A role for the phagosome in cytokine secretion

RZ Murray, JG Kay, DG Sangermani, JL Stow - Science, 2005 - science.sciencemag.org
Abstract Membrane traffic in activated macrophages is required for two critical events in
innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We
found a joint trafficking pathway linking both actions, which may economize membrane

Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα

AP Manderson, JG Kay, LA Hammond… - The Journal of cell …, 2007 - jcb.rupress.org
Abstract Activated macrophages secrete an array of proinflammatory cytokines, including
tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6), that are temporally secreted for
sequential roles in inflammation. We have previously characterized aspects of the

Composition of soil microbial communities enriched on a mixture of aromatic hydrocarbons

EA Greene, JG Kay, K Jaber… - Applied and …, 2000 - Am Soc Microbiol
ABSTRACT Soil contaminated with C5+, which contained benzene (45%, wt/wt),
dicyclopentadiene (DCPD) plus cyclopentadiene (together 20%), toluene (6%), styrene
(3%), xylenes (2%), naphthalene (2%), and smaller quantities of other compounds, served

Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis

…, J Venturato, FG Wylie, JG Kay… - American Journal of …, 2008 - Am Physiological Soc
The correct targeting and trafficking of the adherens junction protein epithelial cadherin (E-
cadherin) is a major determinant for the acquisition of epithelial cell polarity and for the
maintenance of epithelial integrity. The compartments and trafficking components required

Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup

JG Kay, RZ Murray, JK Pagan, JL Stow - Journal of Biological Chemistry, 2006 - ASBMB
Abstract Lipopolysaccharide-activated macrophages rapidly synthesize and secrete tumor
necrosis factor α (TNFα) to prime the immune system. Surface delivery of membrane
carrying newly synthesized TNFα is controlled and limited by the level of soluble N-

Matrix-isolated FeO, NiO, and CoO: Ground-state vibrational frequencies

DW Green, GT Reedy, JG Kay - Journal of Molecular Spectroscopy, 1979 - Elsevier
Abstract The infrared vibrational spectra of the FeO, NiO, and CoO molecules have been
observed in Ar matrices at 14 K. Frequencies for each of the isotopomers 54 Fe 16 O, 54 Fe
18 O, 56 Fe 16 O, 56 Fe 18 O, 58 Ni 16 O, 58 Ni 18 O, 60 Ni 16 O, 60 Ni 18 O, 59 Co 16 O,

Fusion, fission, and secretion during phagocytosis

KK Huynh, JG Kay, JL Stow, S Grinstein - Physiology, 2007 - Am Physiological Soc
Phagocytosis is essential for the elimination of pathogens and for clearance of apoptotic
bodies. The ingestion process entails extensive remodeling of the cellular membranes,
particularly when large and/or multiple particles are engulfed. The membrane fusion and

Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells

E Reefman, JG Kay, SM Wood… - The Journal of …, 2010 - Am Assoc Immnol
Abstract NK cells are renowned for their ability to kill virally infected or transformed host cells
by release of cytotoxic granules containing granzymes and perforin. NK cells also have
important regulatory capabilities chiefly mediated by secretion of cytokines, such as IFN-γ

Phosphatidylserine dynamics in cellular membranes

JG Kay, M Koivusalo, X Ma, T Wohland… - Molecular biology of …, 2012 - Am Soc Cell Biol
Abstract Much has been learned about the role of exofacial phosphatidylserine (PS) in
apoptosis and blood clotting using annexin V. However, because annexins are impermeant
and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use.

Dynamics and chemistry of marine stratocumulus (DYCOMS) experiment

…, CJ Weaver, BJ Huebert, JG Kay… - Bulletin of the …, 1988 - journals.ametsoc.org
Abstract A combined atmospheric chemistry-meteorology experiment, the Dynamics and
Chemistry of the Marine Stratocumulus (DYCOMS), was carried out during the summer of
1985 over the eastern Pacific Ocean using the NCAR Electra aircraft. The objectives were to