University at Buffalo - The State University of New York
Skip to Content
Streptococcus mutans out-competes Streptococcus gordonii in vivo. - PubMed - NCBI
Format

Send to

Choose Destination
See comment in PubMed Commons below
J Dent Res. 2012 May;91(5):513-9. doi: 10.1177/0022034512442894. Epub 2012 Mar 19.

Streptococcus mutans out-competes Streptococcus gordonii in vivo.

Author information

1
Schools of Dental Medicine and Medicine, University of Connecticut Health Center, Farmington, CT 06030-1605, USA. tanzer@nso.uchc.edu

Abstract

Streptococcus gordonii and Streptococcus mutans avidly colonize teeth. S. gordonii glucosyltransferase (GtfG) and amylase-binding proteins (AbpA/AbpB), and S. mutans glucosyltransferase (GtfB), affect their respective oral colonization abilities. We investigated their interrelationships and caries association in a rat model of human caries, examining the sequence of colonization and non- vs. high-sucrose diets, the latter being associated with aggressive decay in humans and rats. Virulence-characterized wild-types of both species and well-defined mutants of S. gordonii with interrupted abpA and gtfG genes were studied. While both S. gordonii and S. mutans were abundant colonizers of rat's teeth in the presence of either diet, if inoculated singly, S. mutans always out-competed S. gordonii on the teeth, independent of diet, strain of S. mutans, simultaneous or sequential inoculation, or presence/absence of mutations of S. gordonii's abpA and gtfG genes known to negatively or positively affect its colonization and to interact in vitro with S. mutans GtfB. S. mutans out-competed S. gordonii in in vivo plaque biofilm. Caries induction reflected S. mutans or S. gordonii colonization abundance: the former highly cariogenic, the latter not. S. gordonii does not appear to be a good candidate for replacement therapy. These results are consistent with human data.

PMID:
22431892
PMCID:
PMC3327732
DOI:
10.1177/0022034512442894
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center