Results of the efficacy and time efficiency of computer-assisted learning (CAL) in endodontics education are mixed in the literature. The objectives of this study were to compare the efficacy and time efficiency of CAL with traditional learning methods or no instruction. The search strategy included electronic and manual searches of randomized controlled trials (RCTs) completed in English up to June 2009. The intervention comprised any method of CAL, while the control group consisted of all traditional methods of instruction including no further instructions. Various outcome measures of CAL efficacy were considered and were categorized using Kirkpatrick's four-level model of evaluation: reaction, learning, behavior, results, with the addition of return on investment as a fifth level. The time efficiency of CAL was measured by the time spent on the learning material and the number of cases covered in a unit period. Seven RCTs met the inclusion criteria. Overall, students' attitudes were varied towards CAL. Results from the knowledge gain outcome were mixed. No conclusions can be made about students' performance on clinical procedures or cost-effectiveness of CAL. Better time efficiency was achieved using CAL compared to traditional methods. CAL is as efficacious as traditional methods in improving knowledge. There is some evidence to suggest that CAL is time efficient compared to traditional methods. Overall, the number of studies included in this review was small, thus warranting the need for more studies in this area and the exploration of various CAL techniques.