Mira Edgerton  PhD, DDS

Department of Oral Biology

Research Professor

Specialty/Research Focus

Oral Biology; Prosthodontics

Faculty Research Profile

 
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Education and Training:
  • PhD, Oral Biology, SUNY Buffalo (1994)
  • MS, Oral Sciences, SUNY Buffalo, School of Dental Medicine (1984)
  • Cert, Maxillofacial Pros., Roswell Park Memorial Institute (1982)
  • Cert, Prosthodontics, SUNY Buffalo School of Dental Medicine (1981)
  • DDS, Dentistry, CWRU, Dental School (1979)
  • BS, Biochemistry, Ohio State University (1975)
Employment:
  • Research Professor, Oral Biology, State University of New York at Buffalo (2008-present)
  • Private Practice limited to Prosthodontics (1983-present)
  • Research Professor, Restorative Dentistry, State University of New York at Buffalo (2006-2008)
  • Research Associate Professor, Restorative Dentistry, State University of New York at Buffalo (2001-2006)
  • Clinical Assistant Professor, Restorative Dentistry, State University of New York at Buffalo (1994-2001)
  • Clinical Assistant Professor, Oral Biology, State University of New York at Buffalo (1994-2001)
  • Staff Maxillofacial Prosthodontist, Department of Dentistry, Sisters of Charity Hospital (1983-1985)
  • Clinical Instructor, Removable Prosthodontics, State University of New York at Buffalo (1982-1994)
Awards and Honors:
  • University at Buffalo Top 100 Federal Grantee Award (2002)
  • AADR Student Research Fellowship Award (2002)
  • USPHS Independent Scientist Award (1999)
  • Omicron Kappa Upsilon (1998)
  • Certificate of Teaching Excellence (1984)

Research Expertise:
  • Antifungal Peptides
  • Molecular Mycology
  • Oral Candidiasis
Grants and Sponsored Research:
  • September 2004-March 2009
    Candidacidal Mechanisms of Salivary Histatins - 2004
    NIDCR
    Role: Principal Investigator
    $1,718,695.00
  • August 2003-July 2008
    Comprehensive Training for Oral Health Scientists
    USPHS-NIH
    Role: Co-Investigator
    $2,030,895.00
  • April 2001-March 2005
    Supplements to Support Candida DNA Microarray Facilities
    NIDCR
    Role: Principal Investigator
    $350,000.00
  • April 2000-March 2005
    Candidacidal Mechanisms of Salivary Histatins - 2000
    NIDCR
    Role: Principal Investigator
    $918,060.00
  • June 1999-May 2000
    Controlled release of antimicrobial protiens from oral-based sol-gel monoliths
    SUNY Multidisciplinary Research Pilot Project
    Role: Principal Investigator
    $19,500.00
  • February 1999-January 2004
    Histatin receptors as targets for oral candidiasis
    Independent Scientist Award
    Role: Principal Investigator
    $426,125.00
  • December 1996-December 2000
    Histatin receptors as drug targets for oral candidiasis
    NIH/NIDCR
    Role: Principal Investigator
    $536,899.00
  • July 1996-June 2001
    Training in Fundamental and Applied Oral Health Research
    NIH
    Role: Co-Investigator
    $320,128.00
  • July 1996-July 2001
    DDS/PhD Combined Training Program
    NIDCR
    Role: Co-Investigator
    $844,875.00
  • March 1994-March 1999
    Candidacidal Mechanisms of Salivary Histatins-1994
    NIH/NIDR
    Role: Principal Investigator
    $522,544.00
  • September 1991-October 1992
    Salivary Conditioning of Dental Acrylic
    NIDR Small Grant Program
    Role: Principal Investigator
    $20,556.00
  • April 1987-September 1993
    The Oral Ecology of Prosthetic Surfaces
    NIH/NIDR
    Role: Principal Investigator
    $352,523.00
See All (12 Total) >
Patents:
  • Conjugated Peptides with Fungicidal Activity: U.S. provisional patent application filed; (2013)

