User profiles for author:Nicholas author:F. author:Parrish

Nicholas F Parrish

Section of Surgical Sciences, Vanderbilt University
Verified email at
Cited by 3223

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

…, S Wang, J Baalwa, MH Kraus, NF Parrish… - Journal of …, 2009 -
Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those
viruses actually responsible for productive clinical infection. We show in 12 acutely infected

[HTML][HTML] An integrated map of structural variation in 2,504 human genomes

…, DM Muzny, BJ Nelson, A Noor, NF Parrish… - Nature, 2015 -
Summary Structural variants (SVs) are implicated in numerous diseases and make up the
majority of varying nucleotides among human genomes. Here we describe an integrated set
of eight SV classes comprising both balanced and unbalanced variants, which we

Phenotypic properties of transmitted founder HIV-1

NF Parrish, F Gao, H Li, EE Giorgi… - Proceedings of the …, 2013 - National Acad Sciences
Abstract Defining the virus–host interactions responsible for HIV-1 transmission, including
the phenotypic requirements of viruses capable of establishing de novo infections, could be
important for AIDS vaccine development. Previous analyses have failed to identify

[HTML][HTML] Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7

NF Parrish, CB Wilen, LB Banks, SS Iyer… - PLoS …, 2012 -
Abstract Sexual transmission of human immunodeficiency virus type 1 (HIV-1) most often
results from productive infection by a single transmitted/founder (T/F) virus, indicating a
stringent mucosal bottleneck. Understanding the viral traits that overcome this bottleneck

Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins

CB Wilen, NF Parrish, JM Pfaff, JM Decker… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across
mucosal barriers is responsible for the vast majority of new infections. This relatively
inefficient process results in the transmission of a single transmitted/founder (T/F) virus, from

Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5

ZF Parker, SS Iyer, CB Wilen, NF Parrish… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT Infection by HIV-1 most often results from the successful transmission and
propagation of a single virus variant, termed the transmitted/founder (T/F) virus. Here, we
compared the attachment and entry properties of envelope (Env) glycoproteins from T/F and

Primary infection by a human immunodeficiency virus with atypical coreceptor tropism

C Jiang, NF Parrish, CB Wilen, H Li, Y Chen… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT The great majority of human immunodeficiency virus type 1 (HIV-1) strains enter
CD4+ target cells by interacting with one of two coreceptors, CCR5 or CXCR4. Here we
describe a transmitted/founder (T/F) virus (ZP6248) that was profoundly impaired in its ability

[HTML][HTML] Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry

JA Wojcechowskyj, CA Didigu, JY Lee, NF Parrish… - Cell host & …, 2013 - Elsevier
Receptor engagement by HIV-1 during host cell entry activates signaling pathways that can
reprogram the cell for optimal viral replication. To obtain a global view of the signaling
events induced during HIV-1 entry, we conducted a quantitative phosphoproteomics screen

[HTML][HTML] Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones

J Baalwa, S Wang, NF Parrish, JM Decker, BF Keele… - Virology, 2013 - Elsevier
We report the molecular identification, cloning and initial biological characterization of 12 full-
length HIV-1 subtype A, D and A/D recombinant transmitted/founder (T/F) genomes. T/F
genomes contained intact canonical open reading frames and all T/F viruses were

Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green …

CW Gnanadurai, I Pandrea, NF Parrish… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT Understanding the lack of disease progression in nonpathogenic simian
immunodeficiency virus (SIV) infections is essential for deciphering the
immunopathogenesis of human AIDS. Yet, in vivo studies have been hampered by a paucity