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Modulation of Immune Responses Induced by DNA Vaccine Expressing Glycoprotein B of Pseudorabies Virus via Coadministration of IFN-γ-Associated Cytokines | Abstract Skip Navigation
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Journal of Interferon & Cytokine Research

Modulation of Immune Responses Induced by DNA Vaccine Expressing Glycoprotein B of Pseudorabies Virus via Coadministration of IFN-γ-Associated Cytokines

To cite this article:
Hyun A. Yoon, Abi G. Aleyas, Junu A. George, Seong Ok Park, Young Woo Han, John Hwa Lee, Ho Young Kang, Seong Ho Kang, Jeong Gon Cho, and Dr. Seong Kug Eo. Journal of Interferon & Cytokine Research. October 2006, 26(10): 730-738. https://doi.org/10.1089/jir.2006.26.730

Published in Volume: 26 Issue 10: October 10, 2006

Author information

Hyun A. Yoon
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Abi G. Aleyas
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Junu A. George
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Seong Ok Park
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Young Woo Han
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
John Hwa Lee
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Ho Young Kang
Division of Biological Sciences, College of Natural Sciences, Pusan National University, Pusan 609-735, Republic of Korea.
Seong Ho Kang
Division of Chemistry, College of Natural Sciences, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Jeong Gon Cho
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Dr. Seong Kug Eo
College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.

ABSTRACT

The immunomodulatory efficacy of interferon-γ (IFN-γ)-associated cytokines coadministered with a plasmid DNA vaccine has been investigated, with variable results. Therefore, to test the immunomodulatory effect of IFN-γ-associated cytokines as vaccine adjuvant, the present study evaluated the immune responses induced by pseudorabies virus (PrV) gB-encoded plasmid DNA vaccine coadministered with IFN-γ-associated cytokines and chemokines. These cytokines and chemokines included interleukin-12 (IL-12) and IL-18, as potent inducers of IFN-γ, and IFN-γ-inducible protein (IP-10), the production of which is IFN-γ dependent. A coinjection of either IL-12 or IL-18 strongly suppressed the humoral antibody responses but increased the production of the Th1-type cytokines IFN-γ and IL-2 from immune T cells. Such antibody suppression was closely related to the increased susceptibility against a virulent viral challenge. On the other hand, IP-10 exhibited enhanced immune responses in both antibody responses and IFN-γ production of immune T cells and facilitated the prolonged survival of infected mice. In contrast, there was no significant change in the immune responses of the mice that received codelivery of IFN-γ. Therefore, IFN-γ-associated cytokines, as Th1-type inducers, can generate unexpected and unwanted effects, and their application as a vaccine adjuvant should be carefully evaluated depending on the target antigens.

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