Journal Articles:
See All (44 Total) >

Abstracts:
  • Tati S, Jang W.S., Edgerton M. Histatin 5 differential binding to surface glucans and mannans among C. albicans and C. glabrata strains does not influence its toxicity. 11th ASM Conference on Candida and Candidiasis. 2012.
  • Li R., Kumar R., Edgerton M. The role of Candida albicans TPO transporters in efflux of Histatin 5. 11th ASM Conference on Candida and Candidiasis. 2012.
  • Kumar R., Conti F., Saraswat D., Bajawa J.S., Li R.A., Edgerton M. Polyamine transporters Dur3 and Dur31 facilitate uptake of antifungal cationic peptide. 11th ASM Conference on Candida and Candidiasis. 2012.
  • Edgerton M. Cleavage of signaling mucin Msb2 is necessary for the activation of Cek1 MAPK pathway and virulence in Candida albicans. 11th Annual Mark Wilson Conference. 2012.
  • Puri S., Kumar R., Chadha S., Tati S., Conti H.R., Cullen P.J., Edgerton M. Cleavage of signaling mucin Msb2 is necessary for the activation of Cek1 MAPK pathway and virulence in Candida albicans. 11th ASM Conference on Candida and Candidiasis. 2012.
  • Gaffen S, Conti F., Freeman H.R., Holland A., Peterson S., Hernandez-Santos A.C., Jang N., Baker OJ, Pandiyan O., Lenardo P., Edgerton M. Th17, Treg and STAT3 signaling in oral mucosal candidiasis: A new paradigm in antifungal immunity. Gordon Conference on Fungal Immunity. 2011.
  • Edgerton M, Jang W.S., Baker OJ, Conti H.R., Freeman A., Holland S., Gaffen S. The salivary antifungal protein Histatin 5 is an innate immune molecule regulated by IL 17. Gordon Conference on Funal Immunity. 2011.
  • Edgerton M, Kumar R., Chadha S., Bajawa J.S., Jang W.S.. Uptake of the antifungal protein Histatin 5 by C albicans is via the native polyamine transproter Dur2p. 10th Annual Mark Wilson Conference. 2011.
  • Bajwa J.S., Kumar R., Chadha S., Jang W.S., Edgerton M. Polyamine transporter Dur3 mediates salivary Histatin 5 uptake. IADR Conference. 2011.
  • Chadha S., Bajwa J.S., Sun J.N., Paluszynski J, Jang W.S., Edgerton M. Spermidine plasma membrane transporter Dur3 is involved in the translocation of Histatin 5 in C. albicans. 10th Candida and Candidiasis Congerence. 2010.
  • Jang W.S., Sun J.N., Edgerton M. Salivary Histatin 5 Internalization by Translocation, but not Endocytosis, kills Candida albicans by Disruption of Intracellular Ionic Balance ASM. 10th Candida and Candidiasis Conference. 2010.
  • Chadha S., Paluszynski J.N., Bajwa J.S., Jang W.S., Edgerton M. C. albicans Msb2 is secreted mucin-like proteins that contributes to adhesion and virulence in oropharyngeal candidiasis. 10th Candida and Candidiasis Conference. 2010.
  • Gaffen S, Conti F., Shen F., Sun J.S., Lindemann M.J., Hai J.H., Masso-Welch P., Edgerton M. Th17/IL-17 receptor signaling and not Th1 cells are essential for host defense against oral candidiasis. 10th Candida and Candidiasis Conference. 2010.
  • Gaffen SL, Conti HR, Shen F, Nayyar N, Stocum E, Sun J, Lindeman M, Ho A, Hai JH, Masso-Welch P, Edgerton M. Th17/IL-17 receptor signaling and not Th1 cells are essential for mucosal host defense against oral candidiasis. Cytokine. 2009; 48(1).
  • Li XS, Sun JN, Edgerton M. Lysine Residues are Required for Histatin Translocation into Candida albicans. J Dent Res. 2007; 86(A).
  • Sun JN, Li XS, Edgerton M. ATP hydrolysis mediates C. albicans ssa2p-Histatin5 complex formation. J Dent Res. 2007; 86(A).
  • Nayaar N, Filler N, Solis N, Sun JN, Edgerton M. Ssa1 proteins are important virulence determinants in Candida albicans. J Dent Res. 2007; 86(A).
  • Okamoto-Shibayama K, Vylkova S, Edgerton M. Microarray analyses of Candida albicans transporter gene expression with Hst 5. J Dent Res. 2007; 86(A).
