University at Buffalo - The State University of New York
Skip to Content
Salivary biomarkers associated with alveolar bone loss. - PubMed - NCBI

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2007 Mar;1098:496-7.

Salivary biomarkers associated with alveolar bone loss.

Author information

Departments of Oral Biology, School of Dental Medicine, State University at Buffalo, Buffalo, NY 14214, USA.


A longitudinal case-control study was performed to measure the association of salivary biomarkers with alveolar bone loss from a sub-sample of 1,256 post-menopausal women enrolled in the Buffalo Women's Health Initiative. From this cohort, 40 subjects with significant alveolar bone loss over a 5-year period were compared to 40 age-matched control subjects having no alveolar bone loss. Several biomarkers were quantitated in saliva collected at baseline by immunoassay. A positive association was noted between alveolar bone loss and salivary concentrations of hepatocyte growth factor, and interleukin-1 beta, while a negative association was noted for alveolar bone loss and salivary osteonectin. This study provides preliminary evidence that several salivary biomarkers measured at baseline may serve to predict future alveolar bone loss.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center