Keith L. Kirkwood
Keith L. Kirkwood
Professional Summary:
My research program has been focused on innate immune signaling and cytokine biology as it relates to inflammation, bone loss, and oral cancer progression. My translational research explores the roles of posttranscriptional cytokine regulation in oral inflammation with the ultimate possibilities of developing novel therapies to control chronic oral inflammation.
Education and Training:
- Fellowship, Department of Pharmacology and Toxicology, University of Buffalo (1999)
- PhD, University of Buffalo, Dentist Scientist Award (1997)
- Cert, University of Buffalo (1997)
- DDS, West Virginia University (1991)
- BA, West Virginia University, Freshman Chemistry Award, Mary Baab Randolph Student Research Fellowship, (1987)
Employment:
- Professor, Oral Biology, University at Buffalo (2017-present)
- Professor, Oral Health Sciences, Medical University of South Carolina, College of Dental Medicine (2008–2017)
- Associate Professor, Periodontics and Oral Medicine, University of Michigan, School of Dentistry (2003–2008)
- Research Assistant Professor, Pharmacology and Toxicology, University of Buffalo (2002–2003)
- Assistant Professor, Periodontics And Endodontics, University of Buffalo (2000–2003)
- Clinical Assistant Professor, Oral Biology, University of Buffalo (1997–2003)
- Clinical Assistant Professor, Periodontics And Endodontics, University of Buffalo (1997–2000)
- Post Doctoral Fellow, Pharmacology and Toxicology, University of Buffalo (1997–1999)
- Clinical Instructor, Periodontics And Endodontics, University of Buffalo (1995–1997)
Awards and Honors:
- Innovative approaches to prevention and non-surgical treatment of periodontal and peri-implant diseases (2018)
- Sunstar - AAP Foundation Research Fellowship (2016)
- Fellow of the AADR (2016)
- IADR/GSK Innovation in Oral Care Award (2014)
- IADR Distinguished Scientist Award for Pharmacology/Therapeutics/Toxicology Research (2013)
- IADR/GSK Innovation in Oral Care Award (2008)
- Tarrson Fellowship Career Development Award (2005)
- Young Investigator Award (2002)
- Osseointegration Foundation Research Grant Award (2000)
- Student Clinician Award (1990)
- Quintessence Research Award (1990)
- Dentist- Scientist Award
- Mark Diamond Research Award
- Individual National Research Service Award
- American Dental Association Student Clinician Program
- Mary Baab Randolph Student Research Fellowship
- Freshman Chemistry Award
Research Expertise:
- Oral Biology: Cytokine gene regulation in bone with identification of novel therapeutics targets and applied nolecular pharmacology targeting signaling mechanisms for therapeutic purposes in inflammatory bone diseases.
Grants and Sponsored Research:
- October 2018–September 2023
Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis
NIH NIDCR
Role: Principal Investigator
$1,250,000 - September 2018–August 2023
Buffalo Oral-Research and Specialty Training Program (BORST)
national Institutes of Health
Role: Co-Investigator
$1,391,170 - September 2018–August 2023
Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis
national Institutes of Health
Role: Principal Investigator
$1,250,000 - April 2018–March 2023
Acid Sphingomyelinase as a Target in Metabolic Syndrome Exacerbated Periodontitis
national Institutes of Health
Role: Co-Investigator
$47,964 - May 2018–October 2020
Metabolic Reprogramming of Myeloid-derived Suppressor Cells in Post-Traumatic Osteoarthritis
Department of Defense
Role: Principal Investigator
$319,000 - August 2018–July 2020
Sexual Dimorphism of Innate Immunity in Periodontitis through MKP-1 Signaling
national Institutes of Health
Role: Principal Investigator
$438,625
Journal Articles:
- Valerio MS, Alexis F, Kirkwood KL. Functionalized nanoparticles containing MKP-1 agonists reduce periodontal bone loss. J Periodontol. 2019.
- Menzel LP, Ruddick W, Chowdhury MH, Brice DC, Clance R, Porcelli E, Ryan LK, Lee J, Yilmaz Ö, Kirkwood KL, McMahon L, Tran A, Diamond G. Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss. J Periodontal Res. 2019.
