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Mira Edgerton Phd, DDS

Department of Oral Biology

Research Professor

Specialty/Research Focus

Oral Biology; Prosthodontics

Faculty Research Profile

 

 

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Journal Articles:

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Abstracts: 

  • Kumar R., Conti F., Saraswat D., Bajawa J.S., Li R.A., Edgerton M. Polyamine transporters Dur3 and Dur31 facilitate uptake of antifungal cationic peptide. 11th ASM Conference on Candida and Candidiasis. 2012. 
  • Tati S, Jang W.S., Edgerton M. Histatin 5 differential binding to surface glucans and mannans among C. albicans and C. glabrata strains does not influence its toxicity. 11th ASM Conference on Candida and Candidiasis. 2012. 
  • Li R., Kumar R., Edgerton M. The role of Candida albicans TPO transporters in efflux of Histatin 5. 11th ASM Conference on Candida and Candidiasis. 2012. 
  • Edgerton M. Cleavage of signaling mucin Msb2 is necessary for the activation of Cek1 MAPK pathway and virulence in Candida albicans. 11th Annual Mark Wilson Conference. 2012. 
  • Puri S., Kumar R., Chadha S., Tati S., Conti H.R., Cullen P.J., Edgerton M. Cleavage of signaling mucin Msb2 is necessary for the activation of Cek1 MAPK pathway and virulence in Candida albicans. 11th ASM Conference on Candida and Candidiasis. 2012.

