Many of the TOXNET databases have information on prescription and nonprescription drugs. There are two starting points that can help you locate the best resource for you.
There are other NLM resources with drug information. These resources are included in searches done in ChemIDplus and the Drug Information Portal:
Corrections can be made if the error is in a PubMed citation found TOXLINE or DART because these databases are produced by NLM. Visit Reporting an Error in PubMed for more information.
If the error is in other parts of TOXLINE, DART or the other TOXNET databases corrections cannot be made because NLM does not produce these databases.
TOXNET does not allow limiting retrieval by age or by types of articles.
TOXLINE and DART retrieval can be limited by author, title, publication year and by language. Use the Advanced Search option. Visit TOXLINE/DART Help for more information on using limits in TOXLINE.
The other TOXNET databases have limits specific to each database. The fields available vary by database. When you click on the Advanced Search tab you will see the fields available for that database. You can use as many or as few fields as desired. If the search term does not appear in those fields, you will get a message that "No records were found".
There are three options for removing PubMed citations from TOXLINE or DART searches:
TOXNET search results are displayed in relevancy ranked order. Relevancy ranking is based on the number of individual search terms in a document, the number of times each search term occurs in a document, the rarity of the search terms within the database, and the nearness of search terms to each other. Records containing combinations of search terms tend to be ranked higher than records with isolated occurrences of search terms.
If you search for only a single chemical in HSDB, CCRIS, IRIS, ITER, GENETOX, LactMed, CPDB, or CTD the primary record will be displayed first. Other records listed will have one or more of the requested chemical name(s) anywhere in the record.
Use the drop down menu labeled "Sort By".
You can print one record at a time. Use the Print icon from within an individual record. In HSDB, CCRIS, IRIS, ITER, GENETOX, LactMed, TRI or CTD you can select which sections you'd like to have printed by displaying those sections before you click the Print icon.
Note: Records in HSDB may be many pages long.
Use the "Download" feature to save the search results as a plain text file. Only records from TOXLINE and DART can be imported into reference management software such as Reference Manager.
"Download" is not available for ChemIDplus, CPDB, CTD, Haz-Map, Household Products Database, and TOXMAP.
You cannot store search strategies in TOXNET. You can use the History feature to retrieve searches recently performed. Search History is lost after one hour of inactivity.
You can also copy and paste your search strategy into a document, save the document, and then later paste the search strategy into the TOXNET search box.
HSDB, TOXLINE, LactMed, DART, TRI, CTD, IRIS, ITER, CCRIS, GENE-TOX: Use the Permalink option found on the upper right of a TOXNET record.
ChemIDplus: Copy the URL found in the address line of the browser you are using
Haz-Map: Copy the URL found in the address line of the
Database: Copy the URL found in the address line of the browser you are using
TOXMAP: Visit How can I link my site to TOXMAP? for directions
There are several ways of getting a full text article:
NIH RePORT Expenditures and Results Tool (RePORTER) in TOXLINE
Government Reports Announcements & Index (GRA&I)
References from TOXLINE and DART can follow either the journal article citation rules in the author instructions for a specific journal or your particular requirements.
The citation format preferred by NLM for databases such as HSDB, IRIS, ITER, GENE-TOX, and CCRIS is shown below.
Format Template: MeSH Browser [Internet]. Bethesda (MD): National Library of Medicine (US); 2001- [updated 2001 Apr 5; cited 2001 Apr 10]. Meta-analysis; unique ID: D015201; [about 3 p.]. Available from: http://www.nlm.nih.gov/mesh/MBrowser.html
Example: Hazardous Substances Data Bank [Internet]. Bethesda (MD): National Library of Medicine (US); [Last Revision Date ????; cited 2011 Mar ]. Potassium Nitrate; Hazardous Substances Databank Number: ???; [about # screens]. Available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Check your local library's catalog to see if the book is available. If the bookis not owned by the library, you can borrow the book from the National Library of Medicine.