  • Vylkova S, Sun JN, Edgerton M. Human beta defensins and histatin 5 have overlapping mechanisms of killing of Candida albicans. ASM 160th General Meeting. 2006; F(004).
  • Sun JN, Li XS, Edgerton M. Candida albicans cell wall HSP70 proteins mediate binding with the cationic peptide Histatin 5. 8th ASM Conference on Candida and Candidiasis. 2006; A(166).
  • Vylkova S, Nayyar N, Edgerton M. Human beta defensins kill Candida albicans in a salt-sensitive and energy-dependent manner that does not involve membrane disruption. 8th ASM Conference on Candida and Candidiasis. 2006; C(138).
  • Pusateri C, Vylkova S, Monaco E, Edgerton M. Sensitivity of Candida albicans Biofilm Cells to Histatin 5. J Dent Res. 2006.
  • Sun JN, Vylkova S, Baev D, Edgerton M. Transcriptional and Translational Levels of Candida alvicans TRK1. J Dent Res. 2005; 84(A).
  • Li XS, Baev D, Edgerton M. Candida albicans HSP70 Deletion Reduces Antifungal Activity of Histatin 5. J Dent Res. 2005; 84(A).
  • Vylkova S, Baev D, Edgerton M. Salivary Histatin 5 Targets TRK1 Potassium Transporter in Candida albicans. J Dent Res. 2005; 84(A).
  • Berner JC, Vylkova S, Baev D, Edgerton M. Histatin 5-Induced Propidium Iodide Uptake in Candida albicans is Through TRK1p. J Dent Res. 2005; 84(A).
  • Li XS, Reddy MS, Edgerton M. Candida Albicans heat shock proteins (Ssa) are identified as Histatin binding proteins and mediate fungicidal activity of Histatin 5. J Dent Res. 2003; 82(A).
  • Vylkova S, Baev D, Li XS, Edgerton M. Histatin 5 killing of Candida albicans involves TOK1 potassium channels. J Dent Res. 2003; 82(A).
  • Wunder DE, Edgerton M. Susceptibility of yeast SOD mutants to Histatin 5 treatment. J Dent Res. 2003; 82(A).
  • Li XS, Baev D, Keng PC, Edgerton M. Histatin 5 causes cell size reduction and G0/G1 cell cycle arrest in Candida albicans. J Dent Res. 2002; 81(A235).
  • Wunder DE, Dong J, Baev D, Edgerton M. Generation of reactive oxygen species and chromosomal changes following Hst 5 treatment of Candida albicans. J Dent Res. 2002; 81(A236).
  • Edgerton M, Li X, Baev D, Dong J, Keng P. Histatins cause disordered volume regulation and G0/G1 cell cycle arrest in Candida albicans.. ASM Conference on Candida and Candidiasis. 2002.
  • Edgerton M, Baev D, Li X, Dong J, Keng P. Histatins cause disordered volume regulation and G1 cell cycle arrest in C. albicans. Microbial Pathogenesis and Host Response. 2001.
  • Patel R, Koshlukova S, Araujo MBW, Edgerton M. ATP release is inhibited by increase in (Ca2+) and (MG2+).. J. Dent. Res.. 2000; 79(174).
  • Araujo, MBW, Koshlukova, S, Patel, R, Mira Edgerton. Salivary histatin 5 and Human neutrophil peptide- 1 (NP-1) share a comon candidacidal pathway (HNP-1). J Dent Res. 2000; 79(248).
  • Patel R, Koshlukva S., Lloyd T., Araujo MBW, Edgerton M. Candidacidal actvity of salivary histatins in physiological inorganic buffers.. J Dent Res. 1999; 78(1894).
  • Koshlukova S, Lo T, Chrzan B, Edgerton M. Histatin Interaction with Candida albicans Envelope Protein is Related to Candidacidal Activity. J Dent Res. 1997; 76(2723).
  • Edgerton M, Lo T, Anthony Raj PA. Salivary Histatin 3 and Histatin 5 exhibit secific binding to yeast cell membranes.. J Dent Res. 1996; 75(2723).
  • Gauri, Edgerton M, Anthony Raj P. Bactenecin 5: A potent bactericidal agent for Porhyromonas gingivalis.. J Dent Res. 1996; 75(3289).
  • Lee W, Loza J, Edgerton M, Bryant HU, Turner AS. Effect of Ovariectomy on Mandibular Bone in Ewes.. J Dent Res. 1996; 75(1579).
  • Subramanian P, Edgerton M, Raj PA. Synthesis and candidacidal activity of the fragments of salivary histatin 3 and histatin 5.. J Dent Res. 1995; 74.
