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 ResearchResearch AreasBone and Connective Tissues/Tissue EngineeringYang     July 22, 2014  

Bone and Connective Tissues/Tissue Engineering

SHUYING (SHERI) YANG, MD, PhD  personal profile

Mechanism of bone resorpton and bone formation; gene therapy and stem cell mediated periodontal and craniofacial bone regeneration

Most adult skeletal diseases are due to excess osteoclastic activity, leading to an imbalance in bone remodeling which favors resorption. Such diseases would include osteoporosis, periodontal disease, rheumatoid arthritis, multiple myeloma and metastatic cancers. Therefore, understanding the molecular mechanisms of osteoclast and osteoblast differentiation and activation is critical for successful treatment of these diseases. My current research efforts focus on identifying the role and mechanism of novel or known genes in bone-related signal pathways and understanding how these genes regulate bone formation and bone resorption by using gene knockout technology. We are also working on gene therapy and stem cell mediated periodontal and craniofacial bone regeneration.

Another area of Dr. Yang's research is available at Immunology and Innate Defenses