User profiles for author:Sekar author:Kathiresan

Sekar Kathiresan

Associate Professor of Medicine, Harvard Medical School
Verified email at
Cited by 44643

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

…, PIW de Bakker, H Chen, JJ Roix, S Kathiresan… - …, 2007 -
Abstract New strategies for prevention and treatment of type 2 diabetes (T2D) require
improved insight into disease etiology. We analyzed 386,731 common single-nucleotide
polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 -
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations
between body mass index and~ 2.8 million SNPs in up to 123,865 individuals with targeted

[HTML][HTML] Analysis of protein-coding genetic variation in 60,706 humans

…, G Getz, SJ Glatt, CM Hultman, S Kathiresan… - Nature, 2016 -
Summary Large-scale reference data sets of human genetic variation are critical for the
medical and functional interpretation of DNA sequence changes. We describe the
aggregation and analysis of high-quality exome (protein-coding region) sequence data for

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

…, L Peltonen, SM Schwartz, D Altshuler, S Kathiresan - The Lancet, 2012 - Elsevier
BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes
are randomly assigned at meiosis, are independent of non-genetic confounding, and are

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

S Kathiresan, O Melander, C Guiducci, A Surti… - Nature …, 2008 -
Abstract Blood concentrations of lipoproteins and lipids are heritable 1 risk factors for
cardiovascular disease 2, 3. Using genome-wide association data from three studies (n=
8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 -
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of
European descent followed by genotyping of top association signals in 56,682 additional

Common variants at 30 loci contribute to polygenic dyslipidemia

S Kathiresan, CJ Willer, GM Peloso, S Demissie… - Nature …, 2009 -
Abstract Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the
polygenic basis of these traits, we conducted genome-wide association screens in 19,840

Genome-wide association study identifies eight loci associated with blood pressure

…, E Org, A Pfeufer, HE Wichmann, S Kathiresan… - Nature …, 2009 -
Abstract Elevated blood pressure is a common, heritable cause of cardiovascular disease
worldwide. To date, identification of common genetic variants influencing blood pressure
has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association

[HTML][HTML] Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

AP Morris, BF Voight, TM Teslovich, T Ferreira… - Nature …, 2012 -
Abstract To extend understanding of the genetic architecture and molecular basis of type 2
diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip
involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

S Kathiresan, BF Voight, S Purcell, K Musunuru… - Nature …, 2009 -
Abstract We conducted a genome-wide association study testing single nucleotide
polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset
myocardial infarction in 2,967 cases and 3,075 controls. We carried out replication in an