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  • Gaffen S, Conti F., Freeman H.R., Holland A., Peterson S., Hernandez-Santos A.C., Jang N., Baker OJ, Pandiyan O., Lenardo P., Edgerton M. Th17, Treg and STAT3 signaling in oral mucosal candidiasis: A new paradigm in antifungal immunity. Gordon Conference on Fungal Immunity. 2011. 
  • Edgerton M, Jang W.S., Baker OJ, Conti H.R., Freeman A., Holland S., Gaffen S. The salivary antifungal protein Histatin 5 is an innate immune molecule regulated by IL 17. Gordon Conference on Funal Immunity. 2011. 
  • Edgerton M, Kumar R., Chadha S., Bajawa J.S., Jang W.S.. Uptake of the antifungal protein Histatin 5 by C albicans is via the native polyamine transproter Dur2p. 10th Annual Mark Wilson Conference. 2011. 
  • Bajwa J.S., Kumar R., Chadha S., Jang W.S., Edgerton M. Polyamine transporter Dur3 mediates salivary Histatin 5 uptake. IADR Conference. 2011. 
  • Chadha S., Bajwa J.S., Sun J.N., Paluszynski J, Jang W.S., Edgerton M. Spermidine plasma membrane transporter Dur3 is involved in the translocation of Histatin 5 in C. albicans. 10th Candida and Candidiasis Congerence. 2010. 
  • Jang W.S., Sun J.N., Edgerton M. Salivary Histatin 5 Internalization by Translocation, but not Endocytosis, kills Candida albicans by Disruption of Intracellular Ionic Balance ASM. 10th Candida and Candidiasis Conference. 2010. 
  • Chadha S., Paluszynski J.N., Bajwa J.S., Jang W.S., Edgerton M. C. albicans Msb2 is secreted mucin-like proteins that contributes to adhesion and virulence in oropharyngeal candidiasis. 10th Candida and Candidiasis Conference. 2010. 
  • Gaffen S, Conti F., Shen F., Sun J.S., Lindemann M.J., Hai J.H., Masso-Welch P., Edgerton M. Th17/IL-17 receptor signaling and not Th1 cells are essential for host defense against oral candidiasis. 10th Candida and Candidiasis Conference. 2010. 
  • Gaffen SL, Conti HR, Shen F, Nayyar N, Stocum E, Sun J, Lindeman M, Ho A, Hai JH, Masso-Welch P, Edgerton M. Th17/IL-17 receptor signaling and not Th1 cells are essential for mucosal host defense against oral candidiasis. Cytokine. 2009; 48(1). 
  • Li XS, Sun JN, Edgerton M. Lysine Residues are Required for Histatin Translocation into Candida albicans. J Dent Res. 2007; 86(A). 
  • Sun JN, Li XS, Edgerton M. ATP hydrolysis mediates C. albicans ssa2p-Histatin5 complex formation. J Dent Res. 2007; 86(A). 
  • Nayaar N, Filler N, Solis N, Sun JN, Edgerton M. Ssa1 proteins are important virulence determinants in Candida albicans. J Dent Res. 2007; 86(A). 
  • Okamoto-Shibayama K, Vylkova S, Edgerton M. Microarray analyses of Candida albicans transporter gene expression with Hst 5. J Dent Res. 2007; 86(A). 
  • Vylkova S, Sun JN, Edgerton M. Human beta defensins and histatin 5 have overlapping mechanisms of killing of Candida albicans. ASM 160th General Meeting. 2006; F(004). 
  • Sun JN, Li XS, Edgerton M. Candida albicans cell wall HSP70 proteins mediate binding with the cationic peptide Histatin 5. 8th ASM Conference on Candida and Candidiasis. 2006; A(166). 
  • Vylkova S, Nayyar N, Edgerton M. Human beta defensins kill Candida albicans in a salt-sensitive and energy-dependent manner that does not involve membrane disruption. 8th ASM Conference on Candida and Candidiasis. 2006; C(138). 
  • Pusateri C, Vylkova S, Monaco E, Edgerton M. Sensitivity of Candida albicans Biofilm Cells to Histatin 5. J Dent Res. 2006. 
  • Sun JN, Vylkova S, Baev D, Edgerton M. Transcriptional and Translational Levels of Candida alvicans TRK1. J Dent Res. 2005; 84(A). 
  • Li XS, Baev D, Edgerton M. Candida albicans HSP70 Deletion Reduces Antifungal Activity of Histatin 5. J Dent Res. 2005; 84(A). 
  • Vylkova S, Baev D, Edgerton M. Salivary Histatin 5 Targets TRK1 Potassium Transporter in Candida albicans. J Dent Res. 2005; 84(A). 
  • Berner JC, Vylkova S, Baev D, Edgerton M. Histatin 5-Induced Propidium Iodide Uptake in Candida albicans is Through TRK1p. J Dent Res. 2005; 84(A). 
  • Li XS, Reddy MS, Edgerton M. Candida Albicans heat shock proteins (Ssa) are identified as Histatin binding proteins and mediate fungicidal activity of Histatin 5. J Dent Res. 2003; 82(A). 