- Valerio MS, Kirkwood KL. Sexual Dimorphism in Immunity to Oral Bacterial Diseases: Intersection of Neutrophil and Osteoclast Pathobiology. J Dent Res. 2018.
- Kirkpatrick JE, Kirkwood KL, Woster PM. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5).
- Steinkamp HM, Hathaway-Schrader JD, Chavez MB, Aartun JD, Zhang L, Jensen T, Shojaee Bakhtiari A, Helke KL, Stumpo DJ, Alekseyenko AV, Novince CM, Blackshear PJ, Kirkwood KL. Tristetraprolin Is Required for Alveolar Bone Homeostasis. J Dent Res. 2018; 97(8).
- Needleman I, Garcia R, Gkranias N, Kirkwood KL, Kocher T, Iorio AD, Moreno F, Petrie A. Mean annual attachment, bone level, and tooth loss: A systematic review. J Periodontol. 2018; 89 Su.
- Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018; 89 Su.
- Wilson KR, Kang IH, Baliga U, Xiong Y, Chatterjee S, Moore E, Parthiban B, Thyagarajan K, Borke JL, Mehrotra S, Kirkwood KL, LaRue AC, Ogawa M, Mehrotra M. Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells. Sci Rep. 2018; 8(1).
- Fung B, Fatahzadeh M, Kirkwood KL, Hicks J, Timmons SR. Should Dental Schools Invest in Training Predoctoral Students for Academic Careers? Two Viewpoints: Viewpoint 1: Dental Schools Should Add Academic Careers Training to Their Predoctoral Curricula to Enhance Faculty Recruitment and Viewpoint 2: Addition o J Dent Educ. 2018; 82(4).
- Novince CM, Whittow CR, Aartun JD, Hathaway JD, Poulides N, Chavez MB, Steinkamp HM, Kirkwood KA, Huang E, Westwater C, Kirkwood KL. Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep. 2017; 7(1).
- Valerio MS, Basilakos DS, Kirkpatrick JE, Chavez M, Hathaway-Schrader J, Herbert BA, Kirkwood KL. Sex-based differential regulation of bacterial-induced bone resorption. J Periodontal Res. 2017; 52(3).
- Lu Z, Li Y, Brinson CW, Kirkwood KL, Lopes-Virella MF, Huang Y. CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate. Oral Dis. 2017; 23(2).
- Fribley AM, Svider PF, Warner BM, Garshott DM, Raza SN, Kirkwood KL. Recent Trends in Oral Cavity Cancer Research Support in the United States. J Dent Res. 2017; 96(1).
- Herbert BA, Steinkamp HM, Gaestel M, Kirkwood KL. Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss. Infect Immun. 2017; 85(1).
- Fugle CW, Zhang Y, Hong F, Sun S, Westwater C, Rachidi S, Yu H, Garret-Mayer E, Kirkwood K, Liu B, Li Z, Kirkwood KL. CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. Oncoimmunology. 2016; 5(10).
- Herbert BA, Novince CM, Kirkwood KL. Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Mol Oral Microbiol. 2016; 31(3).
- Herbert BA, Valerio MS, Gaestel M, Kirkwood KL. Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations. PLoS One. 2015; 10(5).
- Valerio MS, Herbert BA, Basilakos DS, Browne C, Yu H, Kirkwood KL. Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. 2015; 71(1).
- Zhang X, Hyer JM, Yu H, D'Silva NJ, Kirkwood KL. DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma. Cancer Res. 2014; 74(24).
- Jin J, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Yu H, Haycraft CJ, Li Q, Kirkwood KL, Huang Y. Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. J Periodontal Res. 2014; 49(4).
- Intini G, Katsuragi Y, Kirkwood KL, Yang S. Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions. Adv Dent Res. 2014; 26(1).
- Banerjee R, Van Tubergen EA, Scanlon CS, Vander Broek R, Lints JP, Liu M, Russo N, Inglehart RC, Wang Y, Polverini PJ, Kirkwood KL, D'Silva NJ. The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer. Mol Cancer Ther. 2014; 13(5).
- Valerio MS, Herbert BA, Griffin AC, Wan Z, Hill EG, Kirkwood KL. MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation. Bone. 2014; 60.
