[HTML][HTML] Muc5b is required for airway defense

MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee… - Nature, 2014 - ncbi.nlm.nih.gov
Abstract Respiratory surfaces are exposed to billions of particulates and pathogens daily. A
protective mucus barrier traps and eliminates them via mucociliary clearance (MCC) 1, 2.
However, excessive mucus contributes to transient respiratory infections and to the
pathogenesis of numerous respiratory diseases 1. MUC5AC and MUC5B are evolutionarily
conserved genes that encode structurally related mucin glycoproteins, the principal ...

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