Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
RNA-Seq reveals distinct expression patterns for TAp63 and ∆Np63. a Cartoon depicting ∆NP63 (α, β, γ) and TAp63α gene structure. TA β and γ (not shown) undergo similar alternative splicing to ∆NP63 (β, γ). TA, transactivation; Oligo, oligomerization; SAM, sterile alpha motif; TID, transactivation-inhibitory domain; UTR, untranslated region. b Snapshot from UCSC genome browser showing distribution of the aligned RNA-Seq reads at the TP63 locus in representative epithelial cell-lines (Head and neck squamous cell carcinoma (SCC) cell-lines: SCC4 and SCC15) and Non-Hodgkin lymphomas (Burkitt lymphoma cell-lines: Raji and BL2). c Heatmap depicting the expression of p63 isoforms (average across replicates) in FPKM (fragments per kilobase of transcript per million) across representative p63 expressing cell-lines