Expression pattern and prognostic values of ELF5 and SNAIL2 in breast tumors
(a) Box plots showing ELF5 expression in laser capture microdissection samples of invasive ductal and lobular carcinomas as compared to normal ductal and lobular cells from matched mammary glands46. (b) Box plots showing ELF5 expression in laser capture microdissection samples of hyperplastic enlarged lobular units (HELU) as compared to normal terminal duct lobular units (TDLU)47. (c) Scatter plot showing negative correlation between SNAI2 and ELF5 expression in ER- patients in the NKI295 clinical dataset. Pearsons’ coefficient tests were performed to assess statistical significance. (d) IHC analysis showing ELF5 expression in luminal cells and SNAIL2 expression only in some basal cells in normal breast tissue (left panel). In human breast tumors, ELF5 and SNAIL2 show inverse correlation in expression (middle and right panels). Size bar = 20 μm. (e) Kaplan-Meier plots of distant metastasis-free survival of patients, stratified by expression of Elf5 or SNAI2. Data obtained from the KM plotter database49. p value calculated by log rank test. (f) Kaplan-Meier plots of distant metastasis-free survival of ER- patients stratified by Elf5 expression in the NKI295 clinical dataset. p value calculated by log rank test.