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Faculty Profile - Jacobs School of Medicine and Biomedical Sciences - University at Buffalo
University at Buffalo - The State University of New York
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Charles                        Berenson

Charles S. Berenson MD

Department of Medicine

Associate Professor and Residency Program Director, Infectious Diseases

Specialty/Research Focus

Immunology; Infectious Disease

Professional Summary:

My patient care and teaching responsibilities are centered at the Veterans Administration hospital where I care for hospitalized patients and maintain an active outpatient clinic. I enjoy teaching medical students and residents in both lecture and small group settings. In addition, my laboratory is open to interested undergraduate, graduate and medical students and residents seeking to gain a research experience.

Research interests of my laboratory focus on two key areas of the function of specialized immune cells called macrophages. Our first area of interest concentrates on the immunologic roles of mammalian macrophage gangliosides. Gangliosides are unique molecules that hold diverse regulatory roles as receptors and as mediators of cell differentiation in cells of most species. Our studies encompass ganglioside regulation of macrophage inflammatory responses, ganglioside-associated alterations of the architecture of macrophage cell membranes in HIV-infected individuals, and the function of macrophage gangliosides as receptors for bacterial pathogens and toxins. This work will lead to a better understanding of mechanisms of macrophage activation, to permit manipulation of host immune responses.

Our second area of interest centers on the regulation of inflammatory responses of human alveolar macrophages by respiratory bacterial pathogens and bacterial antigens that contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies encompass defining the repertoire of inflammatory mediators of human alveolar and blood-derived macrophages regulated by bacterial pathogens and characterizing bacteria-regulated immunologic properties of macrophages, in patients with COPD. These investigations into fundamental mechanisms of dysfunctional immune responses of macrophages underlying the progression of COPD are providing the basis for designing novel and more effective therapies.

Education and Training:
  • Fellowship, Yale University School of Medicine (1987)
  • Residency, University of Michigan Medical School (1983)
  • MD, University at Buffalo (1980)
  • Residency Program Director, Infectious Diseases, Medicine, University at Buffalo
Awards and Honors:
  • Louis A. and Ruth Siegel Award for Excellence in Teaching (2015)
  • Clinical Teaching Excellence Award (2011)
  • "White Coat" Award for Teaching Excellence (2002)
  • UB Department of Medicine Research Award (2001)
  • "White Coat" Award for Teaching Excellence (1997)
  • Clinical Teaching Excellence Award (1992)

Research Expertise:
  • Haemophilus influenzae pathogenesis
  • Immunoregulatory roles of macrophage ganglioside
  • Role of alveolar macrophages in the pathogenesis of respiratory tract infections
Grants and Sponsored Research:
  • September 2005–August 2010
    Innate immunity and Exacerbations of COPD.
    National Heart, Lung & Blood Institute
    Role: Co-Principal Investigator
  • Enhancing Nrf2 by Sulforaphane Treatment COPD as a Novel Interventional Strategy
    Role: Co-Investigator
  • Enhancing Nrf2 by Sulforaphane Treatment in9/10- COPD as a Novel Interventional Strategy- Ancillary study
    Role: Co-Investigator
  • Roflumilast modulation of macrophage function in exacerbation-prone COPD
    Forest Laboratories
    Role: Co-Investigator

Journal Articles:
See all (7 more)
Books and Book Chapters:
  • Berenson CS. Bacterial Growth and Metabolism. Microbiology and Immunology. Thacore HR, ed. Pearson Custom Publishing, Boston. 2008.

Professional Memberships:
  • American College of Physicians
  • Infectious Diseases Society of America
  • American Association of Immunologists
  • American Society for Microbiology
  • American College of Podopediatrics

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

VA Western New York Healthcare System
Research (151)
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-6529
Fax: (716) 862-6526

Patient Care

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