Hyuk-Jae (Edward) Kwon
Hyuk-Jae (Edward) Kwon
Assistant Professor HS
Specialty/Research Focus
Oral Biology
Professional Summary:
I am a new investigator with a unique background of a combination of dual doctoral degrees (a D.D.S. and a Ph.D. in Dental/Craniofacial Development). I recently completed the UB Clinical and Translational Science Institute (CTSI) K Scholar Program.
My research activities focus on the genetic and epigenetic control of mammalian dental and craniofacial development and pathogenesis, with a specific emphasis on congenital dental anomalies and orofacial clefts. My lab uses developmental mouse genetics, experimental embryology, molecular biology, and genomic approaches to dissect the molecular mechanisms that control dental and craniofacial organogenesis. My research is currently supported by the NIH NCATS (UL1) and NIDCR (R03) and by Colgate-Palmolive (C.A.R.E. Award).
Education and Training:
- Postdoctoral Fellow, Developmental Biology, Cincinnati Children‘s Hospital Medical Center (2017)
- PhD, Developmental Biology, Yonsei University Graduate School (2011)
- DDS, Dentistry, Yonsei University College of Dentistry (2006)
Employment:
- Research Fellow, Department of Developmental Biology, Cincinnati Children‘s Hospital Medical Center (2012–2017)
- Teaching Assistant, Oral Biology, Yonsei University, College of Dentsitry, Korea, Republic Of (2006–2011)
Awards and Honors:
- UB Clinical & Translational Science Institute (CTSI) K Scholar Program Award (5KL2TR0013-05) (2020)
- 1st Place Poster Award, 5th Annual Craniofacial and Skin Sciences Research Symposium (2016)
- 2nd Place Poster Award, 4th Annual Craniofacial and Skin Sciences Research Symposium Research Symposium (2015)
- 2nd Place Poster Award, “Developmental Mechanisms, Organogenesis, and Stem Cells” Cincinnati Children‘s Hospital Medical Center Annual Retreat (2015)
- Most Outstanding Student-Dentist Award, Yonsei University College of Dentistry, Seoul, Korea (2006)
- ADA/Dentsply Student Clinician Research Program (SCADA) Travel Award (2004)
- 1st Place Award, National Dental Student Research Award Competition of Korea (2003)
Research Expertise:
- Dental and Craniofacial Developmental Biology: Studying the genetic basis and molecular mechanisms underlying dental and craniofacial development and disorders using molecular, genetic, and genomic approaches.
Grants and Sponsored Research:
- December 2022–November 2023
Colgate Award for Research Excellence (CARE)
Colgate-Palmolive
Role: Principal Investigator
$39,000 - August 2021–July 2023
R03 NIH/NIDCR
NIDCR
Role: Principal Investigator
$319,000 - January 2022–December 2022
UB CTSI Translational Pilot Studies Program Grant
NIH/NCATS
Role: Co-Investigator
$46,500 - July 2020–June 2022
UB CTSA-Linked KL2 Mentored Career Development Award Program
NIH/NCATS
Role: Principal Investigator
$220,000
Journal Articles:
- J-M Lee, C Qin, OH Chai, Y Lan, R Jiang, H-JE Kwon. MSX1 drives tooth morphogenesis through controlling Wnt signaling activity. J Dent Res. 2022; 101(7).
- Kwon HE, Jia S, Lan Y, Liu H, Jiang R. Activin and Bmp4 signaling converge on Wnt activation during odontogenesis J Dent Res. 2017; 96(10).
- Jia S, Kwon HE, Lan Y, Zhou J, Liu H, Jiang R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists Dev Biol. 2016; 420(1).
- Kwon HJ, Li L, Jung HS. Hippo pathway/Yap regulates primary enamel knot and dental cusp patterning in tooth morphogenesis. Cell Tissue Res. 2015; 362(2).
- Kwon HJE, Park EK, Jia S, Liu H, Lan Y, Jiang R. Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice J Dent Res. 2015; 94(8).
