Patricia I. Diaz
Patricia I. Diaz
Professor of Empire Innovation, Director UB Microbiome Center
Specialty/Research Focus
Microbiology; Oral Biology; Periodontics
Professional Summary:
My research program focuses on the oral microbiome. My laboratory uses clinical studies, genomics, computational biology and model systems to study the processes that lead to dysbiosis of the oral microbiome. Our goal is to understand community dynamics and develop tools to manipulate the microbiome thereby interfering with disease development. We are particularly interested in understanding the significance of the microbiome as a mediator of susceptibility to oral comorbidities of cancer treatment and as an essential trigger in periodontal disease. We also investigate the potential for the salivary microbiome to serve as a biomarker for oral and systemic conditions.
Education and Training:
- MS, University of North Carolina at Chapel Hill (2008)
- Residency, University of North Carolina at Chapel Hill (2008)
- PhD, The University of Adelaide (2003)
- DDS, CES University (1996)
Employment:
- Professor of Empire Innovation, Oral Biology, University at Buffalo, School of Dental Medicine (2020-present)
- Associate Professor, Oral Health and Diagnostic Sciences, University of Connecticut Health Center, School of Dental Medicine (2015–2020)
- Assistant Professor, Oral Health and Diagnostic Sciences, University of Connecticut Health Center, School of Dental Medicine (2008–2015)
- Post Doctoral Fellow, Laboratory of Dr. Paul Kolenbrander, NIDCR, NIH (2003–2005)
Research Expertise:
- Microbiology
- Periodontology
Grants and Sponsored Research:
- July 2020–June 2025
Treatment of Periodontitis by Homing M2 Macrophages
NIH
Role: Co-Investigator - August 2019–May 2021
HBD-3: A novel factor orchestrating microbial persistence in suspicious oral lesions
NIH
Role: Co-Investigator
Journal Articles:
- Hong BY, Hoare A, Cardenas A, Dupuy AK, Choquette L, Salner AL, Schauer PK, Hegde U, Peterson DE, Dongari-Bagtzoglou A, Strausbaugh LD, Diaz PI. The Salivary Mycobiome Contains 2 Ecologically Distinct Mycotypes. J Dent Res. 2020; 99(6).
- Diaz PI, Valm AM. Microbial Interactions in Oral Communities Mediate Emergent Biofilm Properties. J Dent Res. 2020; 99(1).
- Curtis MA, Diaz PI, Van Dyke TE. The role of the microbiota in periodontal disease. Periodontol 2000. 2020; 83(1).
- Diaz PI, Hong BY, Dupuy AK, Choquette L, Thompson A, Salner AL, Schauer PK, Hegde U, Burleson JA, Strausbaugh LD, Peterson DE, Dongari-Bagtzoglou A. Integrated Analysis of Clinical and Microbiome Risk Factors Associated with the Development of Oral Candidiasis during Cancer Chemotherapy. J Fungi (Basel). 2019; 5(2).
- Hong BY, Sobue T, Choquette L, Dupuy AK, Thompson A, Burleson JA, Salner AL, Schauer PK, Joshi P, Fox E, Shin DG, Weinstock GM, Strausbaugh LD, Dongari-Bagtzoglou A, Peterson DE, Diaz PI. Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis. Microbiome. 2019; 7(1).
- Bertolini M, Ranjan A, Thompson A, Diaz PI, Sobue T, Maas K, Dongari-Bagtzoglou A. Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection. PLoS Pathog. 2019; 15(4).
- Dutzan N, Kajikawa T, Abusleme L, Greenwell-Wild T, Zuazo CE, Ikeuchi T, Brenchley L, Abe T, Hurabielle C, Martin D, Morell RJ, Freeman AF, Lazarevic V, Trinchieri G, Diaz PI, Holland SM, Belkaid Y, Hajishengallis G, Moutsopoulos NM. A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans. Sci Transl Med. 2018; 10(463).
- Abusleme L, Diaz PI, Freeman AF, Greenwell-Wild T, Brenchley L, Desai JV, Ng WI, Holland SM, Lionakis MS, Segre JA, Kong HH, Moutsopoulos NM. Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis. JCI Insight. 2018; 3(17).
