<<<< eeetch" href="//stats.g.doubleclick.net" /> etch" href="//stats.g.doubleclick.net" /> etch" href="//stats.g.doubleclick.net" /> enomes of more than 600 Europeans and East Asians, Vernotenomes of more than 600 Europeans and East Asians, Vernoenomes of more than 600 Europeans and East Asians, Vernot and Akey (p. [1017][1], published online 29 January) identified Neenomes of more than 600 Europeans and East Asians, Vernot and Akey (p. [1017][1], published online 29 Jenomes of more than 600 Europeans and East Asians, Vernot and Akey (p. enomes of more than 600 Europeans and East Asians, Vernot and Akey (p. [1017][1], published onlienomes of more than 600 Europeans and East Asians, Vernot and Akey (p. [1017][1], published online 29 January) identified Neandertal sequences within modern humans that taken together span approximately 20% of the Neandertal genome. Some Neandertal-derived sequences appear to be under positive selection in humans, including several genes associated with skin phenotypes. [1]: /lookup/doi/10.1126/science.1245938" /> tract" lang="en" content="<p>Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1 to 3% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering more than 15 gigabases of introgressed sequence that spans ~20% of the Neandertal genome (false discovery rate = 5%). Analyses of surviving archaic lineages suggest that there were fitness costs to hybridization, admixture occurred both before and after divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes. Our results provide a new avenue for paleogenomics studies, allowing substantial amounts of population-level DNA sequetract" lang="en" content="<p>Anatomically modern hutract" lang="en" content="<p>Anatomically modern humans overlapped and mated with Neandertatract" lang="en" content="<p>Anatomically modern humans otract" lan="citation_mjid" content="sci;343/6174/1017" /> ="citation_mjid" content="sci;343/6174/1017" /> <="citation_mjid" content="sci;343/6174/1017" /="citation_mjid" content="sci;343/6174/1017" /="citation_mjid" content="sci;343/6174/1017" /> <="citation_mjid" content="sci;343/6174/1017" /> itle=Next-generation hybridization and introgression.;citation_pages=179-189;citation_volume=108;citation_year=2012;citation_issue=3;citation_pmid=21897439;citation_doi=10.1038/hdy.2011.68" /> in;citation_author=M. Slatkin;citation_author=R. Nielsen;citation_author=J. Kelso;citation_author=M. Lachmann;citation_author=D. Reich;citation_author=S. 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Jobin;citation_author=S. Kulkarni;citation_author=A. McWhinnie;citation_author=K. Dalva;citation_author=L. Gragert;citation_author=F. Babrzadeh;citatitle=Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation;citation_volume=278;citation_year=2003;citation_pmid=12624109;citation_doi=10.1074/jbc.M300508200" /> itle=Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation;citation_volume=278;citation_year=2003;citation_pmid=12624109;citation_doi=10.1074/jbc.M300508200" /> n_author=J. C. Watkins;citation_author=J. D. Wall;citation_title=Genetic evidence for archaic admixture in Africa;citation_volume=108;citation_year=2011;citation_pmid=21896735;citation_doi=10.1073/pnas.1109300108" /> tation_issn=1088-9051;citation_pmid=16251467;citation_doi=10.1101/gr.3709305" /> ation_author=S. Balasubramanian;citation_author=A. Chakravarti;citation_author=B. M. Knoppers;citation_author=G. 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