assistant Clinical Investigator, Oral and Pharyngeal Cancer Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health (2012–2015)
Awards and Honors:
- Horace Furumoto Young Investigator Award (2016)
- Best Paper in Laser Annals (2014)
- Eugene Siedner Scholar, Academy of Laser Dentistry (2011)
- Pulp Biology & Regeneration Award, American Academy of Dental Research (2011)
- Best review paper, Oral Diseases journal (2011)
- Wound Biotechnology Foundation Award, Wound Healing Society (2009)
- Young investigators Award, Wound Healing Society (2007)
- Harvard Presidential Scholar (2007)
- NIH Merit Award (Intramural) (2006)
- NCI Director’s Innovation Award - Young Investigator (2006)
- Best Paper award, Indian Academy of Oral Pathologists (2001)
- Best Poster award, Indian Academy of Oral Pathologists (2001)
- Best Poster award, Indian Academy of Oral Pathologists (2000)
Research Expertise:
- Low dose Biophotonics Therapy: Expert in light therapy termed Photobimodulation
- Stem cells in regenerative medicine: Approaches to direct differentiation of stem cells to promote tissue healing and regeneration
- TGF beta Biology: TGF beta signaling and roles in health and disease, especially in wound healing and stem cells biology
Grants and Sponsored Research:
- January 2019–January 2021
Bluesky University at BUffalo
University at Buffalo
Role: Principal Investigator
$30,000 - August 2020–November 2020
Goldwave Biotechnology
Role: Principal Investigator
$30,000 - January 2018–July 2020
SBIR Phase II NIH/NIDCR
NIDCR / NIH
Role: Co-Principal Investigator
$658,738 - October 2016–November 2017
Neurocognitive, electrophysiological and MRI changes associated with low level laser therapy (photobiomodulation) in the treatment of Traumatic Brain Injury: A pilot study
American Society for Laser Medicine and Surgery
Role: Principal Investigator
$68,000 - December 2016–July 2017
Philips Research Labs
Philips Research
Role: Principal Investigator
$13,000 - July 2016–June 2017
American Society of Lasers in Surgery and Medicine
American Society of Lasers in Surgery and Medicine
Role: Principal Investigator
$78,000
Patents:
- In situ antigen generating cancer vaccine Use of biomaterials based cancer vaccines for therapy (2012)
- Laser-actuated nanoparticles Use of albumin based nanoparticles for therapeutic payload delivery that can be activated by laser illumination for controlled spatial and temporal delivery (2012)
- Laser dental treatment systems Use of low power laser systems for photobiomodulation therapy (2012)
- Temporally and spatially restricted morphogen fields Use of biomaterials based scaffold systems to generate development-like morphogen fields to direct tissue differentiation for regenerative applications (2011)
Journal Articles:
- Khan I, Tang E, Arany P. Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress. Sci Rep. 2015; 5.
- Palmier NR, Leme AFP, De Rossi T, Telles GP, Morais-Faria K, Kowalski LP, Marta GN, Brandão TB, Arany PR, Migliorati CA, Santos-Silva AR, Prado-Ribeiro AC. Salivary alpha-1-antitrypsin and macrophage migration inhibitory factor may be potential prognostic biomarkers for oncologic treatment-induced severe oral mucositis. Support Care Cancer. 2020.
- Tam M, Arany PR, Robijns J, Vasconcelos R, Corby P, Hu K. Photobiomodulation Therapy to Mitigate Radiation Fibrosis Syndrome. Photobiomodul Photomed Laser Surg. 2020; 38(6).
- Arany PR. Enhancing Skin Grafts with Primed Gingival Mesenchymal Stromal Cells. J Invest Dermatol. 2020; 140(3).
- Mane DR, Rahman SU, Desai KM, Kale AD, Bhat KG, Arany PR. Roles of the matricellular protein Tenascin-C in T-lymphocyte trafficking and etiopathogenesis of Oral Lichen Planus. Arch Oral Biol. 2020; 110.
- Taha K, Conley RS, Arany P, Warunek S, Al-Jewair T. Effects of mechanical vibrations on maxillary canine retraction and perceived pain: A pilot, single-center randomized controlled clinical trial. Odontology. 2020.
- Zadik Y, Arany PR, Fregnani ER, Bossi P, Antunes HS, Bensadoun RJ, Gueiros LA, Majorana A, Nair RG, Ranna V, Tissing WJE, Vaddi A, Lubart R, Migliorati CA, Lalla RV, Cheng KKF, Elad S. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019; 27(10).
- Cronshaw M, Parker S, Arany P, Arany PR. Feeling the Heat: Evolutionary and Microbial Basis for the Analgesic Mechanisms of Photobiomodulation Therapy. Photobiomodul Photomed Laser Surg. 2019; 37(9).
- Hosseinpour S, Fekrazad R, Arany PR, Ye Q. Molecular impacts of photobiomodulation on bone regeneration: AÂ systematic review. Prog Biophys Mol Biol. 2019.
