Elaine M. Haase  PhD

Department of Oral Biology

Research Associate Professor

Specialty/Research Focus

Microbiology; Oral Biology

Faculty Research Profile

 
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Professional Summary:

I began my career as a general Medical Technologist and eventually specialized in clinical bacteriology in local hospital. I returned to school to earn an MS in Medical Technology specializing in Microbiology. I continued to work weekends in the hospital while working as a research technician in immunodermatology. I pursued further graduate work and earned a PhD degree in Microbiology from UB. During my thesis work I became interested in molecular mechanisms of infectious disease. As a post-doc I focused on characterizing the genes of the fimbrial operon and biofilm formation by the periodontopathogen Aggregatibacter actinomycetemcomitans. Currently I am working on gene regulation in A. actinomycetemcomitans by small non-coding sRNA. We have recently used RNAseq investigate the effect of amylase on Streptococcus gordonii and DNAseq to explore the phylogeny of amylase-binding proteins in the same bacteria.

Education and Training:
  • PhD, Microbiology, University at Buffalo (1995)
  • MS, Medical Technology, Microbiology Specialty, University at Buffalo (1984)
  • BS, Medical Technology, University at Buffalo (1975)
Employment:
  • Research Associate Professor, Oral Biology, State University of New York at Buffalo (2005-present)
  • Research Assistant Professor, Oral Biology, State University of New York at Buffalo (1998-2005)
  • Post Doctoral Fellow, Oral Biology, State University of New York at Buffalo (1994-1998)
  • Research Assistant, Oral Biology, State University of New York at Buffalo (1994)
  • Research Assistant, Microbiology and Immunology, State University of New York at Buffalo (1986-1994)
  • Research Technician, Microbiology and Immunology, State University of New York at Buffalo (1985-1986)
  • St. Mary‘s Hospital (1975-1991)
Awards and Honors:
  • Listed in Who's Who in America (2010)
  • American Society for Microbiology Student Travel Award (1994)
  • Listed in Who's Who Among Students in American Universities and Colleges (1992)
  • American Society for Microbiology Student Travel Award (1990)
  • Erwin Neter Award from WNY American Society of Microbiology (1990)

Research Expertise:
  • Microbiologist: Bacterial adhesion mechanisms, biofilm studies, protein analylsis, regulation of biofilms, and molecular biology.
  • Bioinformatics: Analysis of RNA-seq and DNA-seq data.
Grants and Sponsored Research:
  • April 2012-March 2017
    Amylase Binding and Gene Expression in S. gordonii.
    NIH-NIDCR
    Role: Co-Investigator
    $1,250,000.00
  • July 2004-June 2007
    Oral Health and Ventilator-Associated Pneumoniae
    NIH, USPHS
    Role: Co-Investigator
    $1,140,607.00
  • July 2004-January 2007
    New Salicylanilides to Treat Oral Diseases
    NIH/SBIR
    Role: Co-Investigator
  • April 2004-December 2008
    Amylase-Binding Streptococci, Dental Plaque and Caries
    NIH, USPHS
    Role: Co-Investigator
    $1,532,810.00
  • January 2002-December 2003
    Studies of the flp operon in A. actinomycetemcomitans
    National Institute for Dental & Craniofacial Research
    Role: Principal Investigator
    $100,000.00