  • Vylkova S, Baev D, Li XS, Edgerton M. Histatin 5 killing of Candida albicans involves TOK1 potassium channels. J Dent Res. 2003; 82(A). 
  • Wunder DE, Edgerton M. Susceptibility of yeast SOD mutants to Histatin 5 treatment. J Dent Res. 2003; 82(A). 
  • Li XS, Baev D, Keng PC, Edgerton M. Histatin 5 causes cell size reduction and G0/G1 cell cycle arrest in Candida albicans. J Dent Res. 2002; 81(A235). 
  • Wunder DE, Dong J, Baev D, Edgerton M. Generation of reactive oxygen species and chromosomal changes following Hst 5 treatment of Candida albicans. J Dent Res. 2002; 81(A236). 
  • Edgerton M, Li X, Baev D, Dong J, Keng P. Histatins cause disordered volume regulation and G0/G1 cell cycle arrest in Candida albicans.. ASM Conference on Candida and Candidiasis. 2002. 
  • Edgerton M, Baev D, Li X, Dong J, Keng P. Histatins cause disordered volume regulation and G1 cell cycle arrest in C. albicans. Microbial Pathogenesis and Host Response. 2001. 
  • Patel R, Koshlukova S, Araujo MBW, Edgerton M. ATP release is inhibited by increase in (Ca2+) and (MG2+).. J. Dent. Res.. 2000; 79(174). 
  • Araujo, MBW, Koshlukova, S, Patel, R, Mira Edgerton. Salivary histatin 5 and Human neutrophil peptide- 1 (NP-1) share a comon candidacidal pathway (HNP-1). J Dent Res. 2000; 79(248). 
  • Patel R, Koshlukva S., Lloyd T., Araujo MBW, Edgerton M. Candidacidal actvity of salivary histatins in physiological inorganic buffers.. J Dent Res. 1999; 78(1894). 
  • Koshlukova S, Lo T, Chrzan B, Edgerton M. Histatin Interaction with Candida albicans Envelope Protein is Related to Candidacidal Activity. J Dent Res. 1997; 76(2723). 
  • Edgerton M, Lo T, Anthony Raj PA. Salivary Histatin 3 and Histatin 5 exhibit secific binding to yeast cell membranes.. J Dent Res. 1996; 75(2723). 
  • Gauri, Edgerton M, Anthony Raj P. Bactenecin 5: A potent bactericidal agent for Porhyromonas gingivalis.. J Dent Res. 1996; 75(3289). 
  • Lee W, Loza J, Edgerton M, Bryant HU, Turner AS. Effect of Ovariectomy on Mandibular Bone in Ewes.. J Dent Res. 1996; 75(1579). 
  • Subramanian P, Edgerton M, Raj PA. Synthesis and candidacidal activity of the fragments of salivary histatin 3 and histatin 5.. J Dent Res. 1995; 74. 
  • Edgerton M, Lo S, Scannapieco FA, Levine MJ. Titanium salivary pellicle inhibits adhesion of streptococcal species.. J Dent Res. 1994; 73(2168). 
  • Edgerton M, Lo SE, Levine MJ. Histatins induce leakage from C. albicans cells and model liposome membranes.. J Dent Res. 1993; 72. 
  • Edgerton M, Levine M, Raj PA. Salivary histatin 5 coated to PMMA retains anticandidal properties.. J Am Soc Microbiol. 1993. 
  • Raj PA, Genco RJ, Levine MJ, Edgerton M. Dependence of secondary structure for candidacidal activity of bactenecins and defensins.. J Dent Res. 1993; 72. 
  • Edgerton M, Scannapieco FA, Reddy MS, Levine MJ. Candida albicans selectively absorbs salivary mucins.. J Dent Res. 1992; 71. 
  • Edgerton M, Bradway SD, Levine MJ. In vitro adhesion of salivary molecules and Candida albicans to PMMA beads.. J Dent Res. 1990; 69(1689). 
  • Edgerton M, Yoon KJ, Levine MJ. Comparison of acquired salivary pellicles from denture surfaces.. J Dent Res. 1989; 68(1388). 
  • Yoon KJ, Edgerton M, Levine MJ. Binding of Candida albicans to human saliva and acquired pellicles.. J Dent Res. 1989; 68(1389). 
  • Edgerton M, Cohen RE, Aguirre A, Reddy M, Levine MJ. Immunochemical Analysis of Human Palatine Salivary Mucins. J Dent Res. 1988; 67. 
  • Edgerton M, Cohen RE, Levine MJ. Characterization of human palatine saliva.. J Dent Res. 1987; 66(1225). 
  • Edgerton M, Bengtsson CE, Slots J. Clinical and microbiological studies of patients on cancer chemotherapy.. J Dent Res. 1983; 62(1133).

Books and Book Chapters:

  • Puri S, Edgerton M. Candida albicans Ssa: An Hsp70 homologue and virulence factor. Moonlighting Cell Stres Proteins in Microbial Infections. 2013; 14.
  • Jang WS, Edgerton M. Salivary Histatins: Structure, Function and Mechanisms of Antifungal Activity. Candida and Candidiasis. 2011; 13.

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