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Nat Rev Mol Cell Biol. 2008 May;9(5):402-12. doi: 10.1038/nrm2395.

Transcriptional control of human p53-regulated genes.

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1
The Institute for Advanced Study, Princeton, New Jersey, USA. triley@ias.edu

Abstract

The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

PMID:
18431400
DOI:
10.1038/nrm2395
[Indexed for MEDLINE]
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