University at Buffalo - The State University of New York
Skip to Content
Molecular concepts in the pathogenesis of ameloblastoma: implications for therapeutics. - PubMed - NCBI
Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Mol Pathol. 2014 Dec;97(3):345-53. doi: 10.1016/j.yexmp.2014.09.001. Epub 2014 Sep 4.

Molecular concepts in the pathogenesis of ameloblastoma: implications for therapeutics.

Author information

1
Department of Oral and Maxillofacial Medicine and Diagnostic Science, Case Western Reserve University School of Dental Medicine, Cleveland, OH 44106, USA. Electronic address: txj113@case.edu.
2
Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA; Oral Diagnostic Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA. Electronic address: jkramer@buffalo.edu.

Abstract

Ameloblastoma is a benign odontogenic neoplasm that may exhibit aggressive biological behavior as evidenced by its rapid growth and significance recurrence rates following initial surgical resection. Currently, the only therapy for ameloblastoma is surgical, and adjunctive treatment modalities are needed to mitigate tumor growth and to reduce the need for extensive and disfiguring surgeries. Many studies have identified markers expressed by ameloblastoma and these lend insight to our understanding of tumor progression. This review provides a summary of the specific molecular pathways implicated in tumor pathogenesis, including those involved in bone remodeling, apoptosis, cell signaling, and tumor suppression. Based on these data, we identify several prognostic or therapeutic markers that have been used successfully in the treatment of other neoplastic processes that may also have diagnostic and prognostic utility for ameloblastoma. Thus, it is important to determine which markers hold the greatest promise for clinical management of this benign neoplasm in order to improve treatment options, particularly in patients with aggressive forms of ameloblastoma.

KEYWORDS:

Ameloblastoma; Ameloblastoma prognosis; Ameloblastoma therapy; Odontogenic neoplasm

PMID:
25194300
DOI:
10.1016/j.yexmp.2014.09.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center