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PubMed Central, Figure 7: Cell Death Differ. 2016 June; 23(6): 1073–1085. Published online 2016 January 15. doi: 10.1038/cdd.2015.162
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Published online 2016 January 15. doi: 10.1038/cdd.2015.162

Figure 7

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Functional interplay between ΔNp63 and immune activation, itch and defects in keratinocyte terminal differentiation in AD. This model depicts the role ΔNp63 plays in directing various components involved in the development of atopic dermatitis. Elevated expression levels of ΔNp63 results in direct activation of IL-33 signaling and subsequent Th2 polarization. Induction of pruritus occurs through direct regulation of IL-31, IL-31ra and OSMR gene expression. Elevated ΔNp63 epidermal expression, scratching response to pruritus and Th2 cell activation all contribute to alterations in keratinocyte terminal differentiation

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