- Rahman SU, Nagrath M, Ponnusamy S, Arany PR. Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering. Materials (Basel). 2018; 11(8).
- Brandão TB, Morais-Faria K, Ribeiro ACP, Rivera C, Salvajoli JV, Lopes MA, Epstein JB, Arany PR, de Castro G, Migliorati CA, Santos-Silva AR. Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. Support Care Cancer. 2018; 26(7).
- Rahman SU, Mosca RC, Govindool Reddy S, Nunez SC, Andreana S, Mang TS, Arany PR. Learning from clinical phenotypes: Low-dose biophotonics therapies in oral diseases. Oral Dis. 2018; 24(1-2).
- Epstein JB, Raber-Durlacher JE, Huysmans MC, Schoordijk MCE, Cheng JE, Bensadoun RJ, Arany PR. Photobiomodulation Therapy Alleviates Tissue Fibroses Associated with Chronic Graft-Versus-Host Disease: Two Case Reports and Putative Anti-Fibrotic Roles of TGF-β. Photomed Laser Surg. 2018; 36(2).
- Fekrazad R, Sarrafzadeh A, Kalhori KAM, Khan I, Arany PR, Giubellino A. Improved Wound Remodeling Correlates with Modulated TGF-beta Expression in Skin Diabetic Wounds Following Combined Red and Infrared Photobiomodulation Treatments. Photochem Photobiol. 2018; 94(4).
- Arany PR. The Skinny on Fats in Wound Healing. J Invest Dermatol. 2018; 138(9).
- Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017; 114(41).
- Tang E, Khan I, Andreana S, Arany PR. Laser-activated transforming growth factor-β1 induces human β-defensin 2: implications for laser therapies for periodontitis and peri-implantitis. J Periodontal Res. 2017; 52(3).
- Rahman SU, Arany PR. 3D bioprinting: prostheses-restorations…now, tissues and organ systems! Oral Dis. 2017; 23(4).
- Engel KW, Khan I, Arany PR. Cell lineage responses to photobiomodulation therapy. J Biophotonics. 2016; 9(11-12).
- Arany PR, Wilder-Smith P. Special issue on lasers in dentistry. Lasers Surg Med. 2016; 48(10).
- Arany PR. Special Issue on Stem Cells and Photobiomodulation Therapy. Photomed Laser Surg. 2016; 34(11).
- Arany PR. Photobiomodulation Therapy: Communicating with Stem Cells for Regeneration? Photomed Laser Surg. 2016; 34(11).
- Arany PR. Craniofacial Wound Healing with Photobiomodulation Therapy: New Insights and Current Challenges. J Dent Res. 2016; 95(9).
- Khan I, Arany PR. Dosimetry for photobiomodulation therapy: response to Sommers et al. Ann Transl Med. 2016; 4(10).
- Hall BE, Zhang L, Sun ZJ, Utreras E, Prochazkova M, Cho A, Terse A, Arany P, Dolan JC, Schmidt BL, Kulkarni AB, Arany PR. Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis. J Dent Res. 2016; 95(2).
- Huang GX, Arany P, Mooney DJ. Modeling and Validation of Multilayer Poly(Lactide-Co-Glycolide) Scaffolds for In Vitro Directed Differentiation of Juxtaposed Cartilage and Bone. Tissue Eng Part A. 2015; 21(15-16).
- Fekrazad R, Mirmoezzi A, Kalhori KA, Arany P. The effect of red, green and blue lasers on healing of oral wounds in diabetic rats. J Photochem Photobiol B. 2015; 148.
- Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D. Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med. 2014; 6(238).
- Tang E, Arany P. Photobiomodulation and implants: implications for dentistry. J Periodontal Implant Sci. 2013; 43(6).
- Cho A, Haruyama N, Hall B, Danton MJ, Zhang L, Arany P, Mooney DJ, Harichane Y, Goldberg M, Gibson CW, Kulkarni AB, Arany PR. TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One. 2013; 8(11).
- Hall BE, Wankhade UD, Konkel JE, Cherukuri K, Nagineni CN, Flanders KC, Arany PR, Chen W, Rane SG, Kulkarni AB. Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance. J Biol Chem. 2013; 288(44).
- Cho A, Haruyama N, Hall B, Danton MJ, Zhang L, Arany P, Mooney DJ, Harichane Y, Goldberg M, Gibson CW, Kulkarni AB. TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One. 2013; 8(11).
- Bencherif SA, Sands RW, Bhatta D, Arany P, Verbeke CS, Edwards DA, Mooney DJ. Injectable preformed scaffolds with shape-memory properties. Proc Natl Acad Sci U S A. 2012; 109(48).
Service Activities:
- School of Dental Medicine Ad Hoc Committee; Delegate (2015)
- Laser Safety Committee; Member (2015–present)
- Students Research and Honors Committee; Member (2015–present)