- Morales A, Gandolfo A, Bravo J, Carvajal P, Silva N, Godoy C, Garcia-Sesnich J, Hoare A, Diaz P, Gamonal J, Diaz PI. Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up. J Appl Oral Sci. 2018; 26.
- Sobue T, Bertolini M, Thompson A, Peterson DE, Diaz PI, Dongari-Bagtzoglou A. Chemotherapy-induced oral mucositis and associated infections in a novel organotypic model. Mol Oral Microbiol. 2018; 33(3).
- Van Dyke TE, Diaz PI, Moutsopoulos N, Alekseyenko AV, Ioannidou E. Task Force on Design and Analysis in Oral Health Research: Host-Microbiome Interactions in Dysbiosis. JDR Clin Trans Res. 2018; 3(1).
- Abusleme L, Hong BY, Hoare A, Konkel JE, Diaz PI, Moutsopoulos NM. Oral Microbiome Characterization in Murine Models. Bio Protoc. 2017; 7(24).
- Hoare A, Marsh PD, Diaz PI. Ecological Therapeutic Opportunities for Oral Diseases. Microbiol Spectr. 2017; 5(4).
- Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DME, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM. On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier. Immunity. 2017; 46(1).
- Schincaglia GP, Hong BY, Rosania A, Barasz J, Thompson A, Sobue T, Panagakos F, Burleson JA, Dongari-Bagtzoglou A, Diaz PI. Clinical, Immune, and Microbiome Traits of Gingivitis and Peri-implant Mucositis. J Dent Res. 2017; 96(1).
- Diaz PI, Hong BY, Dupuy AK, Strausbaugh LD. Mining the oral mycobiome: Methods, components, and meaning. Virulence. 2017; 8(3).
- Morales A, Carvajal P, Silva N, Hernandez M, Godoy C, Rodriguez G, Cabello R, Garcia-Sesnich J, Hoare A, Diaz PI, Gamonal J. Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up. J Periodontol. 2016; 87(8).
- Diaz PI, Hoare A, Hong BY. Subgingival Microbiome Shifts and Community Dynamics in Periodontal Diseases. J Calif Dent Assoc. 2016; 44(7).
- Sobue T, Diaz P, Xu H, Bertolini M, Dongari-Bagtzoglou A, Diaz PI. Experimental Models of C. albicans-Streptococcal Co-infection. Methods Mol Biol. 2016; 1356.
- Araújo MV, Hong BY, Fava PL, Khan S, Burleson JA, Fares G, Samson W, Strausbaugh LD, Diaz PI, Ioannidou E. End stage renal disease as a modifier of the periodontal microbiome. BMC Nephrol. 2015; 16.
- Hong BY, Furtado Araujo MV, Strausbaugh LD, Terzi E, Ioannidou E, Diaz PI. Microbiome profiles in periodontitis in relation to host and disease characteristics. PLoS One. 2015; 10(5).
- Diaz PI, Strausbaugh LD, Dongari-Bagtzoglou A. Fungal-bacterial interactions and their relevance to oral health: linking the clinic and the bench. Front Cell Infect Microbiol. 2014; 4.
- Abusleme L, Hong BY, Dupuy AK, Strausbaugh LD, Diaz PI. Influence of DNA extraction on oral microbial profiles obtained via 16S rRNA gene sequencing. J Oral Microbiol. 2014; 6.
- Dupuy AK, David MS, Li L, Heider TN, Peterson JD, Montano EA, Dongari-Bagtzoglou A, Diaz PI, Strausbaugh LD. Redefining the human oral mycobiome with improved practices in amplicon-based taxonomy: discovery of Malassezia as a prominent commensal. PLoS One. 2014; 9(3).
- Xu H, Sobue T, Thompson A, Xie Z, Poon K, Ricker A, Cervantes J, Diaz PI, Dongari-Bagtzoglou A. Streptococcal co-infection augments Candida pathogenicity by amplifying the mucosal inflammatory response. Cell Microbiol. 2014; 16(2).
