Postdoctoral Fellow, Microbiology immunology, University of Toronto (2013)
Postdoctoral Fellow, Microbiology cell biology, University of Toronto (2012)
PhD, Veterinary Science, University of Queensland (2009)
BS, Biological Sciences, University of Calgary (1998)
Employment:
Associate Professor, Oral Biology, University at Buffalo (2020-present)
Assistant Professor, Oral Biology, University at Buffalo (2013–2019)
Post Doctoral Fellow, Matrix Dynamics Group, University of Toronto, Faculty of Dentistry, Canada (2012–2013)
Post Doctoral Fellow, Oral Microbiology, University of Toronto, Faculty of Dentistry, Canada (2008–2012)
Research Technician, Microbiology and Infectious Diseases, University of Calgary, Canada (1999–2005)
Awards and Honors:
UUP Individual Development Award (2017)
Canadian Institute of Health Research Postdoctoral Fellowship (2012)
Canadian Institute of Health Research, Institute of Musculoskeletal Health and Arthritis Travel Award (2011)
Canadian Institute of Health Research, Institute of Musculoskeletal Health and Arthritis Travel Award (2010)
Rural Industries Research and Development Corporation of Australia Travel Grant (2008)
Endeavour International Postgraduate Research Scholarship (2005)
University of Queensland International Living Allowance Scholarship (2005)
Research Expertise:
Host-pathogen interactions
Innate immunology
Microbiology
Grants and Sponsored Research:
December 2019–November 2024 A role for immune cell plasticity in commensal survival and escalation of inflammation NIH/NIDCR Role: Co-Investigator $1,952,242
September 2018–August 2023 The role of oral spirochete virulence factors in the impairment of neutrophil response NIH Role: Principal Investigator $1,894,065
April 2017–March 2018 Modification of healing abutment surface with strontium containing alginate gel to promote gingival fibroblast function International Congress of Oral Implantalogists Role: Principal Investigator $24,968
January 2017–January 2018 Investigation of global lipid analysis and metabolism in neutrophil function and chronic disease UB IMPACT Role: Principal Investigator $31,000
December 2016–December 2017 Mechanisms of neutrophil impairment by Treponema denticola NIDCR Role: Principal Investigator $19,000
January 2015–December 2016 Mechanisms of neutrophil impairment by Treponema denticola NIDCR Role: Principal Investigator $238,876
Fernandes G, Visser M, Renné WG, Sabatini C.. Esterase Inhibition and Copper Release from Copper Iodide Adhesive Matrices.. J Dent Res. 2017.
Alghanem, A. A., G. Fernandes, M. Visser, R. Dziak, W.G. Renne and C. Sabatini. Biocompatibility and bond degradation of poly-acrylic acid coated copper iodide-adhesives. Dental Materials. 2017; 33(9).
Mair YH, Jhamb T, Visser MB, Aguirre A, Kramer JM. Sera and salivary matrix metalloproteinases are elevated in patients with vesiculoerosive disease: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 121(5).
Lakschevitz FS, Visser MB, Sun C, Glogauer M. Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation. Cell Mol Immunol. 2015; 12(1).
Chambers CE, Lutter EI , Visser MB, Law PP, Sokol PA. Identification of potential CepR regulated genes using a cep box motif-based search of the Burkholderia cenocepacia genome. BMC Microbiol. 2006; 6(104).
