University at Buffalo - The State University of New York
Skip to Content
Effect of photodynamic therapy on revascularization of fasciocutaneous flaps. - PubMed - NCBI
Format

Send to

Choose Destination
See comment in PubMed Commons below
Laryngoscope. 2000 Jun;110(6):942-5.

Effect of photodynamic therapy on revascularization of fasciocutaneous flaps.

Author information

1
Department of Otolaryngology--Head and Neck Surgery, University of Pennsylvania, Philadelphia 19104-4283, USA.

Abstract

OBJECTIVE:

Photodynamic therapy (PDT) may be used as an adjuvant intraoperative treatment to improve locoregional control. PDT has been shown both to delay wound healing and to have a deleterious effect on flap survival after a primary ischemic insult. This delay in wound healing may make the flap dependent on its pedicled blood supply for a prolonged period. Long-term flap loss may be experienced. The effect of PDT on flap revascularization, with subsequent dependence on its vascular pedicle, is evaluated.

STUDY DESIGN:

Randomized controlled trial using a rodent model.

METHODS:

A rat fasciocutaneous flap was used. Study groups were as follows: group I received no treatment; group II received treatment with 630-nm light; groups IH and IV were given Photofrin (in group III, loupes without a fiberoptic light source were used for flap elevation, and in group IV, light source was employed); and group V was given Photofrin and 630-nm light. Primary ischemic times of 2 or 4 hours were used. Vascular pedicles were ligated on postoperative day (POD) 5, 6, or 7, and percentage of flap survival was evaluated 7 days later.

RESULTS:

With 2 hours of ischemia, revascularization was decreased in the PDT group on POD 6 (P < .05) and on day 7 (P < .005) when compared with the other groups. With 4 hours of ischemia, revascularization was decreased in the PDT group on PODs 5 (P < .001), 6 (P < .01), and 7 (P < .005).

CONCLUSION:

Intraoperative PDT decreases revascularization of a rat fasciocutaneous flap.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center