  • Edgerton M, Lo S, Scannapieco FA, Levine MJ. Titanium salivary pellicle inhibits adhesion of streptococcal species.. J Dent Res. 1994; 73(2168).
  • Edgerton M, Lo SE, Levine MJ. Histatins induce leakage from C. albicans cells and model liposome membranes.. J Dent Res. 1993; 72.
  • Edgerton M, Levine M, Raj PA. Salivary histatin 5 coated to PMMA retains anticandidal properties.. J Am Soc Microbiol. 1993.
  • Raj PA, Genco RJ, Levine MJ, Edgerton M. Dependence of secondary structure for candidacidal activity of bactenecins and defensins.. J Dent Res. 1993; 72.
  • Edgerton M, Scannapieco FA, Reddy MS, Levine MJ. Candida albicans selectively absorbs salivary mucins.. J Dent Res. 1992; 71.
  • Edgerton M, Bradway SD, Levine MJ. In vitro adhesion of salivary molecules and Candida albicans to PMMA beads.. J Dent Res. 1990; 69(1689).
  • Edgerton M, Yoon KJ, Levine MJ. Comparison of acquired salivary pellicles from denture surfaces.. J Dent Res. 1989; 68(1388).
  • Yoon KJ, Edgerton M, Levine MJ. Binding of Candida albicans to human saliva and acquired pellicles.. J Dent Res. 1989; 68(1389).
  • Edgerton M, Cohen RE, Aguirre A, Reddy M, Levine MJ. Immunochemical Analysis of Human Palatine Salivary Mucins. J Dent Res. 1988; 67.
  • Edgerton M, Cohen RE, Levine MJ. Characterization of human palatine saliva.. J Dent Res. 1987; 66(1225).
  • Edgerton M, Bengtsson CE, Slots J. Clinical and microbiological studies of patients on cancer chemotherapy.. J Dent Res. 1983; 62(1133).
See All (52 Total) >
Books and Book Chapters:
  • Puri S, Edgerton M. Candida albicans Ssa: An Hsp70 homologue and virulence factor. Moonlighting Cell Stres Proteins in Microbial Infections. 2013; 14.
  • Jang WS, Edgerton M. Salivary Histatins: Structure, Function and Mechanisms of Antifungal Activity. Candida and Candidiasis. 2011; 13.
Professional Memberships:
  • FASEB (2002)
  • American Society for Biochemistry and Molecular Biology (2002)
  • National Institute of Dental and Craniofacial Research Study Section, Oral Biology and Medicine 1 (2002-2005)
  • American Association for the Advancement of Science (1999)
  • Academy of Osseointegration (1995)
  • American College of Prosthodontists (1995)
  • American Society of Microbiology (1994)
  • American Association of Women Dentists (1993)
  • Buffalo Association of Women Dentists (1993)
  • University of Buffalo Dental Alumni (1992)
  • Erie County Dental Society (1988)
  • International Association of Dental Research Salivary Research Group, Prosthodontics Group (1981)
  • American Dental Association (1979)
  • New York Dental Society (1979)
  • Eighth District Dental Society (1979)
Presentations:
  • Molecular Mycology: Current Approaches to Fungal Pathogenesis, Marine Biological Laboratory (2007)
  • Is Salivary Histatin a Prototypicl Antifungal Peptide-Hallmarks of Cytotoxicity, Minnesota Craniofacial Research Training (MinnCResT) Program, University of Minnesota (2007)
  • Factors sustaining thematic independent research programs, ACPEF/UNC Prosthodontic Research Symposium, University at North Carolina (2007)
  • Host Defense Strategies: Candidacidal Targets of Histatins, ASM 160th General Meeting Symposium: Antimicrobial Peptides Versus Fungal Pathogens: The Players and the Rules, American Society for Microbiology (2006)
  • Molecular Targets for Histatin 5, ASM 8th Conference on Candida and Candidiasis, Session: Antimicrobial Peptides, American Society for Microbiology (2006)
  • Mechanism of Antifungal Activity of Human Histatins, Gordon Conference on Antimicrobial Peptides (2005)
  • Mechanism of Innate Host Defense Proteins, Second Annual Buffalo Conference on Immunology, Buffalo Conference on Immunology (2002)