- Diaz PI, Hong BY, Frias-Lopez J, Dupuy AK, Angeloni M, Abusleme L, Terzi E, Ioannidou E, Strausbaugh LD, Dongari-Bagtzoglou A. Transplantation-associated long-term immunosuppression promotes oral colonization by potentially opportunistic pathogens without impacting other members of the salivary bacteriome. Clin Vaccine Immunol. 2013; 20(6).
- Abusleme L, Dupuy AK, Dutzan N, Silva N, Burleson JA, Strausbaugh LD, Gamonal J, Diaz PI. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 2013; 7(5).
- BiyikoÄŸlu B, Ricker A, Diaz PI. Strain-specific colonization patterns and serum modulation of multi-species oral biofilm development. Anaerobe. 2012; 18(4).
- Diaz PI, Dupuy AK, Abusleme L, Reese B, Obergfell C, Choquette L, Dongari-Bagtzoglou A, Peterson DE, Terzi E, Strausbaugh LD. Using high throughput sequencing to explore the biodiversity in oral bacterial communities. Mol Oral Microbiol. 2012; 27(3).
- Diaz PI, Xie Z, Sobue T, Thompson A, Biyikoglu B, Ricker A, Ikonomou L, Dongari-Bagtzoglou A. Synergistic interaction between Candida albicans and commensal oral streptococci in a novel in vitro mucosal model. Infect Immun. 2012; 80(2).
- Diaz PI. Microbial diversity and interactions in subgingival biofilm communities. Front Oral Biol. 2011; 15.
- Arce RM, Diaz PI, Barros SP, Galloway P, Bobetsis Y, Threadgill D, Offenbacher S. Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures. J Reprod Immunol. 2010; 84(2).
- Dongari-Bagtzoglou A, Kashleva H, Dwivedi P, Diaz P, Vasilakos J, Diaz PI. Characterization of mucosal Candida albicans biofilms. PLoS One. 2009; 4(11).
- Macedo GV, Diaz PI, De O Fernandes CA, Ritter AV. Reattachment of anterior teeth fragments: a conservative approach. J Esthet Restor Dent. 2008; 20(1).
- Palmer RJ, Diaz PI, Kolenbrander PE. Rapid succession within the Veillonella population of a developing human oral biofilm in situ. J Bacteriol. 2006; 188(11).
- Diaz PI, Chalmers NI, Rickard AH, Kong C, Milburn CL, Palmer RJ, Kolenbrander PE. Molecular characterization of subject-specific oral microflora during initial colonization of enamel. Appl Environ Microbiol. 2006; 72(4).
- Diaz PI, Slakeski N, Reynolds EC, Morona R, Rogers AH, Kolenbrander PE. Role of oxyR in the oral anaerobe Porphyromonas gingivalis. J Bacteriol. 2006; 188(7).
- Kolenbrander PE, Palmer RJ, Rickard AH, Jakubovics NS, Chalmers NI, Diaz PI. Bacterial interactions and successions during plaque development. Periodontol 2000. 2006; 42.
- Kolenbrander PE, Egland PG, Diaz PI, Palmer RJ. Genome-genome interactions: bacterial communities in initial dental plaque. Trends Microbiol. 2005; 13(1).
- Diaz PI, Zilm PS, Wasinger V, Corthals GL, Rogers AH. Studies on NADH oxidase and alkyl hydroperoxide reductase produced by Porphyromonas gingivalis. Oral Microbiol Immunol. 2004; 19(3).
- Diaz PI, Rogers AH. The effect of oxygen on the growth and physiology of Porphyromonas gingivalis. Oral Microbiol Immunol. 2004; 19(2).
- Diaz PI, Zilm PS, Rogers AH. Fusobacterium nucleatum supports the growth of Porphyromonas gingivalis in oxygenated and carbon-dioxide-depleted environments. Microbiology. 2002; 148(Pt 2).
- Diaz PI, Zilm PS, Rogers AH. The response to oxidative stress of Fusobacterium nucleatum grown in continuous culture. FEMS Microbiol Lett. 2000; 187(1).