Jill Kramer
Jill Kramer
Associate professor
Specialty/Research Focus
Oral Biology; Oral Pathology
Education and Training:
- Residency, Oral and Maxillofacial Pathology, North Shore-LIJ Health System (2010)
- PhD, Oral Biology, SUNY at Buffalo (2007)
- DDS, Dentistry, SUNY at Buffalo (2006)
- BS, Molecular Biology, Grove City College, Magna cum laude (1999)
Employment:
- Associate Professor, Oral Biology, SUNY at Buffalo (2020-present)
- Assistant Professor, Oral Biology, SUNY at Buffalo (2013–2019)
- Assistant Professor, Oncology and Cell Biology, The Feinstein Institute for Medical Research (2010–2012)
- Assistant Attending, Dental Medicine, Long Island Jewish Medical Center (2010–2012)
- Assistant Professor, Dental Medicine, Hofstra North Shore-LIJ School of Medicine (2010–2012)
- Resident, Dental Medicine, Long Island Jewish Medical Center (2007–2010)
Awards and Honors:
- ADEA/AADR/Colgate-Palmolive Co./Dr. Dominick P. DePaola Scholarship in the ADEA Leadership Institute. (2022)
- NYSDF Dr. Edward J. Downes Fellowship (2014)
- Waldron Award Winner (2012)
- North Shore-LIJ Health System Annual Academic Competition Winner, First place (2010)
- Gorlin Award Winner (2009)
- North Shore-LIJ Health System Annual Academic Competition Winner, Second place (2008)
Research Expertise:
- Sjogren's Syndrome
Grants and Sponsored Research:
- April 2020–March 2025
Analysis of MyD88-mediated immune activation in Sjogrens syndrome pathogenesis
NIH/National Institute of Dental and Craniofacial Research
Role: Principal Investigator
$1,866,331 - September 2018–August 2020
Analysis of B cell activation by endogenous mediators of inflammation in Sjögren's syndrome
NIH NIDCR
Role: Principal Investigator
$438,625 - September 2018–August 2020
Analysis of B cell activation by endogenous mediators of inflammation in Sjogren's syndrome
NIH/NIDCR
Role: Principal Investigator - June 2019–July 2020
University at Buffalo Blue Sky Funded Project: Sjögren's syndrome at single-cell resolution
SUNY at Buffalo
Role: Co-Investigator
$30,000 - August 2018–July 2020
Single chemosensory cells in the salivary gland
NIH/NIDCR
Role: Co-Principal Investigator
$24,174 - July 2018–June 2020
Analysis of the Role of IgM in Sjögren's syndrome
NIH NIDCR
Role: Principal Investigator
$319,000 - August 2018–September 2019
American Assoc. of Immunologists Careers in Immunology Fellowship Award
American Association of Immunologists
Role: Principal Investigator
$24,324 - September 2017–August 2019
Analysis of MyD88-mediated immune activation in Sjogren‘s syndrome pathogenesis
NIH NIDCR
Role: Principal Investigator
$357,357 - July 2010–June 2015
Autoantibodies and B Cell Chemotaxis in Sjogren's Syndrome
NIDCR
Role: Principal Investigator
Patents:
- Identification and method for using the pre-ligand assembly domain of the I (2013)
Journal Articles:
- Punnanitinont A, Kasperek EM, Kiripolsky J, Zhu C, Miecznikowski JC, Kramer JM, Kramer J. TLR7 agonism accelerates disease in a mouse model of primary Sjögren's syndrome and drives expansion of T-bet+ B cells. Front Immunol. 2022; 13.
- Kiripolsky J, Kasperek EM, Zhu C, Li QZ, Wang J, Yu G, Kramer JM. Immune-Intrinsic Myd88 Directs the Production of Antibodies With Specificity for Extracellular Matrix Components in Primary Sjogren‘s Syndrome. Front Immunol. 2021; 12.
- Kiripolsky, J, Kaperek, EM, Zhu, C, Li, QZ, Wang, J, Yu, G, Kramer J. Tissue-specific activation of Myd88-dependent pathways governs disease severity in primary Sjögren‘s syndrome. Journal of Autoimmunity. 2021; 118.
- Oyelakin A, Horeth E, Song EC, Min S, Che M, Marzullo B, Lessard CJ, Rasmussen A, Radfar L, Scofield RH, Lewis DM, Stone DU, Grundahl K, De Rossi SS, Kurago Z, Farris AD, Sivils KL, Sinha S, Kramer JM, Romano RA. Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjogren‘s Syndrome. Front Immunol. 2021; 11.