  • Histatin 5 causes Disordered Volume Regulation and G1 Cell Cycle Arrest in C. Albicans, Cold Spring Harbor Laboratories, Microbial Pathogenesis and Host Defense (2001)
  • Molecular Biology Section, Panel Presenter, University at Buffalo NIH Grantsmanship Workshop, University at Buffalo (2001)
  • Session II: Functions of Saliva, 16th International Conference on Oral Biology (2000)
  • "Salivary Antimicrobials" in Saliva in Health and Disease, Scientific Program 16th International Conference on Oral Biology (2000)
  • Salivary antimicrobial proteins:their role in oropharyngeal host defense, Latin American-U.S. Conference on Salivary Research, Latin American Association for Salivary Research (1999)
  • Oral Candidal Infections and Future Therapeutic Modalities, The American College of Prosthodontists (1996)
  • Salivary Proteins II: Cloning and Functional Studies, IADR Salivary Research Group-Session (1996)
  • Fixed and Removable Prosthetic Restoration of Endosseous Implants, Jamestown-Warren Dental Implant Study Club (1996)
  • Periodontal Pathogens Associated with Dental Implants, IADR Implantology Research Group-Session (1994)
  • Application of Basic Knowledge in Wound Healing to Enhance Biocompatibility, Academy of Prosthodontics (1993)
  • Research in Biological Technologies which may be transferred to Prosthodontics, Academy of Denture Prosthetics, 72nd Annual Meeting, Academy of Denture Prosthetics (1991)
  • Regulation of Microbial Adherence at the Salivary Prosthetic Interface, Academy of Denture Prosthetics, 72nd Annual Meeting, Academy of Denture Prosthetics (1990)
  • Dental Implants, Niagara County Dental Society (1989)
  • The Interaction of Saliva and Prosthodontics, 18th Annual James A. English Symposium (1988)
  • Osseointegrated Implants, Buffalo Association of Women Dentists (1988)
  • Maxillofacial Prosthetics - The Mandibulectomy Patient, SUNY Buffalo Association for Student Research (1985)
  • Prosthetic Treatment of the Cleft Palate Patient from Birth to Adulthood, Buffalo Association of Speech Pathologists (1984)
  • Specialized Removable Partial Dentures:Swinglock, Overlay, and Lingual Band Partial Denture, Association of Women Dentists (1984)
  • Esthetics-The Contriibution of Removable Prosthodontics, Metropolitan Dental Study Club (1984)
  • Removable Prosthodontics-Special Considerations for the Class II and Class III Patient, Chautauqua County Dental Society (1983)
  • Improving Facial Contours Through Removable Prosthodontics, Table Clinic-Greater Niagara Frontier Dental Meeting, Greater Niagara Frontier Dental (1983)
  • Oral Complications and Microbiological Changes Following Cancer Chemotherapy, Symposium on Oral Complications of Cancer Chemotherapy, Harvard Medical School (1983)
  • The Transitional Denture: Its Indications and Uses, Table Clinic-Greater Niagara Frontier Dental Meeting, Greater Niagara Frontier Dental (1982)
  • The Removable Partial Overdenture, Table Clinic-Greater Niagara Frontier Dental Meeting, Greater Niagara Frontier Dental (1980)
See All (31 Total) >
Service Activities:
  • School of Dental Medicine Graduate Committee, Admissions, Oral Biology; Chair (2008)
  • School of Dental Medicine Graduate Committee, D.D.S./Ph.D., Oral Biology; Chair (2008)
  • School of Dental Medicine Student Research and Honors Committee; Co-Chair (2008)
  • School of Medicine & Biomedical Sciences Admissions Committee; Member (2002-2006)
  • School of Dental Medicine Search Committee; Chair (2002-2002)
  • School of Dental Medicine Student Research and Honors Committee; Member (1996)
  • School of Dental Medicine Student Research and Honors Committee; Member (1991-1992)

