Abstract Bile acid synthesis, determined by conversion of [4-14C] cholesterol into bile acids
in rat and human hepatocytes and by measurement of mass production of bile acids in rat
hepatocytes, was dose-dependently decreased by cyclosporin A, with 52%(rat) and
45%(human) inhibition of 10 microM. The decreased bile acid production in rat hepatocytes
was due only to a fall in the synthesis of beta-muricholic and chenodeoxycholic acids (-64 ...