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 ResearchResearch AreasRelationship of Oral Pathogens to Systemic DiseaseSchifferle     December 21, 2014  

Relationship of Oral Pathogens to Systemic Diseases

ROBERT SCHIFFERLE, MA, DDS, MMSc, PhD personal profile

Focus on polysaccharide and lipopolysaccharide of Porphyromonas gingivalis

Bacterial virulence may be enhanced by the presence of a polysaccharide capsule or by lipopolysaccharide. The polysaccharide capsules often act to inhibit phagocytosis, allowing for evasion of host defense mechanisms.

Our laboratory is engaged in the study of polysaccharide and lipoplysaccharide of P. gingivalis. Polysaccharide and lipopolysaccharide are released from the bacterial cell surface and purified by a variety of techniques. The purified components are then characterized chemically and immunologically. The ability of these components to function as immunogens and as activators of the serum complement system is under investigation. Current investigations are also evaluating the association to periodontal disease and the capsular polysaccharide serotype.