  • Salivary Research Group, IADR/AADR; President (2005-2006)
  • Judge for Poster Session; Gordon Conference on Salivary Glands and Exocrine Secretions; Judge (2005-2005)
  • Erie County Dental Society Board of Directors; Board of Directors (2005)
  • Antimicrobial Agents Chemotherapy; Editorial Board Member (2005-2010)
  • Erie County Dental Society; Past President (2004-2004)
  • Erie County Dental Society; President (2003-2003)
  • Erie County Dental Society; Vice President (2002-2002)
  • Journal of Dental Research; Editorial Board Member (2002-2004)
  • Erie County Dental Society; Secretary (2000-2001)
  • NIDCR Workshop on Development of New Technologies for Saliva and other ....; Working Group Moderator: Unique Aspects of Oral Fluids for Diagnostics; Member (1999-1999)
  • Task Force to Review the Definition of the Specialty Amer Coll of Prosthodontists; Member (1999-1999)
  • Erie County Dental Society Board of Directors; Chair Program Committee; Chair (1997-1999)
  • International Journal of Oral and Maxillofacial Implants Review Board; Board Member (1996-1999)
  • Antimicrobial Agents Chemotherapy; Ad Hoc Reviewer (1995)
  • Applied and Environmental Microbiology; Ad Hoc Reviewer (1995)
  • Archives Oral Biology; Ad Hoc Reviewer (1995)
  • Biochemical Journal; Ad Hoc Reviewer (1995)
  • Biochimica et Biophysica Acta; Ad Hoc Reviewer (1995)
  • BMC Microbiology; Ad Hoc Reviewer (1995)
  • Cellular Microbiology; Ad Hoc Reviewer (1995)
  • Cellular and Molecular Life Sciences; Ad Hoc Reviewer (1995)
  • Clinical and Diagnostic Laboratory Immunology; Ad Hoc Reviewer (1995)
  • Current Genetics; Ad Hoc Reviewer (1995)
  • Eukaryotic Cell; Ad Hoc Reviewer (1995)
  • European Journal of Oral Sciences; Ad Hoc Reviewer (1995)
  • Genetics; Ad Hoc Reviewer (1995)
  • Immunology and Cell Biology; Ad Hoc Reviewer (1995)
  • Journal of Anticicrobial Chemotherapy; Ad Hoc Reviewer (1995)
  • Journal of Biological Chemistry; Ad Hoc Reviewer (1995)
  • Journal of Clinical Microbiology; Ad Hoc Reviewer (1995)
  • Journal of Periodontology; Ad Hoc Reviewer (1995)
  • Infection and Immunity; Ad Hoc Reviewer (1995)
  • Microbial Ecology in Health and Disease; Ad Hoc Reviewer (1995)
  • Microbiology; Ad Hoc Reviewer (1995)
  • Molecular and Cellular Biochemistry; Ad Hoc Reviewer (1995)
  • Molecular Genetics and Genomics; Ad Hoc Reviewer (1995)
  • Molecular Microbiology; Ad Hoc Reviewer (1995)
  • Proceedings of theNational Academy of Sciences (PNAS); Ad Hoc Reviewer (1995)
  • Yeast; Ad Hoc Reviewer (1995)
  • Editorial Review Board; Journal of Prosthetic Dentistry; Ad Hoc Reviewer (1992-2001)
  • Journal of Prosthetic Dentistry; Editorial Board Member (1992-2001)
  • AADR/IADR; Reviewer for IADR absracts; Prosthodontics Section; Reviewer (1992-1994)
  • SUNY Buffalo Dental Alumni Association; Chairman, Publications Committee; Chair (1984-1986)
  • Erie County Dental Society, Committee on Dental Laboratory Trade Relations; Committee Member (1982-1982)
See All (51 Total) >

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Contact Information

310 Foster Hall
Buffalo, NY 14214
Phone: (716) 829-3067
Fax: (716) 829-3942
Email: edgerto@buffalo.edu


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