< < and having better lung function. African Americans have and having better lung function. African Americans havand having better lung function. African Americans have a 5- to 10and having better lung function. African Americans have a 5- and having better lung functiontent="Mary C. Rose" /> ntent="Mary C. Rose" /> sthma. Methods Genomic DNA, collected from a cohort of Africsthma. Methods Genomic DNA, collected from a cohort of Afristhma. Methods Genomic DNA, collected from a cohort of Afristhma. Methods Genomic DNA, collected from a cohort of African American asthmatic subjects, was used to detect the MUC7 VNTR polymorphisms and to analyze tsthma. Methods Genomic DNA, collected from a cohort of African American asthmatic subjects, was used to detect the MUC7 VNTR polymorphisms and to analyze the rs9982010 single nucleotide polymorphism. Results A logistic regression analysis showed that the MUC7*it a high degree of polymorphisms that generate a variable number of tandem repeat (VNTR) domains. <i>MUC7</i> typically encodes for 6 VNTRs, each with 23 amino acids. In a northern European cohort, a polymorphism encoding <i>MUC7*5</i> (5-VNTR) is in 100% linkage disequilibrium with the single nucleotide polymorphism rs9982010 and associated with a decreased risk of being asthmatic and having better lung function. African Americans have a 5- to 10-fold increase in incidence of asthma relative to whites, who are believed to be partially associated with higher genetic susceptibility. Occurrence of the rs9982010 and <i>MUC7</i> allelic frequencies was evaluated in inner-city African Americans to test their association with a diagnosis of asthma.</p><h3>Methods</h3> <p>Genomic DNA, collected from a cohort of African American asthmatic subjects, was used to detect the <i>MUC7</i> VNTR polymorphisms and to analyze the rs9982010 single nucleotide polymorphism.</p><h3>Results</h3> <p>A logistic regression analysis showed that the <i>MUC7*5</i>-VNTR allele decreased the likelihood of a diagnosis of asthma (odds ratio, 0.173 [95% confidence interval, 0.041-0.737]; <i>P</i> &lt; 0.018) and is not in a strong linkage disequilibrium with the rs9982010 (<i>r</i><sup>2</sup> = 0.03; odds ratio, 66; confidence interval, 5.913-736.72). A novel <i>MUC7*4</i>-VNTR polymorphism, identified in an African American nonasthmatic individual, was linked to a structural rearrangement of the VNTR domain.</p><h3>Conclusions</h3> <p>These data extend the association of <i>MUC7*5</i> allelic polymorphisms and asthma to inner-city African Americans.</p>" /> it a high degree of polymorphisms that generate a variable number of tandem repeat it a high degree of polymorphisms that generate a variable number of tandeit a high degree of polymorphisms ate" content="2009/12/01" /> ate" content="2009/12/01" /> ate" content="2009/12/01" /> eorge Washington University, Washington, DC." /> Supplement;citation_journal_abbrev=Pediatr Pulmonol Suppl;citation_author=FD. Martinez;citation_title=Definition of pediatric asthma and associated risk factors.;citation_pages=9-12;citation_volume=15;citation_year=1997;citation_pmid=9316095" /> 0;citation_issue=3;citation_pmid=10981263;citation_doi=10.1385/CRIAI:18:3:311" /> 06;citation_issue=1;citation_pmid=16371599;citation_doi=10.1152/physrev.00010.2005" /> ousseau;citation_author=LE. Vinall;citation_author=SL. Butterworth;citation_title=MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function.;citation_pages=417-427;citation_volume=70;citation_year=2006;citation_issue=Pt 4;citation_pmid=16759176;citation_doi=10.1111/j.1469-1809.2006.00250.x" /> man submandibular-sublingual saliva.;citation_pages=111-122;citation_volume=108;citation_year=1982;citation_issue=1;citation_pmid=7139659;citation_doi=10.1016/S0008-6215(00)81896-0" /> 0.1186/1743-422X-3-99" /> 00.1186/1743-422X-3-99" /> 000.1186/1743-422X-3-99" /> 000.1180.1186/1743-422X-3-99" /> 00RRRR4f5hIMsXPqeKmXs1U.css" media="all" /> R4f5hIMsXPqeKmXs1U.css" media="all" /> Yr5bNspjJYbpy6C490iEMIR0YYr5bNspjJYbpy6C490iEMttttttsssss ssJ n-devn-device-width: 768px), (max-device-width: 800px) and (min-width: 768px) and (orientation:landscape)","norn-device-wn-device-width: 768px), (max-device-width: 800px) and (min-width: 768px) and (orientation:landscape)","normal":"all and (min-width: 980px) and (min-device-width: 980px), all and (max-device-width: 1024px) and (min-win-device-width: 768px), (maxn-device-w