- Guimarães MR, Leite FR, Spolidorio LC, Kirkwood KL, Rossa C. Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK. Arch Oral Biol. 2013; 58(10).
- Travan S, Li F, D'Silva NJ, Slate EH, Kirkwood KL. Differential expression of mitogen activating protein kinases in periodontitis. J Clin Periodontol. 2013; 40(8).
- Van Tubergen EA, Banerjee R, Liu M, Vander Broek R, Light E, Kuo S, Feinberg SE, Willis AL, Wolf G, Carey T, Bradford C, Prince M, Worden FP, Kirkwood KL, D'Silva NJ. Inactivation or loss of TTP promotes invasion in head and neck cancer via transcript stabilization and secretion of MMP9, MMP2, and IL-6. Clin Cancer Res. 2013; 19(5).
- Zhang X, Junior CR, Liu M, Li F, D'Silva NJ, Kirkwood KL. Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss. Oral Oncol. 2013; 49(2).
- Sambandam Y, Sundaram K, Liu A, Kirkwood KL, Ries WL, Reddy SV. CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor-bone microenvironment. Oncogene. 2013; 32(1).
- Qin Z, Dai L, Defee M, Findlay VJ, Watson DK, Toole BP, Cameron J, Peruzzi F, Kirkwood K, Parsons C, Kirkwood KL. Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol. 2013; 87(1).
- Griffin AC, Kern MJ, Kirkwood KL. MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function. Mol Endocrinol. 2012; 26(10).
- Rossa C, Sommer G, Spolidorio LC, Rosenzweig SA, Watson DK, Kirkwood KL. Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS One. 2012; 7(9).
- Palanisamy V, Jakymiw A, Van Tubergen EA, D'Silva NJ, Kirkwood KL. Control of cytokine mRNA expression by RNA-binding proteins and microRNAs. J Dent Res. 2012; 91(7).
- Dai L, Qin Z, Defee M, Toole BP, Kirkwood KL, Parsons C. Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts. Cancer Lett. 2012; 318(2).
- Ge C, Yang Q, Zhao G, Yu H, Kirkwood KL, Franceschi RT. Interactions between extracellular signal-regulated kinase 1/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J Bone Miner Res. 2012; 27(3).
- Guimarães MR, de Aquino SG, Coimbra LS, Spolidorio LC, Kirkwood KL, Rossa C. Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats. Innate Immun. 2012; 18(1).
- Li Q, Valerio MS, Kirkwood KL. MAPK usage in periodontal disease progression. J Signal Transduct. 2012; 2012.
- Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011; 10(5).
- Mahalingam CD, Datta T, Patil RV, Kreider J, Bonfil RD, Kirkwood KL, Goldstein SA, Abou-Samra AB, Datta NS. Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone. J Endocrinol. 2011; 211(2).
- Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011; 56(2).
- Zhao W, Liu M, D'Silva NJ, Kirkwood KL. Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region. J Interferon Cytokine Res. 2011; 31(8).
- Van Tubergen E, Vander Broek R, Lee J, Wolf G, Carey T, Bradford C, Prince M, Kirkwood KL, D'Silva NJ. Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma. Cancer. 2011; 117(12).
- Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL. Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011; 18(4).
- Krayer JW, Leite RS, Kirkwood KL. Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases. Dent Clin North Am. 2010; 54(1).
- Yuvaraj S, Griffin AC, Sundaram K, Kirkwood KL, Norris JS, Reddy SV. A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells. Mol Cancer Res. 2009; 7(8).
- Kirkwood KL, Rossa C. The potential of p38 MAPK inhibitors to modulate periodontal infections. Curr Drug Metab. 2009; 10(1).
- Patil CS, Liu M, Zhao W, Coatney DD, Li F, VanTubergen EA, D‘Silva NJ, Kirkwood KL. Targeting mRNA stability arrests inflammatory bone loss. Mol Ther. 2008; 16(10).
- Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JM, Pan Q, Carey TE, Bradford CR, Prince ME, Cordell KG, Kirkwood KL, D'Silva NJ. Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Res. 2008; 68(10).
- Rossa C, Liu M, Kirkwood KL. A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-kappaB ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharide. J Periodontal Res. 2008; 43(2).
- Zhao W, Liu M, Kirkwood KL. p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements. J Biol Chem. 2008; 283(4).
