EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer

…, CI Tsien, JMG Taylor, NJ D'Silva… - Journal of clinical …, 2008 -
Purpose To prospectively identify markers of response to therapy and outcome in an organ-
sparing trial for advanced oropharyngeal cancer. Patients and Methods Pretreatment
biopsies were examined for expression of epidermal growth factor receptor (EGFR), p16, Bcl-

Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number

…, ME Prince, CI Tsien, NJ D'Silva… - Journal of clinical …, 2008 -
Purpose To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy
(CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the
effect of human papilloma virus (HPV) on response and outcome. Patients and Methods

Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma

…, RC Inglehart, NJ D'Silva - Journal of dental …, 2013 -
An understanding of the process by which tumor cells destroy the basement membrane of
the surface epithelium, invade, and metastasize is essential to the development of novel
treatment of head and neck squamous cell carcinoma (HNSCC). In recent years, there has

Metastatic tumors in the jaws: a retrospective study of 114 cases

NJ D'Silva, DJ Summerlin, KG Cordell… - The Journal of the …, 2006 - Elsevier
Background Malignancies involving the bones are metastatic tumors more commonly than
primary tumors. In this retrospective study, the authors review metastatic disease in the jaws.
Methods The authors retrieved cases of metastatic disease in the jaws over a 45-year period

[HTML][HTML] Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer

…, P Kamarajan, N Joo, JY Huang, E Verdin, NJ D'silva… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Several sirtuin family members (SIRT1-7), which are evolutionarily
conserved NAD-dependent deacetylases, play an important role in carcinogenesis.
However, their role in oral cancer has not yet been investigated. Therefore, the objective of

Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor …

…, A Eisbruch, CI Tsien, JMG Taylor, NJ D'Silva… - International Journal of …, 2007 - Elsevier
Induction chemotherapy and concurrent chemoradiation for responders or immediate
surgery for non-responders is an effective treatment strategy head and neck squamous cell
carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

…, AM Chinnaiyan, S Varambally, NJ D'Silva - Oncogene, 2011 -
Abstract Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple
aggressive cancers, such as head and neck squamous cell carcinoma, melanoma and
pancreatic cancer. However, the mechanistic basis of rap1GAP downregulation in cancers is

[HTML][HTML] (−)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

…, B Kumar, J Chen, TE Carey, CR Bradford, NJ D'Silva - Neoplasia, 2006 - Elsevier
Abstract Resistance to chemotherapy is a common problem encountered in the treatment of
head and neck squamous cell carcinoma (HNSCC). Chemoresistant HNSCC tumors
frequently overexpress antiapoptotic proteins, such as BCI-x L.(−)-Gossypol, the negative

Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts

…, ET Keller, G Xiao, RT Franceschi, NJ D'Silva… - Journal of Biological …, 2004 - ASBMB
Abstract Parathyroid hormone-related protein (PTHrP) regulates proliferation and
differentiation of osteoblastic cells via binding to the parathyroid hormone receptor (PTH-
1R). The cAMP-dependent protein kinase A pathway governs the majority of these effects,

Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer

…, K Van Golen, J Greenson, G Li, NJ D'Silva… - Cancer Research, 2006 - AACR
Human chromosome 1p35-p36 has long been suspected to harbor a tumor suppressor
gene in pancreatic cancer and other tumors. We found that expression of rap1GAP, a gene
located in this chromosomal region, is significantly down-regulated in pancreatic cancer.