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PubMed Central, Figure 2: Cell Death Differ. 2016 Jun; 23(6): 1073–1085. Published online 2016 Jan 15. doi:  10.1038/cdd.2015.162
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Global transcription changes precede immune-mediated inflammatory skin lesions of ΔNp63 transgenic mice. (a) Canonical signaling pathways significantly enriched among documented annotations for the 1901 significantly differentially expressed genes (DEGs) in transgenic epidermis. (b) Global gene expression behavior of significant and near-significant. (fold-change >4) DEGs-populating key pathways is highlighted (orange) and underlined in panel (a). (c) Heatmap depicting the relative expression behavior of selected DEGs involved in dermatitis (D), keratinocyte differentiation (K) and inflammation (I) using IPA annotations (shown in blue). WT, wild-type; BG, bi-transgenic

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