Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes

ME Dunbar, P Dann, CW Brown… - Journal of …, 2001 - Soc Endocrinology
Abstract We have previously demonstrated that overexpression of parathyroid hormone-
related protein (PTHrP) in the mammary glands of transgenic mice results in defects in
ductal elongation and branching during puberty and in lobuloalveolar development during
pregnancy. In addition, we have shown that PTHrP is necessary for the formation of the
initial ductal tree during embryonic mammary development. In order to examine the effect …