[HTML][HTML] Origins and functional impact of copy number variation in the human genome

…, D Pinto, R Redon, L Feuk, O Gokcumen, Y Zhang… - Nature, 2010 - ncbi.nlm.nih.gov
Abstract Structural variations of DNA greater than 1 kilobase in size account for most bases
that vary among human genomes, but are still relatively under-ascertained. Here we use
tiling oligonucleotide microarrays, comprising 42 million probes, to generate a

[HTML][HTML] Mapping copy number variation by population scale genome sequencing

…, AE Urban, JA Walker, J Wu, Y Zhang, ZD Zhang… - Nature, 2011 - ncbi.nlm.nih.gov
Summary Genomic structural variants (SVs) are abundant in humans, differing from other
variation classes in extent, origin, and functional impact. Despite progress in SV
characterization, the nucleotide resolution architecture of most SVs remains unknown. We

[HTML][HTML] Sequence and analysis of rice chromosome 4

…, Y Tang, Q Weng, L Zhang, Y Lu, J Mu, Y Lu, LS Zhang… - 2002 - arch.neicon.ru
Rice is the principal food for over half of the population of the world. With its genome size of
430 megabase pairs (Mb), the cultivated rice species Oryza sativa is a model plant for
genome research. Here we report the sequence analysis of chromosome 4 of O. sativa, one

[HTML][HTML] Variation in genome-wide mutation rates within and between human families

…, JEM Keebler, MA DePristo, SJ Lindsay, Y Zhang… - Nature …, 2011 - ncbi.nlm.nih.gov
Abstract JBS Haldane proposed in 1947 that the male germline may be more mutagenic
than the female 1. Diverse studies have supported Haldane's contention of a higher average
mutation rate in the male germline in a variety of mammals, including humans (eg 2, 3). Here

Demographic history and rare allele sharing among human populations

…, J Wang, W Wang, H Yang, X Zhang… - Proceedings of the …, 2011 - National Acad Sciences
Abstract High-throughput sequencing technology enables population-level surveys of
human genomic variation. Here, we examine the joint allele frequency distributions across
continental human populations and present an approach for combining complementary

Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells

AD Schecter, BJ Rollins, YJ Zhang, IF Charo… - Journal of Biological …, 1997 - ASBMB
Abstract Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine thought to play a
major role in recruiting monocytes to the atherosclerotic plaque. Tissue factor (TF), the
initiator of coagulation, is found in the atherosclerotic plaque, macrophages, and human

Processing and activation of pro-interleukin-16 by caspase-3

Y Zhang, DM Center, MH David, WW Cruikshank… - Journal of Biological …, 1998 - ASBMB
Abstract Interleukin-16, a proinflammatory cytokine produced in CD8+ lymphocytes, is
synthesized as a precursor protein (pro-IL-16). It is postulated that the C-terminal region of
pro-IL-16 is cleaved, releasing bioactive IL-16. To characterize IL-16 cleavage, we

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome

…, RA Clark, S Sokolova, ML Leibowitz, Y Zhang… - Genome …, 2010 - genome.cshlp.org
Abstract Structural variation (SV) is a rich source of genetic diversity in mammals, but due to
the challenges associated with mapping SV in complex genomes, basic questions regarding
their genomic distribution and mechanistic origins remain unanswered. We have developed

A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer.

Y Zhang, BJ Rollins - Molecular and cellular biology, 1995 - Am Soc Microbiol
ABSTRACT Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine
family of proinflammatory cytokines, all of which share a high degree of amino acid
sequence similarity. Aberrant expression of chemokines occurs in a variety of diseases that

[HTML][HTML] Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1α in hepatocellular carcinoma

L Zhang, G Huang, X Li, Y Zhang… - BMC …, 2013 - bmccancer.biomedcentral.com
Background High invasion and metastasis are the primary factors causing poor prognosis of
patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms
underlying these biological behaviors have not been completely elucidated. In this study, we