User profiles for author:Eric author:E. author:Schadt

Eric Schadt

Professor of Genetics and Genomic Sciences, Mount Sinai School of Medicine
Verified email at mssm.edu
Cited by 47318

[HTML][HTML] Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, G Radford-Smith, CG Mathew, JD Rioux, EE Schadt… - nature, 2012 - ncbi.nlm.nih.gov
Abstract Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of
inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry with
rising prevalence in other populations 1. Genome-wide association studies (GWAS) and

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, HM Stringham, MN Weedon, E Wheeler… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations
between body mass index and~ 2.8 million SNPs in up to 123,865 individuals with targeted

[CITATION][C] Genetics of gene expression surveyed in maize, mouse and man

EE Schadt, SA Monks, TA Drake, AJ Lusis - Nature, 2003 - Nature Publishing Group

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

…, PM Loerch, CD Armour, R Santos, EE Schadt… - …, 2003 - science.sciencemag.org
Abstract Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in
development, physiology, and disease, and more than half of human genes are alternatively
spliced. To understand the biological roles and regulation of alternative splicing across

Common variants at 30 loci contribute to polygenic dyslipidemia

…, GM Peloso, S Demissie, K Musunuru, EE Schadt… - Nature …, 2009 - nature.com
Abstract Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the
polygenic basis of these traits, we conducted genome-wide association screens in 19,840

[CITATION][C] Genetics of gene expression and its effect on disease

…, JR Gulcher, ML Reitman, A Kong, EE Schadt… - …, 2008 - Nature Publishing Group

[HTML][HTML] An integrative genomics approach to infer causal associations between gene expression and disease

EE Schadt, J Lamb, X Yang, J Zhu, S Edwards… - Nature …, 2005 - ncbi.nlm.nih.gov
Abstract A key goal of biomedical research is to elucidate the complex network of gene
interactions underlying complex traits such as common human diseases. Here we detail a
multistep procedure for identifying potential key drivers of complex traits that integrates DNA-

[HTML][HTML] Mapping the genetic architecture of gene expression in human liver

EE Schadt, C Molony, E Chudin, K Hao, X Yang… - PLoS …, 2008 - journals.plos.org
Abstract Genetic variants that are associated with common human diseases do not lead
directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce
changes in higher-order disease traits. Therefore, identifying the molecular phenotypes that

[HTML][HTML] Variations in DNA elucidate molecular networks that cause disease

…, S Horvath, TA Drake, AJ Lusis, EE Schadt - Nature, 2008 - ncbi.nlm.nih.gov
Abstract Identifying variations in DNA that increase susceptibility to disease is one of the
primary aims of genetic studies using a forward genetics approach. However, identification
of disease-susceptibility genes by means of such studies provides limited functional

[HTML][HTML] Origins of the E. coli strain causing an outbreak of hemolytic–uremic syndrome in Germany

…, KA Krogfelt, JP Nataro, EE Schadt… - … England Journal of …, 2011 - Mass Medical Soc
Background A large outbreak of diarrhea and the hemolytic–uremic syndrome caused by an
unusual serotype of Shiga-toxin–producing Escherichia coli (O104: H4) began in Germany
in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin–