University at Buffalo - The State University of New York
Skip to Content
The Clinical Proteomic Technologies for Cancer | Details for Peroxiredoxin 2 Peptide 2

Peroxiredoxin 2 Peptide 2


Background

Catalog Number:

CPTC-PRDX2-2

Target Antigen:

Peroxiredoxin 2 Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/01/2015

Antigen Recognition(s):

Purchase
Characterization Data [Compare Characterization Data]
  Western Blot
Click to enlarge image Western Blot using CPTC-PRDX2-2 as primary Ab against full-length recombinant Ag 10333 (lane 2). Also included are molecular wt. standards (lane 1) and the PRDX2-2 Ab as positive control (lane 3). Click image to enlarge

CPTC-PRDX2-2 Western blot

Western Blot using CPTC-PRDX2-2 as primary Ab against full-length recombinant Ag 10333 (lane 2). Also included are molecular wt. standards (lane 1) and the PRDX2-2 Ab as positive control (lane 3).

  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-PRDX2-2 Indirect ELISA (peptide)

Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.

Characterization SOP Files

Background

NCI Identification Number:

00044

Antigen Name:

Peroxiredoxin 2 Peptide 2

CPTC Name:

CPTC-PRDX2 Peptide 2

Keywords:

NKEFB; PRP; TDPX1; TSA; PRX2; PRXII; Natural Killer Cell-Enhancing Factor B; Thioredoxin-Dependent Peroxide Reductase 1; NKEF-B; EC 1.11.1.15; MGC4104; PTX1; TPX1; Peroxiredoxin-2; Thiol-Specific Antioxidant 1; Torin; EC 1.11.1

Function:

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Chromosomal Localization:

19p13.2

Expression System:

NCBI Accession Number:

NP_005800.3

Swiss Prot Accession Number:

P32119

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

GLFIIDGK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

880

Last Updated:

06/21/2013

Links

Characterization Data

SOPs

No SOPs available.

Don't have Adobe Reader™?

Get it for free at Adobe.com