Journal Articles:
See All (32 Total) >

Abstracts:
  • Reardon, J., Haase, E.M., Bronson, P. and Scannapieco, F.A.. AbpA as a Potential Salivary Amylase Inhibitor. IADR 2015. 2015.
  • Varanat, M., Haase E.M. and Scannapieco, F.A.. Involvement of TREM-1 in innate immunity to periodontal bacteria. ASM 115th General Meeting. 2015.
  • Pan, J., Haase, E.M., Vickerman, M.M. and Scannapieco, F.A.. Construction and Characterization of a Non-polar Amylase-binding Protein A (AbpA) Mutant of Streptococcus gordonii. Dental Research Day. 2015.
  • Stuart, W., Haase, E.M. and Scannapieco, F.A.. Leukotoxin secretion and beta-hemolysis in Aggregatibacter actinomycetemcomitans. Dental Research Day. 2014.
  • Reardon, J., Haase, E.M., and Scannapieco, F.A.. AbpA as a potential salivary amylase inhibitor. Dental Student Research Day. 2013.
  • Maddi, A, Haase EM, Scannapieco FA. Proteomic analysis of amylase and of an amylase-binding-protein A interactive components in Streptococcus gordonii. IADR 91st Meeting. 2013.
  • Feng, X, Haase EM, Scannapieco FA. The transcriptional changes of Streptococcus gordonii amylase-binding protein A (abpA-) mutant in TSBY medium. 50th Anniversary Oral Biology Symposium. 2013.
  • Kuo, Y, Haase EM, Scannapieco FA. Identification and protein sequencing of amylase-binding proteins from oral streptococcal species. 50th Anniversary Oral Biology Symposium. 2013.
  • Haase EM, Amarasinghe JA, Scannapieco FA. Novel Fur and iron-regulated small regulatory RNAs of Aggregatibacter actinomycetemcomitans. J Dent Res. 2012.
  • Haase EM. Starch and salivary alpha-amylase induce expression of Streptococcus gordonii AbpA. J Dent Res. 2012.
  • Hei S, Choi K, Kazim LA, Haase EM, Reddy M, Scannapieco FA, and Ruhl SH. Binding between human salivary components and Staphylococcus aureus. J Dent Res. 2012.
  • Violante T, Haase EM, Cianco SG, and Vickerman MM. Effects of antiseptics on Streptococcus gordonii biofilms. J Dent Res. 2012.
  • Nikitkova, A., Haase, E.M., Gill, S.R., Vickerman, M.M., and Scannapieco, F.A.. Roles of salivary amylase and AbpA in Streptococcus gordonii gene expression and host adaptation. ASM 111th General Meeting. 2011.
  • Eidt A, Lee DH, Heo SM, Haase EM, Reischl U, Cisar JO, Scannapieco FA, Ruhl S. Coadhesion Partners for Helicobacter pylori Among Oral Biofilm Microbiota. J Dent Res. 2010; 89.
  • Heo, S-M., Choi, K.S., Kazam, A.L., Reddy, M.S., Haase, E.M., Scannapieco, F.A., and Ruhl, S.H.. Characterization of human salivary components associated with Staphylococcus aureus. J Dent Res. 2010.
  • Amarasinghe, JJ, Scannapieco, FA and Haase, EM. Characterization of Novel Fur- and Iron-regulated sRNA Regulatory Mechanisms Involved in Biofilm Formation of Aggregatibacter actinomycetemcomitans. ASM 109th General Meeting. 2009.
  • Dosen J, Bank TL, Haase EM, Sojar H, Geise RF. Adhesion of Aggregatibacter actinomycetemcomitans (Aa) Flp1 fimbriae to surfaces with different thermodynamic properties. 2nd Annual AFM BioMed Conference. 2008.
  • Amarasinghe JJ, Scannapieco FA, Haase EM. Novel Iron-Regulated sRNAs Involved in Biofilm Formation of Aggregatibacter actinomycetemcomitans.. J Dent Res. 2008; 87.
  • Heo S-M, Haase EM, Scannapieco FA. Genetic Relationship Between Respiratory Pathogens Isolated from the Mouth and Lung.. J Dent Res. 2008; 87.
  • Haase EM, Dunn J, Evans R, Scannapieco FA. Evaluation of Antimicrobial Efficacy Against Biofilms Using the Calgary Biofilm Device.. 4th ASM Conference on Biofilms. 2007.
  • Heo S-M, Haase EM, Scannapieco F. Molecular Epidemiology of Plaque and Lung Bacteria from Ventilated Patients.. J Dent Res. 2007; 86.
  • Amarasinghe JJ, Haase EM, Scannapieco FA. Comparison of Transcription and Translation of Biofilm Determinants of Aggregatibacter actinomycetemcomitans in Response to Environmental Changes. ASM 107th General Meeting. 2007.
  • Amarasinghe JJ, Haase EM, Scannapieco FA. Environmental influences on biofilm determinant expression in Actinobacillus actinomycetemcomitans.. ASM 106th General Meeting. 2006.
  • Haase EM, Bonstein T, Palmer RJ Jr, Scannapieco FA. Heterogeneity of Biofilm Formation Among Strains of Actinobacillus actinomycetemcomitans.. ASM 105th General Meeting. 2005.
