Cyclosporine inhibits catabolism of low‐density lipoproteins in HepG2 cells by about 25%

OA Rayyes, A Wallmark, C Florén - Hepatology, 1996 - Wiley Online Library
Abstract The aim of this study was to elucidate the possible causes of elevated low-density
lipoprotein (LDL)-cholesterol levels in transplanted patients treated with the
immunosuppressant drug, cyclosporine. HepG2 cells, from a well-differentiated cell-line of
hepatoma cells, were cultured and used as a model for in vitro hepatocytic LDL uptake.
Different concentrations of cyclosporine, which were within the range of concentrations ...