American Association for Dental research (2013–present)
Canadian Association for Dental Research (2013–2014)
International Association for Dental Research (2013–present)
American Society for Microbiology (2010–present)
American Society for Cell Biology (2009–present)
Presentations:
"Lipid Metabolite Regulation and Impairment of neutrophil chemotaxis by Treponema denticola" UB Honors Research Student Symposium (2017)
"OncostatinM induction from Immune cells by Treponema denticola with implications for matrix-metalloprotease production" Buffalo Conference on Microbial Pathogenesis (2017)
"Outer membrane vesicles and variation in the outer membrane sheath protein of Treponema denticola alter neutrophil function" Buffalo Conference on Microbial Pathogenesis (2017)
"Lipid Metabolite Regulation and Impairment of neutrophil chemotaxis by Treponema denticola." UB Celebration of Student Academic Excellence. (2017)
"Oral Spirochetes and neutrophils: surviving under the radar in the oral cavity" Invited seminar Series, Oklahoma State University (2017)
"Characterizing the Treponema denticola Major outer sheath protein region responsible for neutrophil impairment" UB School of Dental Medicine Research Day (2017)
"Major Outer Sheath-Like Proteins of Oral Spirochetes Impair Neutrophil Function." International Association of Dental Research Annual Meeting, IADR (2017)
"The effect of oncostatinM in matrix metalloprotease activation in gingival fibroblasts" UB School of Dental Medicine Research Day (2017)
"Insights into Oral spirochete neutrophil interactions" 16th Annual Mark Wilson Conference (2017)
"Treponema denticola impairment of neutrophil chemotaxis" Gordon research conference on Directed Cell Migration (2017)
"Biological active regions of the Treponema denticola outer sheath protein (Msp) modulate neutrophil function" Buffalo Conference on Microbial Pathogenesis, The Witebsky Center for Microbial Pathogenesis and Immunology (2016)
"Oncostatin M induction from immune cells by Treponema denticola" American Association for Dental Research General Session and Exhibition (2016)
"Treponema denticola induction of oncostatin M from immune cells" Gordon Research Conference on Biology of Spirochetes (2016)
"Major outer sheath (Msp)-like proteins of oral spirochetes impair neutrophil chemotaxis" Buffalo Conference on Microbial Pathogenesis, The Witebsky Center for Microbial Pathogenesis and Immunology (2015)
"PREVENTION OF DRY SOCKET USING DOXYCYCLINE/LOCAL ANAESTHETIC IN A GELFOAM SCAFFOLD" Buffalo Conference on Microbial Pathogenesis, The Witebsky Center for Microbial Pathogenesis and Immunology (2015)
"The effect of Treponema denticola on oncostatinM expression and production from neutrophils" UB dental student research day, University at Buffalo (2015)
"Oral Spirochetes…. Surviving the Immune system" AADR Buffalo Section Lunch and Learn, University at Buffalo, AADR Buffalo Section (2014)
"Neutrophil mediated transcriptional responses to Treponema denticola exposure." Gordon Research Conference Biology of Spirochetes (2014)
"Development of oral microbe-induced periodontitis and fluorescent Treponema denticola." U of T Faculty of Dentistry Annual Research Day., University of Toronto (2013)
"Neutrophil chemotaxis regulatory pathways perturbed by the major outer sheath protein of Treponema denticola" SickKids-McMaster University-University of Toronto Research Day (2013)
"Oral spirochetes and innate immune interactions in periodontal disease" Invited Seminar Series, University of Manitoba, Oral Biology (2013)
"Oral spirochetes and innate immune interactions in periodontal disease" Invited Seminar Series, University of Louisville, Center for Oral Health and Systemic Disease (2013)
"Oral spirochetes and innate immune interactions in periodontal disease" Invited seminar series, University at Buffalo, Oral Biology (2012)
"Mechanisms of innate immunity evasion by oral spirochetes in periodontal disease" Invited seminar series, University of the Pacific, Biomedical Sciences (2012)
"Treponema denticola Msp activates lipid phosphatase and actin-uncapping, inhibits PMN-chemotaxis." International Association for Dental Research General Session, International Association for Dental Research (2012)
"The involvement of lipid phosphatase activation in perturbation of neutrophil functions by the major outer sheath protein of Treponema denticola" Gordon Research Conference on Biology of Spirochetes, Gordon Research Conferences (2012)
"Development of oral microbe-induced periodontitis mouse model and fluorescent Treponema denticola for future investigations using intravital microscopy." Farncombe/Toronto Research Day (2011)
"The major outer sheath protein of Treponema denticola induces actin filament assembly by a PIP-2 dependent uncapping mechanism in fibroblasts" U of T Infectious Diseases/Microbiology Research Day, University of Toronto (2011)
"The major outer sheath protein of Treponema denticola induces actin filament assembly by a PIP-2 dependent uncapping mechanism in fibroblasts" ASM General meeting, American Society of Microbiology (2011)
