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PubMed Central, Fig. 7.: Biol Open. 2013 Dec 15; 2(12): 1336–1345. Published online 2013 Oct 23. doi:  10.1242/bio.20135397
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Fig. 7.

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Model of Ets1 regulation of Notch signaling.

When Ets1 is over-expressed it leads to upregulation of ΔNp63, which then inhibits Notch signaling and thereby prevents the transition of keratinocytes from basal to spinous cell fates. The dashed line indicates the possibility that Ets1 might also directly regulate expression of Notch genes in addition to its indirect control of Notch signaling via upregulation of ΔNp63.

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