University at Buffalo - The State University of New York
Skip to Content
The Genotype-Tissue Expression (GTEx) project. - PubMed - NCBI
Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Genet. 2013 Jun;45(6):580-5. doi: 10.1038/ng.2653.

The Genotype-Tissue Expression (GTEx) project.

Author information

1
National Disease Research Interchange, Philadelphia, Pennsylvania, USA.

Abstract

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

PMID:
23715323
PMCID:
PMC4010069
DOI:
10.1038/ng.2653
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center