Ding Xu PhD
Ding Xu
PhD
Associate Professor
Specialty/Research Focus
Oral Biology
Education and Training:
- Postdoctoral Fellow, Vascular Biology, Inflammation, University of California, San Diego (2011)
- PhD, University of North Carolina (2007)
- BS, Biochemistry, Central China Normal Universtiy (1999)
Employment:
- Assistant Project Scientist, Cellular and Molecular Medicine, University of California, San Diego, School of Medicine (2011–2014)
Awards and Honors:
- ASBMR 2019 Annual Meeting Research Team Travel Award (2019)
- JBC/Herbert Tabor Young Investigator Award (2012)
- Outstanding Poster Award at the Gordon Research Conference, Proteoglycans (2012)
- The ASBMB 2012 Thematic Best Poster in Glycobiology, 2012 ASBMB Annual Meeting (2012)
- American Heart Association postdoctoral Fellowship (2008)
- American Heart Association Predoctoral Fellowship (2005)
Research Expertise:
- Bone biology
- Glycobiology
- Heparan Sulfate
- Inflammation
- Structural Biology
- www.xulab-heparan.org: Lab website
Grants and Sponsored Research:
- January 2022–December 2022
UB CTSI Translational Pilot Studies Program Grant
NIH/NCATS
Role: Co-Investigator
$46,500 - September 2018–June 2022
In vitro Synthesis of Recombinant Heparan Sulfate
NIH
Role: Co-Principal Investigator
$478,500 - August 2017–June 2022
Heparan Sulfate–Osteoprotegerin Interactions in Bone Remodeling
NIH-NIAMS
Role: Principal Investigator
$1,748,745 - September 2020–August 2021
Antibody-based therapeutic to target RAGE
Buffalo Innovation Accelerator Fund
Role: Principal Investigator
$90,000 - January 2013–December 2014
RAGE – Heparan Sulfate Interactions in Vascular Inflammation
American Heart Association
Role: Principal Investigator
$140,000
Patents:
- Sulfated oligosaccharides decrease sterile inflammation damage in the live A new sulfated heparin sulfate oligosaccharide displays protective effect on drug-induced liver damage. The compound likely inhibits the function of HMGB1, a common protein in regulating immune responses. This discovery can be applied for a wide range of diseases that are caused by over reaction of inflammation responses.
Journal Articles:
- Miaomiao Li, Ding Xu. Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site Proc Natl Acad Sci U S A. 2020.
- Arnold K, Xu Y, Sparkenbaugh EM, Li M, Han X, Zhang X, Xia K, Piegore M, Zhang F, Zhang X, Henderson M, Pagadala V, Su G, Tan L, Park PW, Stravitz RT, Key NS, Linhardt RJ, Pawlinski R, Xu D, Liu J. Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure. Sci Transl Med. 2020; 12(535).
- Zhang X, Ong C, Su G, Liu J, Xu D. Characterization and Engineering of S100A12-Heparan sulfate interactions. Glycobiology. 2020.
- Xiao Y, Li M, Larocque R, Zhang F, Malhotra A, Chen J, Linhardt RJ, Konermann L, Xu D. Dimerization Interface of Osteoprotegerin Revealed by Hydrogen-deuterium Exchange Mass Spectrometry. J Biol Chem. 2018.
- Li M, Yang S, Xu D. Heparan Sulfate Regulates the Structure and Function of Osteoprotegerin in Osteoclastogenesis. J Biol Chem. 2016; 291(46).
- Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013; 8(7).
- Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012; 120(8).
- Xu D, Young J, Song D, Esko JD. Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J Biol Chem. 2011; 286(48).
- Xu D, Fuster MM, Lawrence R, Esko JD. Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 2011; 286(1).
- Settem RP, Honma K, Shankar M, Li M, LaMonte M, Xu D, Genco RJ, Browne RW, Sharma A. Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes. Mol Oral Microbiol. 2018; 33(4).
- Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity Infection and immunity. 2015; 83(9).
- Ryan J. Weiss , Philip L. S. M. Gordts , Dzung Le , Ding Xu , Jeffrey D. Esko and Yitzhak Tor. Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions Chemical Science. 2015; 6.
- Thacker BE, Xu D, Lawrence R, Esko JD. Heparan sulfate 3-O-sulfation: a rare modification in search of a function. Matrix Biol. 2014; 35.
- Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011; 355(2).
- Chang YC, Wang Z, Flax LA, Xu D, Esko JD, Nizet V, Baron MJ. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog. 2011; 7(6).
- Xu D, Esko JD. A Golgi-on-a-chip for glycan synthesis. Nat Chem Biol. 2009; 5(9).
- Xu D, Moon AF, Song D, Pedersen LC, Liu J. Engineering sulfotransferases to modify heparan sulfate. Nat Chem Biol. 2008; 4(3).
- Lu D, Garcia-Contreras L, Xu D, Kurtz SL, Liu J, Braunstein M, McMurray DN, Hickey AJ. Poly (lactide-co-glycolide) microspheres in respirable sizes enhance an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen 85B. Pharm Res. 2007; 24(10).
- Xu D, Song D, Pedersen LC, Liu J. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. J Biol Chem. 2007; 282(11).
- Tiwari V, Clement C, Xu D, Valyi-Nagy T, Yue BY, Liu J, Shukla D. Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts. J Virol. 2006; 80(18).
- Muñoz E, Xu D, Kemp M, Zhang F, Liu J, Linhardt RJ. Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate. Biochemistry. 2006; 45(16).
Professional Memberships:
- American Society for Biochemistry and Molecular Biology (2012–present)
- Society for Glycobiology (2009–present)
- American Society for Matrix Biology (2008–present)
- American Heart Association (2004–present)
Presentations:
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling and inflammation" (2018)
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
- "Heparan sulfate in bone remodeling" (AADR) Buffalo Section, Lunch and Learn Seminar Series, University at Buffalo (2015)
- "Heparan sulfate in inflammation and bone remodeling" Inviated talk, Roswell Park Cancer Institute (2015)
- "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Vasculata 2013, North American Vascular Biology Organization (2013)
- "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Gordon Research Conference, Glycobiology, Gordon Research Conference (2013)
- "Heparan Sulfate–Dependent Oligomerization of RAGE–a novel target for therapeutic intervention" Invited presentation, School of Pharmacy, University of Arizona (2013)
- "Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice" 2012 ASBMB Annual Meeting, ASBMB (2012)
- "Heparan Sulfate as a regulator of VEGF-induced vascular permeability" Gordon Research Conference, Vascular Cell Biology, Vascular Cell Biology (2009)
Service Activities:
- Jacobs School of Medicine & Biomedical Sciences Admissions Committee; Member (2017–2019)
- Oral Biology, School of Dental Medicine Graduate Committee, Thesis; Member (2017–2020)
- Oral Biology, School of Dental Medicine Graduate Committee, Admissions; Member (2017–2019)
- Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Fellow (2017–2018)
- School of Dental Medicine Student Research and Honors Committee; Member (2017–2019)
- Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Advisor (2016)
- Oral Biology, School of Dental Medicine Graduate Committee, Preliminary Exams; Member (2015–2018)