- Ishi EDE P, Bertolo MB, Rossa C, Kirkwood KL, Onofre MA. Periodontal condition in patients with rheumatoid arthritis. Braz Oral Res. 2008; 22(1).
- Rogers JE, Li F, Coatney DD, Otremba J, Kriegl JM, Protter TA, Higgins LS, Medicherla S, Kirkwood KL. A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model. J Periodontol. 2007; 78(10).
- Solomon LW, Neiders ME, Zwick MG, Kirkwood KL, Kumar V. Autoimmunity to deltaNp63alpha in chronic ulcerative stomatitis. J Dent Res. 2007; 86(9).
- Patil CS, Kirkwood KL. p38 MAPK signaling in oral-related diseases. J Dent Res. 2007; 86(9).
- Solomon L, Neiders M, Zwick MG, Kirkwood KL, Kumar V. Autoimmunity to deltaNp63alpha in chronic ulcerative stomatitis. J Dent Res. 2007; 86(9).
- Lei P, Ogunade A, Kirkwood KL, Laychock SG, Andreadis ST. Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes. Tissue Eng. 2007; 13(8).
- Henson B, Li F, Coatney DD, Carey TE, Mitra RS, Kirkwood KL, D'Silva NJ. An orthotopic floor-of-mouth model for locoregional growth and spread of human squamous cell carcinoma. J Oral Pathol Med. 2007; 36(6).
- Rogers JE, Li F, Coatney DD, Rossa C, Bronson P, Krieder JM, Giannobile WV, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol. 2007; 78(3).
- Kirkwood KL, Cirelli JA, Rogers JE, Giannobile WV. Novel host response therapeutic approaches to treat periodontal diseases. Periodontol 2000. 2007; 43.
- Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM, D'Silva NJ, Chakravarty S, Dugar S, Higgins LS, Protter AA, Medicherla S. A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther. 2007; 320(1).
- Rossa C, Liu M, Bronson P, Kirkwood KL. Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase. J Endotoxin Res. 2007; 13(2).
- Patil C, Rossa C, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts. Oral Microbiol Immunol. 2006; 21(6).
- Rossa C, Ehmann K, Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells. J Interferon Cytokine Res. 2006; 26(10).
- Rossa C, Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol. 2005; 24(7).
- Kim YJ, Rossa C, Kirkwood KL. Prostaglandin production by human gingival fibroblasts inhibited by triclosan in the presence of cetylpyridinium chloride. J Periodontol. 2005; 76(10).
- Martinez AE, Silverio KG, Fogo JC, Kirkwood KL, Rossa C. Root surface conditioning with nicotine or cotinine reduces viability and density of fibroblasts in vitro. Clin Oral Investig. 2005; 9(3).
- Al-Sabek F, Shostad S, Kirkwood KL. Preferential attachment of human gingival fibroblasts to the resin ionomer Geristore. J Endod. 2005; 31(3).
- Patil C, Zhu X, Rossa C, Kim YJ, Kirkwood KL. p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Invest. 2004; 33(2).
- Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL. Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem. 2004; 279(4).
- Kirkwood KL. Update on antibiotics used to treat orofacial infections. Alpha Omegan. 2003; 96(4).
- Kirkwood K, Martin T, Andreadis ST, Kim YJ, Kirkwood KL. Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability. Biochem Pharmacol. 2003; 66(9).
- Koria P, Brazeau D, Kirkwood K, Hayden P, Klausner M, Andreadis ST. Gene expression profile of tissue engineered skin subjected to acute barrier disruption. J Invest Dermatol. 2003; 121(2).
- Bradford PG, Maglich JM, Kirkwood KL. IL-1 beta increases type 1 inositol trisphosphate receptor expression and IL-6 secretory capacity in osteoblastic cell cultures.. Mol Cell Biol Res Commun. 2000; 3(2).
- Bradford PG, Maglich JM, Ponticelli AS, Kirkwood KL. The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures.. Arch Oral Biol. 2000; 45(2).
- Kirkwood KL, Golub LM, Bradford PG. Non-antimicrobial and antimicrobial tetracyclines inhibit IL-6 expression in murine osteoblasts.. Ann N Y Acad Sci. 1999; 878.