  • Haase EM, Legler R, Bonstein T, Bush PJ, Scannapieco FA. An in vitro model assessing tooth whitening agent effectiveness.. J Dent Res. 2004; 83.
  • Haase EM, Collins JM, Wang Y, Chen C, Scannapieco FA. Characterization of selected mutants of the flp operon of Actinobacillus actinomycetemcomitans.. J Dent Res. 2003; 82.
  • Paju S, Haase EM, Tanzer JM, Scannapieco FA. Prevalence of the Gene Encoding Amylase-Binding Protein B, a Putative Peptidase, in Oral Streptococci.. J Dent Res. 2003; 82.
  • Haase EM, Palmer RJ Jr, Wang Y, Chen C, Kolenbrander P, Scannapieco FA. Localization of the rough colony protein A (RcpA) of Actinobacillus actinomycetemcomitans by immunofluorescence.. J Dent Res. 2002; 81.
  • Paju S, Bernstein JM, Haase EM, Scannapieco FA. Non-Cultivable Oral Bacterial Flora of Chronically Inflamed Maxillary Sinuses.. J Dent Res. 2002; 81.
  • Haase EM, Stream JO, Scannapieco FA. Transcriptional Analysis of the 5‘-Terminus of the flp Fimbrial Gene Cluster of Actinobacillus actinomycetemcomitans.. ASM 101st General Meeting. 2001.
  • Haase EM, Scannapieco FA. RNA Analysis of Rough-Colony-Specific Outer Membrane Proteins of Actinobacillus actinomycetemcomitans.. J Dent Res. 2000; 79.
  • Haase EM, Zmuda JL, Scannapieco FA. Identification of Rough-Colony-Phenotype Specific Proteins of Actinobacillus actinomycetemcomitans.. J Dent Res. 1999; 78.
  • Tanzer JM, Baranowski LK, Scannapieco FA, Rogers J, Haase EM. Streptococcus gordonii Colonizes TAN:SPFOM(OM)BR Rats and is Cariogenic with Sucrose.. J Dent Res. 1998; 77.
  • Sanjun IS, Steinhorn DM, Haase EM, Scannapieco FA. Perfluorocarbons Decrease Bacterial Adhesion to Epithelial Cells.. Ped Res. 1998; 43(S2).
  • Haase EM, Rogers JD, Scannapieco FA. Protein Characterization of an Amylase-Binding Deficient Mutant of Streptococcus gordonii.. ASM 97th General Meeting. 1997.
  • Haase EM, Scannapieco FA. Molecular Cloning of a Putative Amylase-Binding Component from Streptococcus gordonii G9B.. J Dent Res. 1996; 75.
  • Rogers JD, Cranston B, Haase EM, Scannapieco FA. Characterization of an Amylase-Binding Deficient Mutant of Streptococcus gordonii Challis.. J Dent Res. 1996; 75.
  • Haase EM, Yi KC, Morse GD, Murphy TF. Mapping of Bactericidal Epitopes on the P2 Porin of Nontypeable Haemophilus influenzae.. ASM 94th General Meeting. 1994.
  • Haase EM, Murphy TF. Monoclonal Antibody Analysis of P2, the Major Outer Membrane Protein of Nontypeable Haemophilus influenzae.. ASM 90th General Meeting. 1990.
  • Klingman KL, Haase EM, Murphy TF. Nearest Neighbor Analysis of Outer Membrane Protein of Nontypeable Haemophilus influenzae.. ASM 88th General Meeting. 1988.
See All (40 Total) >
Professional Memberships:
  • American Dental Education Association Professional Membership (2006)
  • International/American Association for Dental Research Professional Membership. (1996)
  • American Society for Microbiology Professional Membership (1988)
  • American Society for Clinical Pathologists (1975-2001)
Presentations:
  • Transcriptional changes of Streptococcus gordonii amylase-binding protein (abpA) mutant in TSBY medium, Gordon Conference, Salve Regina University (2013)
  • Studies of the Flp Locus of Actinobacillus actinomycetemcomitans, Seminar Series, University of Southern California (2003)
Service Activities:

  • St. Christopher Church, Religious Education; Office assistant for religious education classes. Assist in attendance, answering phone, and other needed tasks. Volunteer at annual Summerfest celebration.; Volunteer (2002)
  • Western New York American Society for Microbiology; Current member of the WNY ASM executive committee. Served as Secretary-Treasurer for 3 years, president-elect 1 year, president 1 year, past president for 3 years.; Committee Member (2000)
  • Laboratory Assistant; Laboratory Assistant for the summer program for Ernest Witebsky Center for Immunology.; Volunteer (1988-1988)

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Contact Information

Foster Hall
Room 109B
3435 Main Street
Buffalo, NY 14214
Phone: (716) 829-2520
Fax: (716) 829-3942
Email: haase@buffalo.edu


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