- Kiripolsky J, Romano RA, Kasperek EM, Yu G, Kramer JM. Activation of Myd88-Dependent TLRs Mediates Local and Systemic Inflammation in a Mouse Model of Primary Sjogren‘s Syndrome. Front Immunol. 2020; 10.
- Kay JG, Kramer JG, Visser MB. Danger signals in oral cavity-related diseases. J Leukoc Biol. 2019.
- Ritchie A and Kramer J. Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome. J Dent Res. 2018.
- Zaki H, Sabharwal A, Kramer J, Aguirre A. Laugier-Hunziker Syndrome Presenting with Metachronous Melanoacanthomas. Head Neck Pathol. 2018.
- Kiripolsky J, McCabe LG, Gaile DP, Kramer JM. Myd88 is required for disease development in a primary Sjogren‘s syndrome mouse model. J Leukoc Biol. 2017.
- Alshagroud R, Neiders M, Kramer JM, Suresh L. Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017.
- Kiripolsky J, Shen L, Liang Y, Li A, Suresh L, Lian Y, Li QZ, Gaile DP, Kramer JM. Systemic manifestations of primary Sjogren‘s syndrome in the NOD.B10Sn-H2(b)/J mouse model. Clin Immunol. 2017.
- Alhousami T, Sabharwal A, Gupta S, Aguirre A, Park E, Kramer JM. Fibromyxoma of the Jaw: Case Report and Review of the Literature. Head Neck Pathol. 2017.
- Kiripolsky J, McCabe LG, Kramer JM. Innate immunity in Sjogren‘s syndrome. Clin Immunol. 2017.
- Aljanobi H, Sabharwal A, Krishnakumar B, Kramer JM. Is it Sjogren‘s syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017; 123(4).
- Mair YH, Jhamb T, Visser MB, Aguirre A, Kramer JM. Sera and salivary matrix metalloproteinases are elevated in patients with vesiculoerosive disease: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 121(5).
- Sharma A, Kiripolsky J, Klimatcheva E, Howell A, Fereidouni F, Levenson R, Rothstein TL, Kramer JM. Early BAFF receptor blockade mitigates murine Sjögren‘s syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction. Clin Immunol. 2016; 164.
- Kramer JM, Holodick NE, Vizconde TC, Raman I, Yan M, Li QZ, Gaile DP, Rothstein TL. Analysis of IgM antibody production and repertoire in a mouse model of Sjögren‘s syndrome. J Leukoc Biol. 2016; 99(2).
- Ray DB, Merrill GA, Brenner FJ, Lytle LS, Lam T, McElhinney A, Anders J, Rock TT, Lyker JK, Barcus S, Leslie KH, Kramer JM, Rubenstein EM, Pryor Schanz K, Parkhurst AJ, Peck M, Good K, Granath KL, Cifra N, Detweiler JW, Stevens L, Albertson R, Deir R, Stewart E, Wingard K, Richardson MR, Blizard SB, Gillespie LE, Kriley CE, Rzewnicki DI, Jones DH. T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA. Exp Cell Res. 2016; 340(1).
- Husain-Krautter S, Kramer JM, Li W, Guo B, Rothstein TL. The osteopontin transgenic mouse is a new model for Sjögren‘s syndrome. Clin Immunol. 2015; 157(1).
- Kramer JM. Current concepts in Sjögren‘s syndrome and considerations for the dental practitioner. N Y State Dent J. 2015; 81(1).
- Jhamb T, Kramer JM. Molecular concepts in the pathogenesis of ameloblastoma: implications for therapeutics. Exp Mol Pathol. 2014; 97(3).
- Baker OJ, Edgerton M, Kramer JM, Ruhl S. Saliva-microbe interactions and salivary gland dysfunction. Adv Dent Res. 2014; 26(1).
- Mongini PK, Kramer JM, Ishikawa TO, Herschman H, Esposito D,. Candidate chromosome 1 disease susceptibility genes for Sjogren‘s syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clin Immunol. 2014.
- Kramer JM, Klimatcheva E, Rothstein TL. CXCL13 is elevated in Sjögren‘s syndrome in mice and humans and is implicated in disease pathogenesis. J Leukoc Biol. 2013; 94(5).
- Dasa V, Kramer JM, Gaffen SL, Kirkwood KL, Mihalko WM. Is monocyte chemotactic protein 1 elevated in aseptic loosening of TKA? A pilot study. Clin Orthop Relat Res. 2012; 470(7).
- Kramer JM, Hanel W, Shen F, Isik N, Malone JP, Maitra A, Sigurdson W, Swart D, Tocker J, Jin T, Gaffen SL. Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol. 2007; 179(10).
- Kramer JM, Gaffen SL. Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J Periodontol. 2007; 78(6).