To borrow a book from NLM:
Only citations from TOXLINE and DART can be imported into reference management programs, such as ProCite, Reference Manager, and EndNote. Results from HSDB, IRIS, ITER, CCRIS, GENE-TOX, and TRI are in formats that cannot be understood by the software.
To import search results from TOXLINE and DART into a reference management program:
This information will help you find a journal's title but does not link to full text resources.
NLM can give only limited support for those acquiring TOXNET data. If you need information about a field or find an error in the data, please email: firstname.lastname@example.org. Since many of the databases are created by other agencies, some problems cannot be corrected immediately.
Attempting to validate the XML data is a common problem. The TOXNET XML files produce well-formed XML data in accordance with W3C specifications. Validating parsers behave differently. Making XML data work for your application may require the services of a professional text programmer.
Updated datasets are placed on the FTP site by the close of the 28th of each month, Eastern Standard/Daylight Time. Occasional problems with the data or the coincidence of weekends or holidays may delay the data for 1-2 days.
If there is any change in the data from the previous month, the new version will be placed on the site. Please note that some of these changes may be extremely minor.
ChemIDplus is created from more than 100 sources. The core sources of substance records correspond to those substances that are cited in one or more of the National Library of Medicine (NLM) databases.
Other sources include the Canadian Domestic Substances List (DSL), European EINECS, EPA TSCA Inventory, the SUPERLIST set of regulatory resources, and other internet databases such as EPA Substance Registry System, the FDA Drugs@FDA system, IARC, NIAID, and NIST Chemistry WebBook. A full list of Locators can be found here (http://sis.nlm.nih.gov/chem/alllocators.html).
ChemIDplus Lite is designed for simple searching by name or registry number and returns basic information about a chemical and provide links to other resources. Clicking on the Full Record in a ChemIDplus Lite result shows a substance's structures, but does not allow drawing or searching on structures.
ChemIDplus Advanced provides links to the same resources as the Lite version. In addition, it lets users draw their own structures and perform chemical similarity and substructure searches and search by any combination of name, registry number, molecular formula, classification code, locator code, toxicity, physical property, structure, or molecular
Search results done in either ChemIDplus Lite or ChemIDplus Advanced show the name, registry number, molecular formula, classification code, locator code, toxicity, physical property, structure, and molecular weight. For toxicity and physical property data, search terms are highlighted within the Advanced table results.
If you have an older browser select "Marvin applets incl. 3D" from the pull down menu in the Structure area of the page.
When Marvin for Java first loads, you must answer whether to trust it "this time or always". If "always" is selected, it will not ask each session.
Marvin is also used to display structures such as PNG (Portable Network Graphics) files in our results page so that a plug-in is not needed to view results.
The Java applet Marvin requires that the latest version of Java be installed on your computer. If you don't have the latest version you will be prompted to download it. For security reasons, it is recommended that you get the latest version.
Click on the "Draw" button in the "Structure" box in ChemIDplus Advanced to launch the structure editor.
The editor includes chemical drawing tools and help files. Changes you make in MarvinSketch show up immediately in the ChemIDplus Advanced "Structure" box after you hit the "Close" button. You may then select the type of Structure search, add any qualifying data ranges (such as molecular weight), and click on the Search button on the top or bottom of the page.
Chime was a free chemical display application that has been phased out. ChemIDplus no longer supports it. Accelrys Draw - No Fee is a structure drawing package available. You will need to register to download Accelrys Draw - No Fee. You may have difficulties with the applications in Firefox and Chrome.
If Marvin is loaded in your computer click "Transfer Structure to query page" from a search results page. This moves the structure into the Structure box. Click on the Structure box to start MarvinSketch. Then chose File > Save As > Files of Type > MDL Molfiles (*.mol) format.
In ChemIDplus Lite click the "Full Record" button. The structure will be at the top of the new page that appears along with the structure descriptors for InChI, InChIKey, and SMILES.
The ChemIDplus Advanced version automatically displays the structure at the top of the results page. Clicking on the "Enlarge Structure" link opens a window for viewing or manipulating 2D or 3D images of the structure.
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