Cyclosporine A and rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma

R Tory, K Sachs-Barrable, JS Hill, KM Wasan - International journal of …, 2008 - Elsevier
PURPOSE: Cyclosporine A (CsA), Rapamycin (RAPA), Tacrolimus (FK-506) and
Mycophenolate mofetil (MMF) are immunosuppressants that are widely used in solid organ
transplant patients. However, some of these drugs have been reported to cause
dyslipidemia in patients. Our aim was to determine the effects of these drugs on in vitro
cholesteryl ester transfer protein (CETP), hepatic lipase (HL) and lipoprotein lipase (LPL) ...