- Kirkwood KL, Homick K, Dragon MB, Bradford PG. Cloning and characterization of the type I inositol 1,4,5-trisphosphate receptor gene promoter. Regulation by 17beta-estradiol in osteoblasts.. J Biol Chem. 1997; 272(36).
- Strobl JS, Kirkwood KL, Lantz TK, Lewine MA, Peterson VA, Worley JF. Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine.. Cancer Res. 1990; 50(17).
- Ruddy M, Kirkwood KL, Gaffen S. IL-17 synergizes with TNF but not Toll-like receptors to induce inflammatory cytokines in osteoblasts.. Manuscript in Preparation..
Books and Book Chapters:
- Kirkwood KL, Nisengard RJ, Haake SK, Miyasaki KT. Immunity and Inflammation: Basic Concepts. Carranza's Clinical Periodontology, 10th Edition. 2007.
Abstracts:
- Kirkwood K, Ciancio SG, Mather M. Clinical evaluation of a smoking deterrent breathspray compared to a placebo spray. J Dent Res. 2002; 81(2328).
- Kirkwood K, Ciancio SG, Mather M. Clinical evaluation of a smoking deterrent mouthwash. J Dent Res. 2001; 80(1504).
- Kirkwood KL, Dziak R, Bradford P. Inositol trisphosphate receptor subtype analysis in human osteosarcona cells.. J Dent Res. 1995; 74(318).
- Kirkwood KL, Wilson ME. IgG antibodies to A. actinomycetemcomitans 16.6 kDa OMP in juvenile periodontitis.. J Dent Res. ; 73(451).
Professional Memberships:
- American Association of Dental Research; Secretary/Treasurer (2002–2005)
- American Academy of Periodontology; Subcommittee on Research Submission (2001–present)
- American Dental Association
- New York State Dental Association
- Eight District Dental & Erie County Dental Societies
- New York State Society of Periodontists
- Academy of Osseointegration
- American Association for Bone and Mineral Research
Presentations:
- "Differential Regulation of MMP-13 by Chemical Modified Tetracyclines in Osteoblasts" 8oth Annual Session of the IADR/31th (2002)
- "Dental Implications of the 40 Most Commonly Prescribed Medications" Continuing Dental Medicine, University of Buffalo Dental Medicine (2001)
- "Systemic Medications and Dental Implications" , University of Rochester (2001)
- "Impact of Herbal Therapies on Dental Practice" Continuing Dental Education, University of Buffalo Dental Medicine (2001)
- "Expression Profiling of Genes Regulated by Chemically Modified Tetracycline-8 in Murine Osteoblasts Cellsc Cells" Annual Session of the AADR (2001)
- "The Effects of Titanium-Immobilized bioactive Peptides on Osteoblast Differentiation" Osseointegration Academy Meeting (2001)
- "Chemically Modified Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" 78th Annual Session of the IADR/29th (2000)
- "Gene regulation by chemically Modifed Tetracylines in Murine Osteoblasts" Gordon Research Conference (1999)
- "Non-Antimicrobial and Antimicrobial Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" New York Academy of Sciences Meeting (1998)
- "OP-1 Induction of the Inositol Trisphosphate Receptor in Human Osteosarcoma Cells" 75th Annual Session of the AADR/25th (1997)
- "Inositol Trisphosphate Receptor Subtype Analysis in Human Osteosarcoma Cells" 24th Session of ther AADR (1995)
- "IgG Antibodies to A.Actinomycetemconitans 16.6 Kda OMP In Juvenile Periodontitis" 72nd Annual Session of the IADR/23th (1994)
- "Selective Expression of Inositol Trisphosphate Rectptor Gene In Human Osteosarcoma Cells" 22nd Annual Session of the AADR (1993)
Service Activities:
- School of Dental Medicine Executive Council; Member (2019)
- Oral Biology, School of Dental Medicine Graduate Committee, Recruiting; Member (2019)
- School of Dental Medicine Research Committee; Member (2017–2020)
- School of Dental Medicine Student Research and Honors Committee (2017–2020)
- School of Dental Medicine ByLaws Committee (2000)
- School of Dental Medicine Curriculum Committee (2000)
- School of Dental Medicine Student Research and Honors Committee (2000)