- Gaffen S, Kramer JM, Yu JJ, Shen F. The IL-17 cytokine family. Vitam Horm. 2006; 74.
- Kramer JM, Yi L, Shen F, Maitra A, Jiao X, Jin T, Gaffen SL. Cutting edge: Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol. 2006; 176.
Abstracts:
- Kramer J, Gaffen S. Elucidation of the IL-17 receptor configuration.. Poster - International Association of Dental Researchers (IADR) Meeting, San Diego, CA.. 2001.
Evaluative Studies and Case Reports:
- Doscher JC, Kramer JM, Fantasia JE. A large calcifying lesion of the maxilla in a child. J Am Dent Assoc. 2011; 142(9).
- Kramer JM, Doscher JC, Ruvinsky M, Fantasia JE. Calcifying aponeurotic fibroma with bone islands exhibiting hematopoiesis: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(6).
Professional Memberships:
- Society for Leukocyte Biology (2013–present)
- American Association of Immunologists (2010–present)
- American Academy of Oral and Maxillofacial Pathology (2008–present)
- Sjogren's Syndrome Foundation (2008–present)
- American Association for the Advancement of Science (2007–present)
- ADA (2006–present)
- New York State Dental Association (2006–present)
- AADR (2001–present)
Presentations:
- "Autoantibody Production in Sjögren’s Syndrome" American Academy of Oral and Maxillofacial Pathology 67th Annual Meeting, American Academy of Oral and Maxillofacial Pathology (2013)
- "CXCL13 in Sjögren’s Syndrome is connected to disease and represents a clinical biomarker" , University of California San Francisco School of Dentistry (2012)
- "Clinical Pathologic Conference Case Presentation (Case #5)" American Academy of Oral and Maxillofacial Pathology 66th Annual Meeting, American Academy of Oral and Maxillofacial Pathology (2012)
- "CXCL13 in Sjögren’s Syndrome is connected to disease and represents a clinical biomarker" , James D. Edwards College of Dental Medicine, Medical University of South Carolina (2012)
- "CXCL13 is a novel biomarker for Sjögren’s Syndrome in humans and mice" , Robert C. Byrd Health Sciences Center School of Dentistry, West Virginia University (2012)
- "CXCL13 is a novel biomarker for Sjögren’s Syndrome in humans and mice" , Department of Medicine, University of Pittsburgh (2012)
- "Clinical Case Presentations" Eastern Society of Teachers of Oral Pathology (ESTOP) Conference (2011)
- "Analysis of the Chemokine CXCL13 in Sjögren’s Syndrome" , Case School of Dental Medicine, Case Western Reserve University (2011)
- "CXCL13 in Sjögren’s Syndrome: A novel biomarker of disease (Abstract #5)" American Academy of Oral and Maxillofacial Pathology 64th Annual Meeting, American Academy of Oral and Maxillofacial Pathology (2010)
- "Clinical Case Presentations" The Gorlin Conference (2009)
- "Clinical Case Presentations" Eastern Society of Teachers of Oral Pathology (ESTOP) Conference (2009)
- "Emerging Role of CXCL13 and B1 Lymphocytes in Sjögren’s Syndrome (Abstract #6)" Albert Einstein College of Medicine Pathology Residents’ Research Night (2009)
- "Clinical Case Presentations" The Gorlin Conference (2008)
- "Emerging Role of CXCL13 and B1 Lymphocytes in Sjögren’s Syndrome (Abstract #6)" American Academy of Oral and Maxillofacial Pathology 63rd Annual Meeting, American Academy of Oral and Maxillofacial Pathology (2008)
- "Clinical Case Presentations" The Gorlin Conference (2007)
- "Clinical Case Presentations" Eastern Society of Teachers of Oral Pathology (ESTOP) Conference (2007)
- "IL-17 Receptor Dynamics Including FRET Analysis" Upstate New York Immunology Conference (2006)
- "Evidence for Multimerization of the IL-17 Receptor: Association with IL-17RC" International Association for Dental Research Conference, International Association for Dental Research (2006)
Service Activities:
- School of Dental Medicine Student Research and Honors Committee; Co-Chair (2015)
- Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (2013)
- Oral Biology, School of Dental Medicine Graduate Committee, Admissions (2013)
- AADR Buffalo Section; President (2015–2016)
- IADR Salivary Research Group; Director (2015–2016)
- AADR nominating committee; Member (2014–2016)
- AAOMP nominating committee; Advisory Committee (2014–2015)
- Ad hoc reviewer; Ad Hoc Reviewer (2013–2014)
- Ad hoc Reviewer; Ad Hoc Reviewer (2006–present)