"The major outer sheath protein of Treponema denticola induces actin filament assembly by a PIP-2 dependent uncapping mechanism in fibroblasts" UofT Faculty of Dentistry Research Day, University of Toronto, Faculty of Dentistry (2011)
"Impact of Treponema denticola major outer sheath protein (Msp) on small GTPase associated signaling pathways in fibroblasts" Canadian Connective Tissue Conference, Canadian Connective Tissue Society (2010)
"Microbiology and cell biology of spirochete - host cell interactions" Invited Seminar Series, University of Toronto, Oral Microbiology (2010)
"Treponema denticola major outer sheath protein (Msp) impacts small GTPase signalling pathways differently in fibroblasts and neutrophils" University of Toronto Faculty of Dentistry Research Day, University of Toronto (2010)
"Treponema denticola major outer sheath protein (Msp) inhibits Akt activation without affecting the mitogen-activated protein kinase (MAPK) pathway in neutrophils" Gordon Research Conference on Biology of Spirochetes, Gordon Research Conferences (2010)
"Leukocyte infiltration and the role of IL-6 during the development of oligofructose induced laminitis." AAEP Equine Laminitis Research Workshop, American Association of Equine Practitioners (2009)
"Temporal changes in basement membrane proteolysis and protease expression during laminitis development" AAEP Equine Laminitis Research Workshop, American Association of Equine Practitioners (2009)
"Investigation of the signaling pathways involved in the perturbation of neutrophil chemotaxis and actin dynamics by Treponema denticola" University of Toronto Infectious Diseases/Microbiology Research Day, University of Toronto (2009)
"Temporal changes in the expression of basement membrane components and matrix metalloproteases during the development of equine laminitis." Gordon Research Conference on Basement Membranes, Gordon Research Conferences (2008)
"Degradation of basement membrane components occur prior to changes in the expression of matrix metalloproteases during the development of equine laminitis." Australian Equine Science Symposium (2008)
"Distribution of Laminin 5 in equine tissues and a potential linking factor in laminitis" Faculty of Natural resources, Agriculture and Veterinary Science Research Conference, University of Queensland (2005)
"A Sensitive Luminescence Reporter System for Detection of N-acylhomoserine Lactones in Tissue and Clinical Samples." ASM Conference on Cell-Cell Communication in Bacteria, American Society of Microbiology (2004)
"Identification of CepR Regulated Genes using the cep Box Consensus Sequence to Search the Burkholderia cenocepacia J2315 Genome" ASM Conference on Cell-Cell Communication in Bacteria, American Society of Microbiology (2004)
"The CepIR quorum sensing system contributes to virulence in Burkholderia cepacia respiratory infections." Eighth Meeting of the International Burkholderia cepacia Working Group (2003)
"The importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections." ASM Northwest Branch Meeting, American Society of Microbiology (2003)
"N-acyl homoserine lactone mediated interspecies communication between Pseudomonas aeruginosa and Burkholderia cepacia" ASM Conference on Cell-Cell Communication in Bacteria, American Society of Microbiology (2001)
"N-acyl homoserine lactone mediated interspecies communication between Pseudomonas aeruginosa and Burkholderia cepacia" ASM Conference on Cell-Cell Communication in Bacteria, American Society of Microbiology (2001)
"Complex regulation of a potential antibacterial target, the Pseudomonas aeruginosa Tol-OprL cluster." Canadian Bacterial Diseases Network Annual General Meeting, Canadian Bacterial Diseases Network (2000)
Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (2017)
Oral Biology, School of Dental Medicine Graduate Committee, Thesis; Member (2016)
Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (2016)
Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (2015)
Oral Biology, School of Dental Medicine Graduate Committee, Thesis; Member (2015)
School of Dental Medicine Infection Control/Biohazard Committee; Member (2014)
Oral Biology, School of Dental Medicine Graduate Committee, Thesis; Member (2014–2015)
SLB website committee; Committee Member (2017–present)
AADR Buffalo Section; Secretary (2016–2017)
ABRCMS abstract review; review of abstracts for the Annual Biomedical Research Conference for Minority students; Reviewer (2016–present)
ASM Undergraduate Research Fellowship; Reviewer (2016–present)
AADR Edward H. Hatton Awards Committee; Committee Member (2015–2018)
UB Postdoctoral Research Symposium Judge; Judge (2014)
UB School of Dental Medicine Research Day Poster Judge; Judge (2014–present)
Journal Review; Invited to review manuscripts for the International Journal of Oral Science, Journal of Leukocyte Biology, Canadian Journal of Microbiology, The Equine Veterinary Journal, PLos ONE, Microbial Cell Factories, Archives of Oral Biology, Stem Cell and Development, BMC Medical Education, Turkish Journal of Medical Sciences, J of periodontology, Infection Immunity; Ad Hoc Reviewer (2011–present)
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Contact Information
Oral Biology 3435 Main Street Foster Hall 320A Buffalo, NY 14214 Phone: 716-829-3943 mbvisser@buffalo.edu