Cytokines are critical mediators of inflammation and host defenses. Regulation of cytokines can occur at various stages of gene expression, including transcription, mRNA export, and post- transcriptional and translational levels. Among these modes of regulation, post-transcriptional regulation has been shown to play a vital role in controlling the expression of cytokines by modulating mRNA stability. The stability of cytokine mRNAs, including TNFα, IL-6, and IL-8, has been reported to be altered by the presence of AU-rich elements (AREs) located in the 3′-untranslated regions (3′UTRs) of the mRNAs. Numerous RNA-binding proteins and microRNAs bind to these 3′UTRs to regulate the stability and/or translation of the mRNAs. Thus, this paper describes the cooperative function between RNA-binding proteins and miRNAs and how they regulate AU-rich elements containing cytokine mRNA stability/degradation and translation. These mRNA control mechanisms can potentially influence inflammation as it relates to oral biology, including periodontal diseases and oral pharyngeal cancer progression.

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Vol 91, Issue 7, 2012

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Control of Cytokine mRNA Expression by RNA-binding Proteins and microRNAs

V. Palanisamy1, #, A. Jakymiw1, #, E.A. Van Tubergen3, #, N.J. D’Silva3, 4, K.L. Kirkwood12*Department of Craniofacial Biology, Medical University of South Carolina, Charleston, SC, USADepartment of Microbiology and Immunology, Center for Oral Health Research, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USADepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USADepartment of Pathology, University of Michigan, Ann Arbor, MI, USA


Journal of Dental Research

Vol 91, Issue 7, pp. 651 - 658

First published date: February-01-2012


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V. Palanisamy, A. Jakymiw, E.A. Van Tubergen, N.J. D’Silva, and K.L. Kirkwood
Journal of Dental Research 2012 91:7, 651-658

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