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A novel cell line that retains the morphological characteristics of the cells and matrix of odontogenic myxoma. - PubMed - NCBI
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J Oral Pathol Med. 2000 Mar;29(3):129-38.

A novel cell line that retains the morphological characteristics of the cells and matrix of odontogenic myxoma.

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1
Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.

Abstract

Little is known about the histogenesis of the human odontogenic myxoma or the relation between tumour cells and the matrix. In order to attempt to remedy this situation, we established and investigated a cell line derived from a human odontogenic myxoma. To our knowledge this is the first cell line derived from this tumour. The cell line, named Mix 1, preserved features of the tumour cells. Mix 1 cells expressed vimentin, type I collagen, fibronectin, tenascin and hyaluronic acid. Ultrastructural analysis of cells of the tumour and cell line demonstrated similarities, both containing Golgi apparatus, rough endoplasmic reticulum and mitochondria indicative of secretory cells. Ultrastructural analysis showed the matrix to be represented by bundles of collagen fibrils in the tumour, and by irregular filaments in cultures more than 60 days old. The Mix 1 cell line promises to be an excellent model for investigating the biology of the odontogenic myxoma.

PMID:
10738940
[Indexed for MEDLINE]
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