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Keith                          Kirkwood

Keith L. Kirkwood 

Department of Oral Biology

Professor

Specialty/Research Focus

Endodontics; Periodontics

 
Professional Summary:

My research program has been focused on innate immune signaling and cytokine biology as it relates to inflammation, bone loss, and oral cancer progression. My translational research explores the roles of posttranscriptional cytokine regulation in oral inflammation with the ultimate possibilities of developing novel therapies to control chronic oral inflammation.

Education and Training:
  • Fellowship, Department of Pharmacology and Toxicology, University of Buffalo (1999)
  • PhD, University of Buffalo, Dentist Scientist Award (1997)
  • Cert, University of Buffalo (1997)
  • DDS, West Virginia University (1991)
  • BA, West Virginia University, Freshman Chemistry Award, Mary Baab Randolph Student Research Fellowship, (1987)
Employment:
  • Professor, Oral Biology, University at Buffalo (2017-present)
  • Professor, Oral Health Sciences, Medical University of South Carolina, College of Dental Medicine (2008–2017)
  • Associate Professor, Periodontics and Oral Medicine, University of Michigan, School of Dentistry (2003–2008)
  • Research Assistant Professor, Pharmacology and Toxicology, University of Buffalo (2002–2003)
  • Assistant Professor, Periodontics And Endodontics, University of Buffalo (2000–2003)
  • Clinical Assistant Professor, Oral Biology, University of Buffalo (1997–2003)
  • Clinical Assistant Professor, Periodontics And Endodontics, University of Buffalo (1997–2000)
  • Post Doctoral Fellow, Pharmacology and Toxicology, University of Buffalo (1997–1999)
  • Clinical Instructor, Periodontics And Endodontics, University of Buffalo (1995–1997)
Awards and Honors:
  • Sunstar - AAP Foundation Research Fellowship (2016)
  • Fellow of the AADR (2016)
  • IADR/GSK Innovation in Oral Care Award (2014)
  • IADR Distinguished Scientist Award for Pharmacology/Therapeutics/Toxicology Research (2013)
  • IADR/GSK Innovation in Oral Care Award (2008)
  • Tarrson Fellowship Career Development Award (2005)
  • Young Investigator Award (2002)
  • Osseointegration Foundation Research Grant Award (2000)
  • Student Clinician Award (1990)
  • Quintessence Research Award (1990)
  • Dentist- Scientist Award
  • Mark Diamond Research Award
  • Individual National Research Service Award
  • American Dental Association Student Clinician Program
  • Mary Baab Randolph Student Research Fellowship
  • Freshman Chemistry Award

Research Expertise:
  • Oral Biology: Cytokine gene regulation in bone with identification of novel therapeutics targets and applied nolecular pharmacology targeting signaling mechanisms for therapeutic purposes in inflammatory bone diseases.

Journal Articles:
See all (58 more)
Books and Book Chapters:
  • Kirkwood KL, Nisengard RJ, Haake SK, Miyasaki KT. Immunity and Inflammation: Basic Concepts. Carranza's Clinical Periodontology, 10th Edition. 2007.
Abstracts:
  • Kirkwood K, Ciancio SG, Mather M. Clinical evaluation of a smoking deterrent breathspray compared to a placebo spray. J Dent Res. 2002; 81(2328).
  • Kirkwood K, Ciancio SG, Mather M. Clinical evaluation of a smoking deterrent mouthwash. J Dent Res. 2001; 80(1504).
  • Kirkwood KL, Dziak R, Bradford P. Inositol trisphosphate receptor subtype analysis in human osteosarcona cells.. J Dent Res. 1995; 74(318).
  • Kirkwood KL, Wilson ME. IgG antibodies to A. actinomycetemcomitans 16.6 kDa OMP in juvenile periodontitis.. J Dent Res. ; 73(451).

Professional Memberships:
  • American Association of Dental Research; Secretary/Treasurer (2002–2005)
  • American Academy of Periodontology; Subcommittee on Research Submission (2001–present)
  • American Dental Association
  • New York State Dental Association
  • Eight District Dental & Erie County Dental Societies
  • New York State Society of Periodontists
  • Academy of Osseointegration
  • American Association for Bone and Mineral Research
Presentations:
  • "Differential Regulation of MMP-13 by Chemical Modified Tetracyclines in Osteoblasts" 8oth Annual Session of the IADR/31th (2002)
  • "Dental Implications of the 40 Most Commonly Prescribed Medications" Continuing Dental Medicine, University of Buffalo Dental Medicine (2001)
  • "Systemic Medications and Dental Implications" , University of Rochester (2001)
  • "Impact of Herbal Therapies on Dental Practice" Continuing Dental Education, University of Buffalo Dental Medicine (2001)
  • "Expression Profiling of Genes Regulated by Chemically Modified Tetracycline-8 in Murine Osteoblasts Cellsc Cells" Annual Session of the AADR (2001)
  • "The Effects of Titanium-Immobilized bioactive Peptides on Osteoblast Differentiation" Osseointegration Academy Meeting (2001)
  • "Chemically Modified Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" 78th Annual Session of the IADR/29th (2000)
  • "Gene regulation by chemically Modifed Tetracylines in Murine Osteoblasts" Gordon Research Conference (1999)
  • "Non-Antimicrobial and Antimicrobial Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" New York Academy of Sciences Meeting (1998)
  • "OP-1 Induction of the Inositol Trisphosphate Receptor in Human Osteosarcoma Cells" 75th Annual Session of the AADR/25th (1997)
  • "Inositol Trisphosphate Receptor Subtype Analysis in Human Osteosarcoma Cells" 24th Session of ther AADR (1995)
  • "IgG Antibodies to A.Actinomycetemconitans 16.6 Kda OMP In Juvenile Periodontitis" 72nd Annual Session of the IADR/23th (1994)
  • "Selective Expression of Inositol Trisphosphate Rectptor Gene In Human Osteosarcoma Cells" 22nd Annual Session of the AADR (1993)
See all (3 more)
Service Activities:
  • School of Dental Medicine ByLaws Committee (2000)
  • School of Dental Medicine Curriculum Committee (2000)
  • School of Dental Medicine Student Research and Honors Committee (2000)

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
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Contact Information

University of Buffalo School of Dental Medicine 3435 Main Street 250 Squire Hall
304A Foster Hall
Buffalo, NY 14214
Phone: (716)829-3845
Email: klkirk@buffalo.edu


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