- Li L*, Kwon HJ*, Harada H, Ohshima H, Cho SW, Jung HS *Equal contribution. Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor Gene Expr Patterns. 2011; 11(3-4).
- Park JC, Kwon HJE, Chung CW. Innovative digital tools for new trends in teaching and assessment methods in medical and dental education. Journal of Educational Evaluation for Health Professions. 2021; 18(13).
- Li L, Tang Q, Kim EJ, Wu Z, Kwon HJE, Jung HS. An Explanation for How FGFs Predict Species-Specific Tooth Cusp Patterns J Dent Res. 2018; 97(7).
- Pang X, Kwon HJ, Shi B, Li C. A Rare Nasopharyngeal Teratoma Arising From the Vomer J Craniofac Surg. 2016; 27(2).
- Green DW*, Kwon HJ*, Jung HS *equal contribution. Osteogenic potency of nacre on human mesenchymal stem cells Mol Cells. 2015; 38(3).
- Xu X, Kwon HJ, Shi B, Zheng Q, Yin H, Li C. Influence of different palate repair protocols on facial growth in unilateral complete cleft lip and palate J Craniomaxillofac Surg. 2015; 43(1).
- Lee JM*, Kwon HJ*, Lai WF, Jung HS *equal contribution. Requirement of Runx3 in pulmonary vasculogenesis Cell Tissue Res. 2014; 356(2).
- Kwon HJ, Yoon KS, Jung HS. Expression patterns of Ki-67, cyclin A, and cyclin D1 during tooth development. Korean J Phys Anthrop. 2013; 26(1).
- Shin JO, Kim EJ, Cho KW, Nakagawa E, Kwon HJ, Cho SW, Jung HS. BMP4 signaling mediates Zeb family in developing mouse tooth Histochem Cell Biol. 2012; 137(6).
- Cho KW, Kwon HJ, Shin JO, Lee JM, Cho SW, Tickle C, Jung HS. Retinoic acid signaling and the initiation of mammary gland development Dev Biol. 2012; 1(365).
- Shin JO, Lee JM, Cho KW, Kwak SW, Kwon HJ, Lee MJ, Cho SW, Kim KS, Jung HS. MiR-200b is involved in Tgf-ƒÀ signaling to regulate mammalian palate development Histochem Cell Biol. 2012; 137(1).
- Lee JM, Miyazawa S, Shin JO, Kwon HJ, Kang DW, Choi BJ, Lee JH, Kondo S, Cho SW, Jung HS. Shh signaling is essential for rugae morphogenesis in mice Histochem Cell Biol. 2011; 136(6).
- Kwon HJ, Shin JO, Lee JM, Cho KW, Lee MJ, Cho SW, Jung HS. Retinoic acid modulates chondrogenesis in the developing mouse cranial base J Exp Zool B Mol Dev Evol. 2011; 316(8).
- Kwon HJ, Park GH, Kim EJ, Lee MJ, Jung HS, Cho SW. An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ Korean J Phys Anthrop. 2011; 24(4).
- Kwon HJ, Lee JM, Cho KW, Shin JO, Cho SW, Lee MJ, Jung HS. The role of microtubule in the regulation of endochondral bone formation in the developing mouse cranial base Korean J Phys Anthrop. 2011; 24(2).
- Lee JM, Kwon HJ, Bae SC, Jung HS. Lung tissue regeneration after induced injury in Runx3 KO mice Cell Tissue Res. 2010; 341(3).
- Sasaki H, Muramatsu T, Kwon HJ, Yamamoto H, Hashimoto S, Jung HS, Shimono M. Down-regulated genes in mouse dental papillae and pulp J Dent Res. 2010; 89(7).
- Lee MJ, Han KJ, Kwon HJ, Jung HS, Cho SW. Effects of hyaluronan on carrageenan-induced synovitis in rat TMJ Anat Cell Biol. 2010; 43(2).
- Kim YJ*, Kwon HJ*, Shinozaki N, Hashimoto S, Shimono M, Cho SW, Jung HS * Equal contribution. Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland Cell Tissue Res. 2008; 334(1).
