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Figure 2

Figure 2. Functional (GSIS) pancreas reserve in HME subjects (closed sq) versus controls (circles).. From: Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume.

A and B: The first-phase insulin and C-peptide response to a hyperglycaemic clamp was lower in HME subjects compared to controls. C: The glucose infusion rate (GIR), an estimation of the amount of glucose being metabolized, was not different between groups. D and E: Insulin secretion after an intravenous bolus of arginine was lower in carriers vs controls. * pā€Š=ā€Š0.028.

Sophie J. Bernelot Moens, et al. PLoS One. 2014;9(12):e115662.

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