[HTML][HTML] Host genetic variation impacts microbiome composition across human body sites

R Blekhman, JK Goodrich… - Genome …, 2015 - genomebiology.biomedcentral.com
Background The composition of bacteria in and on the human body varies widely across
human individuals, and has been associated with multiple health conditions. While microbial
communities are influenced by environmental factors, some degree of genetic influence of

[HTML][HTML] Genetic determinants of the gut microbiome in UK twins

JK Goodrich, ER Davenport, M Beaumont… - Cell host & …, 2016 - Elsevier
Summary Studies in mice and humans have revealed intriguing associations between host
genetics and the microbiome. Here we report a 16S rRNA-based analysis of the gut
microbiome in 1,126 twin pairs, a subset of which was previously reported. Tripling the

[HTML][HTML] Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross …

LJ Leamy, SA Kelly, J Nietfeldt… - Genome …, 2014 - genomebiology.biomedcentral.com
Background Individuality in the species composition of the vertebrate gut microbiota is
driven by a combination of host and environmental factors that have largely been studied
independently. We studied the convergence of these factors in a G 10 mouse population

[HTML][HTML] Genome-wide association studies of the human gut microbiota

ER Davenport, DA Cusanovich, K Michelini… - PLoS …, 2015 - journals.plos.org
Abstract The bacterial composition of the human fecal microbiome is influenced by many
lifestyle factors, notably diet. It is less clear, however, what role host genetics plays in
dictating the composition of bacteria living in the gut. In this study, we examined the

[HTML][HTML] Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

AM McKnite, ME Perez-Munoz, L Lu, EG Williams… - PloS one, 2012 - journals.plos.org
Abstract The gastrointestinal tract harbors a complex and diverse microbiota that has an
important role in host metabolism. Microbial diversity is influenced by a combination of
environmental and host genetic factors and is associated with several polygenic diseases. In

Genetic and environmental control of host-gut microbiota interactions

E Org, BW Parks, JWJ Joo, B Emert… - Genome …, 2015 - genome.cshlp.org
Abstract Genetics provides a potentially powerful approach to dissect host-gut microbiota
interactions. Toward this end, we profiled gut microbiota using 16s rRNA gene sequencing
in a panel of 110 diverse inbred strains of mice. This panel has previously been studied for a

[HTML][HTML] Human genetics shape the gut microbiome

JK Goodrich, JL Waters, AC Poole, JL Sutter, O Koren… - Cell, 2014 - Elsevier
Summary Host genetics and the gut microbiome can both influence metabolic phenotypes.
However, whether host genetic variation shapes the gut microbiome and interacts with it to
affect host phenotype is unclear. Here, we compared microbiotas across> 1,000 fecal

The effect of host genetics on the gut microbiome

MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic… - Nature …, 2016 - nature.com
Supplementary Table 3) and a total of 33 loci were associated with functional units, with 21
loci associated with MetaCyc pathways and 12 loci associated with GO2000 groups (Fig. 2,
Supplementary Figs. 2 and 3, and Supplementary Table 3), at P< 5× 10− 8 (false discovery

Cross-species comparisons of host genetic associations with the microbiome

JK Goodrich, ER Davenport, JL Waters, AG Clark… - …, 2016 - science.sciencemag.org
Abstract Recent studies in human populations and mouse models reveal notable
congruences in gut microbial taxa whose abundances are partly regulated by host
genotype. Host genes associating with these taxa are related to diet sensing, metabolism,

[HTML][HTML] Complex host genetics influence the microbiome in inflammatory bowel disease

D Knights, MS Silverberg… - Genome …, 2014 - genomemedicine.biomedcentral …
Background Human genetics and host-associated microbial communities have been
associated independently with a wide range of chronic diseases. One of the strongest
associations in each case is inflammatory bowel disease (IBD), but disease risk cannot be