A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1

K Gaus, JJ Gooding, RT Dean, L Kritharides… - Biochemistry, 2001 - ACS Publications
The kinetics (0 to 3 h) of cholesterol efflux to delipidated apolipoprotein A-1 were
investigated, and the experimental data were best fitted to a mathematical model that
involves two independent pathways of cholesterol efflux. The first pathway with a rate
constant of 4.6 h-1 is fast but removes only 3− 5% of total cholesterol. After preconditioning
apoA-1, it was found that this pathway remains, and hence it is a property of the ...