- Kim YJ, Kim JY, Cho JW, Cha DS, Lee MJ, Osamu T, Kwon HJ, Cho KH, Lee JH, Song CW, Jung HS. Implications for tooth development on ENU-induced ectodermal dysplasia mice Birth Defects Res B Dev Reprod Toxicol. 2008; 83(2).
- Hu KS, Yun HS, Hur MS, Kwon HJ, Abe S, Kim HJ. Branching patterns and intraosseous course of the mental nerve J Oral Maxillofac Surg. 2007; 65(11).
Professional Memberships:
- Society for Developmental Biology; Professional organization for developmental Biologists (2019)
- American Society of Craniofacial Surgery (2016–present)
- Society for Developmental Biology; SDB ID: 11572 (2014–2016)
Presentations:
- "Epigenetic regulation of palate development" 15th World Congress of the International Cleft Lip and Palate Foundation (ICPF 2023), International Cleft Lip and Palate Foundation (ICPF), Basic Science Studies (2023)
- "Epigenetic regulation of palate formation" 20th International Federation of Associations of Anatomists (IFAA 2022), International Federation of Associations of Anatomists (IFAA), “Craniofacial Development and Regeneration” Symposium (2022)
- "A dentist-scientist's career path: Searching for a better treatment for dental diseases" Graduate and Professional Careers in Biomedical and Behavioral Sciences Forum., UB Jacobs School of Medicine and Biomedical Sciences (2022)
- "Understanding morphogenesis through tooth development" UB Biological Sciences Department Seminar (virtual), UB College of Arts and Sciences (Department of Biological Sciences) (2020)
- "Tooth development: Understanding the odontogenic potential" Invited seminar, Yonsei University College of Dentistry [Brain Korea (BK) 21 and the Taste Research Center] (2019)
- "Tooth morphogenesis: a model for understanding cell-cell signaling interaction during organogenesis" 18th Annual Meeting of the Korean Basic Dental Science Society Association (KBDSSA), Korean Basic Dental Science Society Association (KBDSSA) (2019)
- "Tooth morphogenesis: Genetic interaction between Msx1 and Sostdc1 during mouse" Invited seminar, Pusan National University School of Dentistry (Dental and Life Science Institute) (2019)
- "Using mouse developmental genetics to study tooth agenesis" Invited special lecture, Yonsei University College of Dentistry (Department of Orthodontics). (2019)
- "Understanding dental development and birth defects using mice" AADR Buffalo Section Lunch and Learn Seminar Series, American Association of Dental Research, Buffalo section, American Association of Dental Research (2018)
- "Using tooth development as a model for understanding signaling interactions between tissues during organogenesis" UB JSMB BCH Seminar Series, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, UB JSMB Department of Biochemistry (2017)
- "The Bmp4-Msx1 pathway controls early odontogenesis through regulation of expression of secreted Wnt antagonists" 5th Annual Craniofacial and Skin Sciences Research Symposium, Cincinnati Children's Hospital Medical Center, Cincinnati Children's Hospital Medical Center (2016)
- "Activin and Bmp4 signaling converge on Wnt pathway activation to drive tooth organogenesis" Seminar Series, Kyungpook National University, School of Dentistry (2015)
- "Activin and Bmp4 signaling converge on Wnt pathway activation to drive tooth organogenesis" Seminar Series, Yonsei University, College of Dentistry (2015)
Service Activities:
- Oral Biology, School of Dental Medicine Graduate Committee, Admissions; Alternate Member (2018–2020)
- PPBS Admission Committee; Committee Member (2020–present)
- PPBS Admission Committee; Alternate Member (2018–2020)
- UB HR search committee member (Kirkwood lab); UB HR search committee member for position Research Technician II (Posting Number: R1800176) in Dr. Kirkwood‘s lab; Member (2018)
- Oral Biology Research Equipment Purchase Committee; Oral Biology Shared Histology Research Equipment Purchase Committee; Member (2017–2020)